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Volumn 113, Issue 9, 2005, Pages 1257-1262

Aging and the environment: A research framework

Author keywords

Aging; Environmental health; Exposure; Frailty; Microenvironment; Older adults; Pharmacodynamics; Pharmacokinetics; Polypharmacy

Indexed keywords

ENVIRONMENTAL CHEMICAL; PESTICIDE; XENOBIOTIC AGENT;

EID: 25844439617     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7569     Document Type: Article
Times cited : (118)

References (90)
  • 1
    • 25844505041 scopus 로고    scopus 로고
    • Overview of oxidative stress and cancer
    • (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific
    • Akman S. 2003. Overview of oxidative stress and cancer. In: Critical Reviews of Oxidative Stress and Aging (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific, 925-954.
    • (2003) Critical Reviews of Oxidative Stress and Aging , pp. 925-954
    • Akman, S.1
  • 3
    • 2442440042 scopus 로고    scopus 로고
    • Who is sensitive to the effects of particulate air pollution on mortality? A case-crossover analysis of effect modifiers
    • Bateson TF, Schwartz J. 2004. Who is sensitive to the effects of particulate air pollution on mortality? A case-crossover analysis of effect modifiers. Epidemiology 15:143-149.
    • (2004) Epidemiology , vol.15 , pp. 143-149
    • Bateson, T.F.1    Schwartz, J.2
  • 4
    • 0025809610 scopus 로고
    • Pharmacokinetic basis of age-related changes in sensitivity to toxicants
    • Birnbaum L. 1991. Pharmacokinetic basis of age-related changes in sensitivity to toxicants. Annu Rev Pharmacol 31:101-128.
    • (1991) Annu. Rev. Pharmacol. , vol.31 , pp. 101-128
    • Birnbaum, L.1
  • 5
    • 0026060585 scopus 로고
    • Comparative aspects on the bioaccumulation, metabolism, and toxicity with PCBs
    • Borlakoglu J, Haegele K. 1991. Comparative aspects on the bioaccumulation, metabolism, and toxicity with PCBs. Comp Biochem Physiol C100:327-338.
    • (1991) Comp. Biochem. Physiol. , vol.C100 , pp. 327-338
    • Borlakoglu, J.1    Haegele, K.2
  • 6
    • 0036239153 scopus 로고    scopus 로고
    • A conceptual framework of frailty: A review
    • Bortz WM II. 2002. A conceptual framework of frailty: a review. J Gerontol 57A:M283-M288.
    • (2002) J. Gerontol. , vol.57 A
    • Bortz II, W.M.1
  • 7
    • 0033608811 scopus 로고    scopus 로고
    • Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss
    • Brooks A, Chadwick C, Gelbard H, Cory-Slechta D, Federoff H. 1999. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res 823:1-10.
    • (1999) Brain Res. , vol.823 , pp. 1-10
    • Brooks, A.1    Chadwick, C.2    Gelbard, H.3    Cory-Slechta, D.4    Federoff, H.5
  • 8
    • 0036841884 scopus 로고    scopus 로고
    • Ultrafine particle deposition and clearance in the healthy and obstructed lung
    • Brown J, Zeman K, Bennett W. 2002. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 166:1240-1247.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , pp. 1240-1247
    • Brown, J.1    Zeman, K.2    Bennett, W.3
  • 9
    • 0037291881 scopus 로고    scopus 로고
    • CYP-specific bioactivation of four organophosphorous pesticides by human liver microsomes
    • Buratti F, Volpe M, Meneguz A, Vittozzi L, Testai E. 2003. CYP-specific bioactivation of four organophosphorous pesticides by human liver microsomes. Toxicol Appl Pharmacol 186:143-154.
    • (2003) Toxicol. Appl. Pharmacol. , vol.186 , pp. 143-154
    • Buratti, F.1    Volpe, M.2    Meneguz, A.3    Vittozzi, L.4    Testai, E.5
  • 10
    • 0030893296 scopus 로고    scopus 로고
    • Biotransformation of parathion in human liver: Participation of CYP3A4 and its inactivation during microsomal parathion oxidation
    • Butler A, Murray M. 1997. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J Pharmacol Exp Ther 280:966-973.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 966-973
    • Butler, A.1    Murray, M.2
  • 11
    • 25844458940 scopus 로고
