Cytoglobin: A novel potential gene medicine for fibrosis and cancer therapy

Current Gene Therapy

Volumn 8, Issue 4, 2008, Pages 287-294

  Lv, Yinghui ^a,b   Wang, Qizhao ^a,b   Diao, Yong ^a,b   Xu, Ruian ^a,b  

^a HUAQIAO UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Gene therapy; Hexacoordination; Hypermethylated; Hypoxia; Oxidative stress; Stellate cell; Tumor suppressor; Up regulation

Indexed keywords

CYTOGLOBIN; PARVOVIRUS VECTOR;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BINDING AFFINITY; CANCER GENE THERAPY; CELL BASED GENE THERAPY; CELL PROTECTION; DIABETES MELLITUS; DISEASE COURSE; DRUG STRUCTURE; FIBROGENESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE OVEREXPRESSION; GENE STRUCTURE; HEAD AND NECK CANCER; HUMAN; ISCHEMIA; LIVER FIBROSIS; LIVER INJURY; LUNG NON SMALL CELL CANCER; NONHUMAN; OXIDATIVE STRESS; OXYGEN AFFINITY; PHYLOGENY; PROTEIN ANALYSIS; PROTEIN FUNCTION; REPERFUSION INJURY; REVIEW; STELLATE CELL; TUMOR SUPPRESSOR GENE; UPREGULATION;

ANIMALS; DIABETES MELLITUS; FIBROSIS; GENE THERAPY; GENETIC VECTORS; GLOBINS; HUMANS; NEOPLASMS;

RATTUS;

EID: 54749127408     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652308785160656     Document Type: Review

References (69)

