δ-Opioid receptors and nitric oxide mediate the analgesic effect of Crotalus durissus terrificus snake venom

European Journal of Pharmacology

Volumn 391, Issue 1-2, 2000, Pages 55-62

  Picolo, Gisele ^a   Giorgi, Renata ^a   Cury, Yara ^a  

^a INSTITUTO BUTANTAN   (Brazil)

Author keywords

Analgesia; Crotalus durissus terrificus venom; Nitric oxide (NO); Opioid receptor

Indexed keywords

CARRAGEENAN; CYCLIC GMP; DELTA OPIATE RECEPTOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; METHYLENE BLUE; N(G) METHYLARGININE; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORBINALTORPHIMINE; SNAKE VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EDEMA; HYPERALGESIA; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, NON-NARCOTIC; ANIMALS; ARGININE; CARRAGEENAN; CROTALID VENOMS; CYCLIC GMP; EDEMA; ENZYME INHIBITORS; HYPERALGESIA; MALE; METHYLENE BLUE; MOTOR ACTIVITY; NARCOTIC ANTAGONISTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 0034629110     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00934-6     Document Type: Article

References (40)

1. Brazil V., Pestana B.R. Nova contribuição ao estudo do envenenamento ophidico. Rev. Med. S. Paulo. 12:1909;415-425.
2. Brigatte P., Bernardi M.M., Cury Y. Caracterização da tolerância ao efeito antinociceptivo do veneno de Crotalus durissus terrficus. XIII Reunião da Federação de Sociedades de Biologia Experimental, Caxambú, Brasil. 1998.
3. Broadhurst P.L. Experiments in psychogenetics. Eysench A.J. Experiments in Personality. 1960;3-71 Routledge and Kegan Paul, London.
4. Chen R., Robinson S.E. The effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice. Life Sci. 47:1990;1949-1954.
5. Dutta A.S., Chaudhuri A.K.N. Neuropharmacological studies on the venom of Vipera russeli. Ind. J. Exp. Biol. 29:1991;937-942.
6. Ferreira S.H. Prostaglandins, aspirin-like drugs and analgesia. Nature, New Biol. 240:1972;200-203.
7. Ferreira S.H. Peripheral analgesia: mechanism of the analgesic action of aspirin like drugs and opiate-antagonists. Br. J. Clin. Pharmacol. 10:1980;2375-2455.
8. Ferreira S.H. A classification of peripheral analgesics based upon their mode of action. Sandler M., Collins G.M. Migraine: Spectrum of Ideas. 1990;59-72 Oxford Univ. Press, Oxford.
9. Ferreira S.H., Duarte I.D.G., Lorenzetti B.B. Molecular basis of acetylcholine and morphine analgesia. Drugs in Inflammation. 1991;101-106 Birkhäuser, Basel.
10. Ferreira S.H., Duarte I.D.G., Lorenzetti B.B. The molecular mechanism of action of peripheral morphine analgesia: stimulation of cGMP system via nitric oxide release. Eur. J. Pharmacol. 1217:1991;225-227.
11. Ferreira S.H., Lorenzetti B.B., Devissaguet M., Lesieur D., Tsouderos Y. S14080, a peripheral analgesic by release of an endogenous circulating opioid-like substance. Br. J. Pharmacol. 114:1995;303-308.
12. Ferreira S.H., Lorenzetti B.B., Rae G.A. Is methylnalorphinium the prototype of an ideal peripheral analgesic? Eur. J. Pharmacol. 99:1984;23-29.
13. Ferreira S.H., Moncada S., Vane J.R. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br. J. Pharmacol. 49:1973;86-97.
14. Ferreira S.H., Nakamura M. Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins. 18:1979;191-200.
15. Ferreira S.H., Nakamura M. II. Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid antagonists. Prostaglandins. 18:1979;201-208.
16. Gebhart O.F., Sherman A.D., Mitchell C.L. The influence of learning on morphine analgesia and tolerance development in rats tested on the hot-plate. Psychopharmacology. 22:1971;295-305.
17. Giorgi R., Bernardi M.M., Cury Y. Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom. Toxicon. 31:1993;1257-1265.
