Solution-phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 8, 2001, Pages 1089-1092

  Selwood, David L ^a   Brummell, David G ^a   Glen, Robert C ^b   Goggin, Maria C ^a   Reynolds, Karen ^a   Tatlock, Mark A ^a   Wishart, Grant ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TRIPOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CARBOXAMIDO 1 BENZYL 3 (3 DIMETHYLAMINOPROPYLOXY) 1H PYRAZOLE DERIVATIVE; ACID; CARBONIC ACID; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; PYRAZOLE DERIVATIVE; RESIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; DRUG SYNTHESIS; ENZYME ACTIVATION; LIPOPHILICITY; NONHUMAN; RAT; THROMBOCYTE AGGREGATION INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; COLLAGEN; CYCLIC GMP; ENZYME ACTIVATORS; GUANYLATE CYCLASE; INHIBITORY CONCENTRATION 50; PLATELET AGGREGATION; PYRAZOLES; RATS;

EID: 0035938403     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00141-X     Document Type: Article

References (12)