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Volumn 91, Issue 2, 2004, Pages 501-512

Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2

Author keywords

Cell morphology; G protein coupled receptor; PIP2; Rac1; RhoA; Small G protein

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PLECKSTRIN; RAC1 PROTEIN; RECEPTOR; RHO FACTOR; THROMBIN; THROMBIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 5444236527     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02749.x     Document Type: Article
Times cited : (28)

References (64)
  • 2
    • 0031029553 scopus 로고    scopus 로고
    • Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells: A direct evaluation of selectivity in receptor-G protein coupling
    • Barr A. J., Brass L. F. and Manning D. R. (1997) Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells: a direct evaluation of selectivity in receptor-G protein coupling. J. Biol. Chem. 272, 2223-2229.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2223-2229
    • Barr, A.J.1    Brass, L.F.2    Manning, D.R.3
  • 3
    • 0037986310 scopus 로고    scopus 로고
    • Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
    • Baumeister M. A., Martinu L., Rossman K. L., Sondek J., Lemmon M. A. and Chou M. M. (2003) Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J. Biol. Chem. 278, 11 457-11 464.
    • (2003) J. Biol. Chem. , vol.278
    • Baumeister, M.A.1    Martinu, L.2    Rossman, K.L.3    Sondek, J.4    Lemmon, M.A.5    Chou, M.M.6
  • 5
    • 0036786445 scopus 로고    scopus 로고
    • Characterization of 1pa(2)(Edg4) and 1pa(1)/1pa(2)(Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to 1pa(2)
    • Contos J. J., Ishii I., Fukushima N., Kingsbury M. A. Ye X., Kawamura S., Brown J. H. and Chun J. (2002) Characterization of 1pa(2)(Edg4) and 1pa(1)/1pa(2)(Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to 1pa(2). Mol. Cell Biol. 22, 6921-6929.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 6921-6929
    • Contos, J.J.1    Ishii, I.2    Fukushima, N.3    Kingsbury, M.A.4    Ye, X.5    Kawamura, S.6    Brown, J.H.7    Chun, J.8
  • 8
    • 0030833883 scopus 로고    scopus 로고
    • High concentrations of phospha-tidylinositol-4,5-bisphosphate may promote actin filament growth by three potential mechanisms: Inhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-beta2 from barbed ends
    • DiNubile M. J. and Huang S. (1997) High concentrations of phospha-tidylinositol-4,5-bisphosphate may promote actin filament growth by three potential mechanisms: inhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-beta2 from barbed ends. Biochim. Biophys. Acta 1358, 261-278.
    • (1997) Biochim. Biophys. Acta , vol.1358 , pp. 261-278
    • DiNubile, M.J.1    Huang, S.2
  • 10
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • Fukuhara S., Murga C., Zohar M., Igishi T. and Gutkind J. S. (1999) A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274, 5868-5879.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5868-5879
    • Fukuhara, S.1    Murga, C.2    Zohar, M.3    Igishi, T.4    Gutkind, J.S.5
  • 11
    • 0035854829 scopus 로고    scopus 로고
    • Gα minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation
    • Gilchrist A., Vanhauwe J. F., Li A., Thomas T. O., Voyno-Yasenetskaya T. and Hamm H. E. (2001) Gα minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J. Biol Chem. 276, 25 672-25 679.
    • (2001) J. Biol Chem. , vol.276
    • Gilchrist, A.1    Vanhauwe, J.F.2    Li, A.3    Thomas, T.O.4    Voyno-Yasenetskaya, T.5    Hamm, H.E.6
  • 12
    • 0029943112 scopus 로고    scopus 로고
    • Regulation of vinculin binding to talin and actin by phosphatidylinositol-4-5-bisphosphate
    • Gilmore A. P. and Burridge K. (1996) Regulation of vinculin binding to talin and actin by phosphatidylinositol-4-5-bisphosphate. Nature 381, 531-535.
    • (1996) Nature , vol.381 , pp. 531-535
    • Gilmore, A.P.1    Burridge, K.2
  • 13
    • 0032548503 scopus 로고    scopus 로고
    • 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho
    • 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem. 273, 4653-4659.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4653-4659
    • Gohla, A.1    Harhammer, R.2    Schultz, G.3
  • 15
    • 0028021882 scopus 로고
    • Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
    • Harlan J. E., Hajduk P. J., Yoon H. S. and Fesik S. W. (1994) Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371, 168-170.