18. Giorgi R., Bernardi M.M., Cury Y. Central and peripheral mechanisms of the analgesic effect of Crotalus durissus terrificus (Cdt) snake venom. Toxicon. 36:1998;1260.
19. Granados-Soto V., Rufino M.O., Lopes L.D.G., Ferreira S.H. Evidence for the involvement of the nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test. Eur. J. Pharmacol. 340:1997;177-180.
20. Hoffmann F., Giorgi R., Bernardi M.M., Cury Y. Sobre o efeito antinociceptivo do veneno de Crotalus durissus terrificus (VCdt): II. Estudo do desenvolvimento de abstinência. IX Reunião da Federação de Sociedades de Biologia Experimental, Caxambú, Brasil. 1994.
21. Jacob J.J.C., Ramabadran K. Enhancement of a nociceptive reaction by opioid antagonists in mice. Br. J. Pharmacol. 64:1978;91-98.
22. Kayser V., Chen Y.L., Guilbauld G. Behavioral evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenin-induced hyperalgesia rats. Brain Res. 560:1991;237-244.
23. Koob G.F., Bloom F.E. Cellular and molecular mechanisms of drug dependence. Science. 242:1988;715-723.
24. 2. Br. J. Pharmacol. 114:1995;578-583.
25. Lorenzetti B.B., Ferreira S.H. The analgesic effect of quaternary analogues of morphine and nalorphine. Braz. J. Med. Biol. Res. 15:1982;285-290.
26. Lorenzetti B.B., Ferreira S.H. Mode of analgesic action of dypirone: direct antagonism of inflammatory hyperalgesia. Eur. J. Pharmacol. 114:1985;375-381.
27. Nozaki-Taguchi N., Yamamoto T. Involvement of nitric oxide in peripheral antinociception mediated by κ and δ-opioid receptors. Anesth. Analg. 87:1998;388-393.
28. Picolo G., Giorgi R., Bernardi M.M., Cury Y. The antinociceptive effect of Crotalus durissus terrificus snake venom is mainly due to supraspinally integrated response. Toxicon. 36:1998;223-227.
29. Pu X.C., Wong P.T.H., Gopalakrishnakone P. A novel analgesic toxin (Hannalgesin) from the venom of King cobra (Ophiophagus hannah). Toxicon. 33:1995;1425-1431.
30. Randall L.O., Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther. 111:1957;209-219.
31. Sokal R.R., Rohlf F.J. Biometry. 2nd edn. 1981;859 Freeman, New York.
32. Sousa e Silva M.C.C., Gonçalves L.R.C., Mariano M. The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti-inflammatory properties. Mediators Inflammation. 5:1996;18-23.
33. Stein C., Hassan A.H.S., Przewlocki R., Gramsch C., Peter K., Herz A. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl. Acad. Sci. U.S.A. 87:1990;5935-5939.
34. Stein C., Millan M.J., Shippenberg T.S., Herz A. Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat. Neurosci. Lett. 84:1988;225-228.
35. Stein C., Millan M.J., Shippenberg T.S., Peter K., Herz A. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J. Pharmacol. Exp. Ther. 248:1989;1269-1275.
36. Tokuyama S., Inoue M., Fuchigami T., Ueda H. Lack of tolerance in peripheral opioid analgesia in mice. Life Sci. 62:1998;1677-1681.
37. Van Arman C.G., Begany A.J., Miller L.M., Press H.H. Some details of inflammations caused by yeast and carrageenan. J. Pharmacol. Exp. Ther. 150:1965;328-334.
38. Vital-Brazil O. Venenos ofídicos neurotóxicos. Ver. Ass. Med. Brasil. 26:1980;212-218.
39. Xiong Y., Wang W., Pu X., Song Y., Liu N., Mao J. The study on the mechanism to use the neurotoxin from cobra venom to substitute morphine. Gopalakrishnakone P., Tan C.K. Recent Advances in Toxinology Research. Vol. 1:1992;796-804 Venom and Toxin Research Group, National University of Singapore, Singapore.
40. Xiong Y., Wang W., Pu X., Song Y., Liu N., Mao J. The study on the using snake venoms to substitute morphine. Gopalakrishnakone P., Tan C.K. Recent Advances in Toxinology Research. Vol. 1:1992;805-815 Venom and Toxin Research Group, National University of Singapore, Singapore.