Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors

Journal of Organic Chemistry

Volumn 69, Issue 21, 2004, Pages 7058-7065

  Patel, Meena V ^a   Bell, Randy ^a   Majest, Sandra ^a   Henry, Rodger ^a   Kolasa, Teodozyj ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; ENZYMES; ORGANIC ACIDS; SYNTHESIS (CHEMICAL); X RAY CRYSTALLOGRAPHY;

BENZOIC ACID; CYCLIZATION; SELECTIVITY ANALYSIS;

DERIVATIVES;

1H PYRAZOLE 3 OL DERIVATIVE; ACETAL; BENZOXAZINE DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ENZYME INHIBITOR; PYRAZOLE DERIVATIVE; PYRAZOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CYCLIZATION; DERIVATIZATION; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; RECEPTOR AFFINITY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES;

EID: 5444264524     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo049264k     Document Type: Article

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