    • (1994) Nature , vol.371 , pp. 168-170
    • Harlan, J.E.1    Hajduk, P.J.2    Yoon, H.S.3    Fesik, S.W.4
  • 17
    • 0026334228 scopus 로고
    • F-Actin capping by cap32/34 requires heterodimeric conformation and can be inhibited with PIP2
    • Haus U., Hartmann H., Trommler P., Noegel A. A. and Schleicher M. (1991) F-Actin capping by cap32/34 requires heterodimeric conformation and can be inhibited with PIP2. Biochem. Biophys. Res. Commun. 181, 833-839.
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 833-839
    • Haus, U.1    Hartmann, H.2    Trommler, P.3    Noegel, A.A.4    Schleicher, M.5
  • 20
    • 0141890280 scopus 로고    scopus 로고
    • Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion
    • Howes A. L., Arthur J. F., Zhang T., Miyamoto S., Adams J. W., Dorn I. I. G. W., Woodcock E. A. and Brown J. H. (2003) Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J. Biol. Chem. 278, 40 343-40 351.
    • (2003) J. Biol. Chem. , vol.278
    • Howes, A.L.1    Arthur, J.F.2    Zhang, T.3    Miyamoto, S.4    Adams, J.W.5    Dorn, I.I.G.W.6    Woodcock, E.A.7    Brown, J.H.8
  • 21
    • 0028021308 scopus 로고
    • Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
    • Jalink K., van Corven E. J., Hengeveld T., Morii N., Narumiya S. and Moolenaar W. H. (1994) Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol. 126, 801-810.
    • (1994) J. Cell Biol. , vol.126 , pp. 801-810
    • Jalink, K.1    Van Corven, E.J.2    Hengeveld, T.3    Morii, N.4    Narumiya, S.5    Moolenaar, W.H.6
  • 22
    • 0034597743 scopus 로고    scopus 로고
    • Activation of RhoA by association of Galpha (13) with DbI
    • Jin S. and Exton J. H. (2000) Activation of RhoA by association of Galpha (13) with DbI. Biochem. Biophys. Res. Commun. 277, 718-721.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 718-721
    • Jin, S.1    Exton, J.H.2
  • 23
    • 0029860810 scopus 로고    scopus 로고
    • Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho
    • Katoh H., Negishi M. and Ichikawa A. (1996) Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho. J. Biol. Chem. 271, 29 780-29 784.
    • (1996) J. Biol. Chem. , vol.271
    • Katoh, H.1    Negishi, M.2    Ichikawa, A.3
  • 25
    • 0000315614 scopus 로고    scopus 로고
    • Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA
    • Kranenburg O., Poland M., Gebbink M., Oomen L. and Moolenaar W. H. (1997) Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. J. Cell Sci. 110, 2417-2427.
    • (1997) J. Cell Sci. , vol.110 , pp. 2417-2427
    • Kranenburg, O.1    Poland, M.2    Gebbink, M.3    Oomen, L.4    Moolenaar, W.H.5
  • 27
    • 1242272132 scopus 로고    scopus 로고
    • Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein
    • Ligeti E., Dagher M. C., Hernandez S. E., Koleske A. J. and Settleman J. (2004) Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein. J. Biol. Chem. 279, 5055-5058.
    • (2004) J. Biol. Chem. , vol.279 , pp. 5055-5058
    • Ligeti, E.1    Dagher, M.C.2    Hernandez, S.E.3    Koleske, A.J.4    Settleman, J.5
  • 28
    • 0030878997 scopus 로고    scopus 로고
    • Gelsolin binding to phosphatidylinositol 4,5-bisphosphate is modulated by calcium and pH
    • Lin K.-M., Wenegieme E., Lu P.-J., Chen C.-S. and Yin H. L. (1997) Gelsolin binding to phosphatidylinositol 4,5-bisphosphate is modulated by calcium and pH. J. Biol. Chem. 272, 20 443-20 450.
    • (1997) J. Biol. Chem. , vol.272
    • Lin, K.-M.1    Wenegieme, E.2    Lu, P.-J.3    Chen, C.-S.4    Yin, H.L.5
  • 29
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphat, is essential for vascular maturation
    • Liu Y., Wada R., Yamashita T. et al. (2000) Edg-1, the G protein-coupled receptor for sphingosine-1-phosphat, is essential for vascular maturation. J. Clin. Invest. 106, 951-961.
    • (2000) J. Clin. Invest. , vol.106 , pp. 951-961
    • Liu, Y.1    Wada, R.2    Yamashita, T.3
  • 30
    • 0032562675 scopus 로고    scopus 로고
    • Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis
    • Majumdar M., Seasholtz T. M., Goldstein D., de Lanerolle P. and Brown J. H. (1998) Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis. J. Biol. Chem. 273, 10 099-10 106.