1. Roesner A, Fuchs C, Hankeln T, Burmester T. A globin gene of ancient evolutionary origin in lower vertebrates: evidence for two distinct globin families in animals. Mol Biol Evol 2005; 22: 12-20.
2. Fuchs C, Burmester T, Hankeln T. The amphibian globig gene repertoire as revealed by the Xenopus genome. Cytogenet Genome Res 2006; 112: 296-6.
3. Dickerson RE, Geis I. Hemoglobin: structure, function, evolution, and pathology, Benjamin/Cummings, Menlo Park, CA 1983.
4. Hankeln T, Ebner B, Fuchs C, et al. Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem 2005; 99: 110-19.
5. 2-binding kinetics of a recombinant protein synthesized in Escherichia coli. Plant Physiol 1997; 115: 1259-66.
6. Kawada N, Kristensen DB, Asahina K, et al. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem 2001; 276: 25318-323.
7. Trent III JT, Hargrove MS. A ubiquitously expressed human hexacoordinate hemoglobin. J Biol Chem 2002; 277: 19538-19545.
8. Hvitved AN, Trent III JT, Premer SA, Hargrove MS. Ligand binding and hexacoordination in synechocystis hemoglobin. J Biol Chem 2001; 276: 34714-721.
9. Hunt, PW, Watts RA, Trevaskis B, et al. Expression and evolution of functionally distinct haemoglobin genes in plants, Plant Mol Biol 2001, 47: 677-92.
10. Burmester T, Ebner E, Weich B, Hankeln T. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Mol Biol Evol 2002; 19: 416-21.
11. Burmester T, Weich B, Reinhard S, Hankeln T. A vertebrate globin expressed in the brain. Nature 2000; 407: 520-23.
12. Kawada N. Molecular mechanism of stellate cell activation and therapeutic strategy for liver fibrosis. Comp Hepatol 2004; 3: S3.
13. Schmidt M, Gerlach F, Avivi A, et al. Cytoglobin is a respiratory protein in connective tissue and, neurons, which is up-regulated by hypoxia. J Biol Chem 2004; 279:8063-69.
14. Miyata Y, Ashida S, Nakamura T, et al. Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo. Biochem Biophys Res Commun 2003; 302: 892-97.
15. Muddu AK, Guha IN, Elsharkawy AM, Mann DA. Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic. Int J Biochem Cell Biol 2007; 39: 695-14.
16. de Sanctis D, Dewilde S, Pesce A, et al. Crystal structure of cytoglobin the fourth globin type discovered in man displays heme hexa-coordination. J Mol Biol 2004; 336:917-27.
17. Pesce A, Bolognesi M, Bocedi A, et al. Neuroglobin and cytoglobin: Fresh blood for the vertebrate globin family. EMBO Rep 2002; 3:1146-51.
18. Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, Shiro Y. Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry 2003; 42: 5133-5142.
19. Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y. Structural basis of human cytoglobin for ligand binding. J Mol Biol 2004; 339: 873-85.
20. Vallone B, Nienhaus K, Brunori M, Nienhaus GU. The structure of murine neuroglobin: novel pathways for ligand migration and binding. Proteins 2004; 56: 85-92.
21. Sawai H, Makino M, Mizutani Y, et al. Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry 2005; 44:13257-265.
22. Makirxo M, Sugimoto H, Sawai H, Kawada N, Yoshizato K, Shiro Y. High-resolution structure of human cytoglobin: identification of extra N- and C-termini and a new dimerization mode. Acta Cryst 2006, 62:671-77.
23. Hamdane D, Kiger L, Dewilde S, et al. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J Biol Chem 2003; 278: 51713-721.
24. Burmester T, Haberkamp M, Mitz S, et al. Neuroglobin and cytoglobin genes, proteins and evolution. IUBMB Life 2004; 56: 703-707.
25. Asahina K, Kawada N, Kristensen DB, et al. Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim Biophys Acta 2002; 1577: 471-75.
26. McRonald FE, Liloglou T, Xinarianos G, et al. Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. Hum Mol Genet 2006; 15: 1271-77.
27. Fuchs C, Luckhardt A, Gerlach F, Burmester T, Hankeln T. Duplicated cytoglobin genes in teleost fishes. Biochem Biophys Res Commun 2005; 337: 216-23.
28. Kugelstadt D, Haberkamp M, Hankeln T, Burmester T. Neuroglobin, cytoglobin, and a novel, eye-specific globin from chicken. Biochem Biophys Res Commun 2004; 325: 719-25.
29. McLysaght A, Hokamp K, Wolfe KH. Extensive genomic duplication during early chordate evolution. Nat Genet 2002; 31: 200-204.
30. Wystub S, Ebner B, Fuchs C, Weich B, Burmester T. Hankeln T. Interspecies comparison of neuroglobin, cytoglobin and myoglobin: sequence evolution and candidate regulatory elements. Cytogenet Genome Res 2004; 105: 65-78.
31. Ostojic J, Sakaguchi DS, de Lathouder Y, Hargrove MS, Trent III JT, Kwon YH et al. Neuroglobin and cytoglobin: oxygen-binding. proteins in retinal neurons. Invest Ophthalmol Vis Sci 2006; 47: 1016-23.
32. Schmidt M, Giessl A, Laufs T, Hankeln T, Wolfrum U, Burmester T. How does the eye breathe? Evidence for neuroglobin mediated oxygen supply in the mammalian retina. I Biol Chem 2003; 278: 1932-35.
33. Schmidt M, Laufs T, Reussc S, Hankein T. Burmester T. Divergent distribution of cytoglobin and neuroglobin in the murine eye. Neurosc Lett 2005, 374: 207-11.
34. Hankeln T, Wystub S, Laufs T, Schmidt M, Gerlach F, Saaler-Reinhardt S et al. The cellular and subcellular localization of neuroglobin and cytoglobin: a clue to their function? IUBMB Life 2004; 56:671-79.
