Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR

Science

Volumn 315, Issue 5820, 2007, Pages 1853-1856

  Passino, Melissa A ^a   Adams, Ryan A ^a   Sikorski, Shoana L ^a   Akassoglou, Katerina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN RECEPTOR; PROTEIN P75; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; SCATTER FACTOR; TNFRSF16 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

DISEASE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC DIFFERENTIATION; GROWTH; PATHOLOGY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IN VIVO STUDY; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER INJURY; LIVER REGENERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STELLATE CELL; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE COURSE; FIBROBLAST; GENETICS; LIVER; LIVER DISEASE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; FIBROBLASTS; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; LIVER; LIVER DISEASES; LIVER REGENERATION; MICE; NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 34147117966     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1137603     Document Type: Article

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30. NTR antibodies, respectively, invaluable discussions, and critical reading of the manuscript; J. Heller Brown for the constitutive active adenoviral Rho vector; J. Han and T. Nuriel for technical assistance; members of P. Insel's lab for assistance with real-time polymerase chain reaction (PCR) and αSMA immunostaining protocol; W. Naugler for primary hepatocyte culture protocols; R. Rippe for HSC culture protocols; and K. Barren for critical reading of the manuscript. Supported by NIH/ National Institute of Neurological Disorders and Stroke (NINDS) grant P30-NS047101 to the UCSD Neuroscience Microscopy Shared Facility, NIH training grant 5T32-GM07752 to MAP., and NIH/NINDS grant NS051470 to K.A.