    • (1998) J. Biol. Chem. , vol.273
    • Majumdar, M.1    Seasholtz, T.M.2    Goldstein, D.3    De Lanerolle, P.4    Brown, J.H.5
  • 32
    • 2642640420 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates actomyosin contraction in astrocytes
    • Manning T. J. Jr, Rosenfeld S. S. and Sontheimer H. (1998) Lysophosphatidic acid stimulates actomyosin contraction in astrocytes. J. Neurosci. Res. 53, 343-352.
    • (1998) J. Neurosci. Res. , vol.53 , pp. 343-352
    • Manning Jr., T.J.1    Rosenfeld, S.S.2    Sontheimer, H.3
  • 33
    • 0021809646 scopus 로고
    • Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization
    • Masters S. B., Martin M. W., Harden T. K. and Brown J. H. (1985) Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem. J. 227, 933-937.
    • (1985) Biochem. J. , vol.227 , pp. 933-937
    • Masters, S.B.1    Martin, M.W.2    Harden, T.K.3    Brown, J.H.4
  • 34
    • 0029815611 scopus 로고    scopus 로고
    • N-WASP,a novel actin-deploymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
    • Miki H., Miura K. and Takenawa T. (1996) N-WASP,a novel actin-deploymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 15, 5326-5335.
    • (1996) EMBO J. , vol.15 , pp. 5326-5335
    • Miki, H.1    Miura, K.2    Takenawa, T.3
  • 35
    • 0028961293 scopus 로고
    • Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes C. D. and Hall A. (1995) Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 37
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    • Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H. and Takuwa Y. (2000) Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell Biol. 20, 9247-9261.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 9247-9261
    • Okamoto, H.1    Takuwa, N.2    Yokomizo, T.3    Sugimoto, N.4    Sakurada, S.5    Shigematsu, H.6    Takuwa, Y.7
  • 42
    • 0032534510 scopus 로고    scopus 로고
    • Regulation of astrocyte morphology by RhoA and lysophosphatidic acid
    • Ramakers G. J. and Moolenaar W. H. (1998) Regulation of astrocyte morphology by RhoA and lysophosphatidic acid. Exp. Cell Res. 245, 252-262.
    • (1998) Exp. Cell Res. , vol.245 , pp. 252-262
    • Ramakers, G.J.1    Moolenaar, W.H.2
  • 43
    • 0034695461 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
    • Raucher D., Stauffer T., Chen W., Shen K., Guo S., York J. D., Sheetz M. P. and Meyer T. (2000) Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100, 221-228.
    • (2000) Cell , vol.100 , pp. 221-228
    • Raucher, D.1    Stauffer, T.2    Chen, W.3    Shen, K.4    Guo, S.5    York, J.D.6    Sheetz, M.P.7    Meyer, T.8
  • 44
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • Ren X.-D., Kiosses W. B. and Schwartz M. A. (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585.
    • (1999) EMBO J. , vol.18 , pp. 578-585
    • Ren, X.-D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 45
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley A. J. and Hall A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 46
    • 0028321785 scopus 로고
    • Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase
    • Ridley A. J. and Hall A. (1994) Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J. 13, 2600-2610.
    • (1994) EMBO J. , vol.13 , pp. 2600-2610
    • Ridley, A.J.1    Hall, A.2
  • 47
    • 0033577975 scopus 로고    scopus 로고
    • Interplay between Rac and Rho in the control of substrate contact dynamics
    • Rottner K., Hall A. and Small J. V. (1999) Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9, 640-648.
    • (1999) Curr. Biol. , vol.9 , pp. 640-648
    • Rottner, K.1    Hall, A.2    Small, J.V.3
  • 49
    • 0030981640 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments
    • Sakisaka T., Itoh T., Miura K. and Takenawa T. (1997) Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Mol. Cell Biol. 17, 3841-3849.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 3841-3849
    • Sakisaka, T.1    Itoh, T.2    Miura, K.3    Takenawa, T.4
  • 50
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • Sander E. E., ten Klooster J. P., van Delft S., van der Kammen R. A. and Collard J. G. (1999) Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147, 1009-1021.
    • (1999) J. Cell Biol. , vol.147 , pp. 1009-1021
    • Sander, E.E.1    Ten Klooster, J.P.2    Van Delft, S.3    Van Der Kammen, R.A.4    Collard, J.G.5
  • 51
    • 0029795850 scopus 로고    scopus 로고
    • Dynamics of capping protein and actin assembly in vitro: Uncapping barbed ends by polyphosphoinositides
    • Schafer D. A., Jennings P. B. and Cooper J. A. (1996) Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J. Cell Biol. 135, 169-179.
