The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators

Pharmacology Biochemistry and Behavior

Volumn 91, Issue 2, 2008, Pages 252-260

  Nogueira Neto, Francisco de Sousa ^a,b   Amorim, Renée L ^b   Brigatte, Patrícia ^a   Picolo, Gisele ^a   Ferreira Jr , Wilson A ^a   Gutierrez, Vanessa P ^a   Conceição, Isaltino Marcelo ^a   Della Casa, Maisa S ^a   Takahira, Regina K ^b   Nicoletti, José Luis M ^b   Cury, Yara ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Antinociception; Crotalus durissus terrificus venom; Crotoxin; Eicosanoids; Muscarinic receptors; Neuropathic pain

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ARACHIDONATE 5 LIPOXYGENASE; CROTOXIN; ICOSANOID; MUSCARINIC RECEPTOR; SEROTONIN RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; HYPERALGESIA; MALE; NERVE TRANSECTION; NEUROMA; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CREATINE KINASE; CROTOXIN; EICOSANOIDS; HYPERALGESIA; INDOMETHACIN; MALE; MOTOR ACTIVITY; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RECEPTORS, MUSCARINIC; SCIATIC NERVE; SEROTONIN;

CROTALUS DURISSUS TERRIFICUS; RATTUS;

EID: 54449096237     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.08.016     Document Type: Article

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