35. Xi Y, Obara M, Ishida Y, Ikeda S, Yoshizato K. Gene expression and tissue distribution of cytoglobin and myoglobin in the Amphibia and Reptilia: possible compensation of myoglobin with cytoglobin in skeletal muscle cells of anurans that lack the myoglobin gene. Gene 2007; 398: 94-102.
36. Nakatani K, Okuyama H, Shimahara Y, et al. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Lab Invest 2004 84: 91-101.
37. Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, Moens L. EA Globin in the Nucleus! I Biol Chem 2003; 278. 30417-420.
38. Hodges NJ, Innocent N, Dhanda S, Graham M. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. Mutagenesis 2008; 23(4): 293-8.
39. Eng FJ, Friedman SL. Transcriptional regulation in hepatic stellate cells. Semin Liver Dis 2001; 21:385-95.
40. Rippe RA, Schrum LW, Stefanovic B, Solis-Herruzo JA, Brenner DA. NF-kappaB inhibits expressioh of the alphal(1) collagen gene. DNA Cell Biol 1999; 18: 751-61.
41. Chen A, Davis B. The DNA binding protein BTEB; mediates acetaldehyde-induced, jun N-terminal kinase-dependent alpha (1) collagen gene expression in rat hepatic stellate cells. Mol Cell Biol 2000; 20:2818-826.
42. Guo X, Philipsen S, Tan-Un KC. Characterization of human cytoglobin gene promoter region. Biochim Biophys Acta 2006; 1759: 208-15.
43. Nakamura Y, Esnault S, Maeda T, Kelly EA, Matter IS, Jarjour NN. Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts. J Immunol 2004, 172: 1945-52.
44. Hirota K, Semenza GL. Regulation of angiogenesis by hypoxiain-ducible factor 1. Crit Rev Oncol Hematol 2006; 59: 15-26.
45. Fordel E, Geuens E, Dewilde S, et al. Hypoxia/ischemia and the regulation of neuroglobin and cytoglobin expression. Biochem, Biophys Res Commun 2004; 319:342-48.
46. Guo X, Philipsen S, Tan-Un KC. Study of the hypoxia-dependent regulation of human CYGB gene. Biochem Biophys Res Commun 2007; 364: 145-50.
47. Fordel E, Geuens E, Dewilde S, de Coen W, Moens L. Hypoxia/ischemia and the regulation of neuroglobin and cytoglobin expression. IUBMB Life 2004; 56: 681-87.
48. Mammen PPA, Shelton JM, Ye Q, et al. Cytoglobin is a stress-responsive hemoprotein expressed in the developing and adult brain. J Histochem Cytochem 2006; 54: 1349-61.
49. Fordel E, Thijs L, Moens L, Dewilde S. Neuroglobin and cytoglobin expression in mice: evidence for a correlation with reactive oxygen species scavenging. FEBS 12007; 274: 1312-17.
50. Li RC, Lee SK, Pouranfar F, et al. Hyproxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. Brain Res 2006; 1096: 173-79.
51. Kida Y, Asahina K, Inoue K, et al. Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells. Arch Histol Cytol 2007; 70:95-106.
52. Herold S, Fago A, Weber RE, Dewilde S, Moens L. Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stress. J Biol Chem 2004; 279: 22841-847.
53. Fordel E, Thijs L, Martinet W, et al. Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. Neurosci Lett 2006; 410: 146-51.
54. Fordel E, Thijs L, Martinet W, Schrijvers D, Moens L, Dewilde S. Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions. Gene 2007; 398: 114-22.
55. Li D, Chen XQ, Li WJ, Yang YH, Wang JZ, Yu AC. Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress. Neurochem Res 2007; 32: 1375-80.
56. Xu R, Harrison PM, Chen M, et al. Cytoglobin overexpression protects against damage-induced fibrosis. Mol Ther 2006; 13: 1093-100.
57. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 2006; 130: 1886-900.
58. Seki E, De Minicis S, Osterreicher CH, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007; 13: 1324-332.
59. Xinarianos G, McRonald FE, Risk JM, et al. Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. Hum Mol Genet 2006; 15:2038-044.
60. Thurlow JK, Hunter KD, Flemming J, et al. Expression profile of HNSCC in relation to immortality and invasion. NCRI Conference Birmingham 2005.
61. Shaw RJ, Liloglou T, Rogers SN, et al. Promoter methylation of P16, RARb, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Brit J Cancer 2006; 94: 561-68.
62. Shaw RJ, Hall GL, Woolgar JA, et al. Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 2007; 45:617-22.
63. Risk JM, Evans KE, Jones J, et al. Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus. Oncogene 2002; 21: 6395-402.
64. Presneau N, Dewar K, Forgetta V, Provencher D, Mes-Masson AM, Tonin PN. Loss of heterozygosity and transcriptome analyses of a 1.2 Mb candidate ovarian cancer tumor suppressor locus region at 17q25.1-q25.2. Mol Carcinog 2005; 43: 141-54.
65. Stagner JI, Parthasarathy SN, Wyler K, Parthasarathy RN. Protection from ischemic cell death by the induction of cytoglobin. Transplant Proc 2005; 37: 3452-453.
66. Pulitanò C, Aldrighetti L. The protective role of steroids in ischemia-reperfusion injury of the liver. Curr Pharm Des 2008; 14: 496-03.
67. Ritter T, Kupiec-Weglinski JW. Gene therapy for the prevention of ischemia/reperfusion injury in organ transplantation. Curr Gene Ther 2005; 5: 101-09.
68. NTR. Science 2007; 315: 1853-856.
69. Li X, Lv Y, Xu RA. Liver fibrosis molecular therapy. In: Xu RA, Chen L, Xiao W, Eds. Molecular Gene Medicine. Peking, Peking University Press & Peking University Medical Press; pp 272-01 2008.