    • (1996) J. Cell Biol. , vol.135 , pp. 169-179
    • Schafer, D.A.1    Jennings, P.B.2    Cooper, J.A.3
  • 52
    • 0033612371 scopus 로고    scopus 로고
    • Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
    • Seasholtz T. M., Majumdar M., Kaplan D. D. and Brown J. H. (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ. Res. 84, 1186-1193.
    • (1999) Circ. Res. , vol.84 , pp. 1186-1193
    • Seasholtz, T.M.1    Majumdar, M.2    Kaplan, D.D.3    Brown, J.H.4
  • 55
    • 0031004866 scopus 로고    scopus 로고
    • Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo
    • Shibasaki Y., Ishihara H., Kizuki N., Asano T., Oka Y. and Yazaki Y. (1997) Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J. Biol. Chem. 272, 7578-7581.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7578-7581
    • Shibasaki, Y.1    Ishihara, H.2    Kizuki, N.3    Asano, T.4    Oka, Y.5    Yazaki, Y.6
  • 56
    • 0035313263 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42
    • Soede R. D., Zeelenberg I. S., Wijnands Y. M., Kamp M. and Roos E. (2001) Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. J. Immunol. 166, 4293-4301.
    • (2001) J. Immunol. , vol.166 , pp. 4293-4301
    • Soede, R.D.1    Zeelenberg, I.S.2    Wijnands, Y.M.3    Kamp, M.4    Roos, E.5
  • 57
    • 0037370012 scopus 로고    scopus 로고
    • Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated down-stream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
    • Sugimoto N., Takuwa N., Okamoto H., Sakurada S. and Takuwa Y. (2003) Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated down-stream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol. Cell Biol. 23, 1534-1545.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 1534-1545
    • Sugimoto, N.1    Takuwa, N.2    Okamoto, H.3    Sakurada, S.4    Takuwa, Y.5
  • 58
    • 0026795116 scopus 로고
    • Lysophosphatidates bound to serm albumin activate membrane currents in Xenopus oocytes and neunte retraction in pe12 pheochromocytoma cells
    • Tigyi G. and Miledi R. (1992) Lysophosphatidates bound to serm albumin activate membrane currents in Xenopus oocytes and neunte retraction in pe12 pheochromocytoma cells. J. Biol. Chem. 267, 21 360-21 367.
    • (1992) J. Biol. Chem. , vol.267
    • Tigyi, G.1    Miledi, R.2
  • 60
    • 0035794190 scopus 로고    scopus 로고
    • Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading
    • Ueda H., Morishita R., Yamauchi J., Itoh H., Kato K. and Asano T. (2001) Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading. J. Biol. Chem. 276, 6846-6852.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6846-6852
    • Ueda, H.1    Morishita, R.2    Yamauchi, J.3    Itoh, H.4    Kato, K.5    Asano, T.6
  • 61
    • 0347520943 scopus 로고    scopus 로고
    • Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiaml
    • Van Leeuwen F. N., Olivo C., Grivell S., Giepmans B. N., Collard J. G. and Moolenaar W. H. (2003) Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiaml. J. Biol. Chem. 278, 400-406.
    • (2003) J. Biol. Chem. , vol.278 , pp. 400-406
    • Van Leeuwen, F.N.1    Olivo, C.2    Grivell, S.3    Giepmans, B.N.4    Collard, J.G.5    Moolenaar, W.H.6
  • 62
    • 0037096160 scopus 로고    scopus 로고
    • Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells
    • Vouret-Craviari V., Bourcier C., Boulter E. and Obberghen-Schilling E. (2002) Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. J. Cell Sci. 115, 2475-2484.
    • (2002) J. Cell Sci. , vol.115 , pp. 2475-2484
    • Vouret-Craviari, V.1    Bourcier, C.2    Boulter, E.3    Obberghen-Schilling, E.4
  • 63
    • 0032570702 scopus 로고    scopus 로고
    • Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells
    • Willars G. B., Nahorski S. R. and Challiss R. A. (1998) Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells. J. Biol. Chem. 273, 5037-5046.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5037-5046
    • Willars, G.B.1    Nahorski, S.R.2    Challiss, R.A.3
  • 64
    • 0942275690 scopus 로고    scopus 로고
    • KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA
    • Zeng H., Zhao D. and Mukhopadhyay D. (2002) KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA. J. Biol. Chem. 277, 46 791-46 798.
    • (2002) J. Biol. Chem. , vol.277
    • Zeng, H.1    Zhao, D.2    Mukhopadhyay, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.