Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-azabicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 3, 2007, Pages 1294-1304

  Sullivan, Nicole R ^a   Leventhal, Liza ^a   Harrison, James ^a   Smith, Valerie A ^a   Cummons, Terri A ^a   Spangler, Taylor B ^a   Sun, Shaiu Ching ^a   Lu, Peimin ^a   Uveges, Albert J ^a   Strassle, Brian W ^a   Piesla, Michael J ^a   Ramdass, Rana ^a   Barry, Alena ^a   Schantz, Jonathan ^a   Adams, William ^a   Whiteside, Garth T ^a   Adedoyin, Adedayo ^a   Jones, Philip G ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 HEXYLSULFANYL PYRAZIN 2 YLOXY) 1 AZABICYCLO[2.2.1]HEPTANE; CARBACHOL; CELECOXIB; CYCLIC AMP; FORSKOLIN; GABAPENTIN; MORPHINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM MOBILIZATION; CHRONIC INFLAMMATION; CHRONIC PAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; IN VITRO STUDY; IN VIVO STUDY; IRRITABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NEUROPATHIC PAIN; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; RODENT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BIOLOGICAL AVAILABILITY; BRIDGED COMPOUNDS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; INFLAMMATION; INHIBITORY CONCENTRATION 50; MUSCARINIC AGONISTS; PAIN; PYRAZINES; RATS; RECEPTORS, MUSCARINIC;

EID: 34548105418     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.118604     Document Type: Article

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