    • Clean Air Act of 1970. 42 U.S.C. s/s 7401 et. seq. Public law 91-604. [accessed 18 July 2005]
    • Clean Air Act of 1970. 1970. 42 U.S.C. s/s 7401 et. seq. Public law 91-604. http://www.epa.gov/epahome/laws.htm [accessed 18 July 2005].
    • (1970)
  • 12
    • 1942458255 scopus 로고    scopus 로고
    • Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry
    • Clewell H, Gentry P, Covington TR, Sarangapani R, Teeguarden JG. 2004. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Toxicol Sci 79:381-393.
    • (2004) Toxicol. Sci. , vol.79 , pp. 381-393
    • Clewell, H.1    Gentry, P.2    Covington, T.R.3    Sarangapani, R.4    Teeguarden, J.G.5
  • 13
    • 0036398887 scopus 로고    scopus 로고
    • Review and evaluation of the potential impact of age-and gender-specific pharmacokinetic differences on tissue dosimtry
    • Clewell H, Teeguarden J, McDonald T, Sarangapani R, Lawrence G, Covington R, et al. 2002. Review and evaluation of the potential impact of age-and gender-specific pharmacokinetic differences on tissue dosimtry. Crit Rev Toxicol 32:329-389.
    • (2002) Crit. Rev. Toxicol. , vol.32 , pp. 329-389
    • Clewell, H.1    Teeguarden, J.2    McDonald, T.3    Sarangapani, R.4    Lawrence, G.5    Covington, R.6
  • 14
    • 0141679219 scopus 로고    scopus 로고
    • What's different about older people?
    • Crome P. 2003. What's different about older people? Toxicology 192:49-54.
    • (2003) Toxicology , vol.192 , pp. 49-54
    • Crome, P.1
  • 15
    • 0036141548 scopus 로고    scopus 로고
    • The aged epidermal permeability barrier: Basis for functional abnormalities
    • Elias P, Ghadially R. 2002. The aged epidermal permeability barrier: basis for functional abnormalities. Clin Geriatric Med 18:103-120.
    • (2002) Clin. Geriatric. Med. , vol.18 , pp. 103-120
    • Elias, P.1    Ghadially, R.2
  • 16
    • 0004243736 scopus 로고    scopus 로고
    • Food Quality Protection Act of 1996
    • Food Quality Protection Act of 1996. 1996. Public Law 104-170.
    • (1996) Public Law , pp. 104-170
  • 18
    • 0028132807 scopus 로고
    • A neuroendocrine overview of aging
    • Frohman L. 1994. A neuroendocrine overview of aging. Neurobiol Aging 15:479-484.
    • (1994) Neurobiol. Aging , vol.15 , pp. 479-484
    • Frohman, L.1
  • 19
    • 0028960479 scopus 로고
    • Aged epidermal permeability barrier: Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model
    • Ghadially R, Brown B, Sequeira-Martin S, Feingold K, Elias P. 1995. Aged epidermal permeability barrier: structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 95:2281-2290.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2281-2290
    • Ghadially, R.1    Brown, B.2    Sequeira-Martin, S.3    Feingold, K.4    Elias, P.5
  • 21
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich F, Shimada T. 1991. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol 4:391-407.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 391-407
    • Guengerich, F.1    Shimada, T.2
  • 22
    • 0029337445 scopus 로고
    • P-glycoprotein expression and regulation
    • Gupta S. 1995. P-glycoprotein expression and regulation. Drugs Aging 7:19-29.
    • (1995) Drugs Aging , vol.7 , pp. 19-29
    • Gupta, S.1
  • 23
    • 0141835028 scopus 로고    scopus 로고
    • All in your mind. Science aging knowledge
    • Available: [accessed 15 February 2005]
    • Helmuth L. 2003. All in your mind. Science aging knowledge. Environ 8:3-9. Available: http://sagoke.sciencemag.org/cgi/content/full/sageke;2003/8/ns3 [accessed 15 February 2005].
    • (2003) Environ , vol.8 , pp. 3-9
    • Helmuth, L.1
  • 26
    • 0026910376 scopus 로고
    • Activity patterns of Californians: Use of and proximity to indoor pollutant sources
    • Jenkins P, Phillips T, Mulberg E, Hui S. 1992. Activity patterns of Californians: use of and proximity to indoor pollutant sources. Atmosph Environ 26A:2141-2148.
    • (1992) Atmosph. Environ. , vol.26 A , pp. 2141-2148
    • Jenkins, P.1    Phillips, T.2    Mulberg, E.3    Hui, S.4
  • 28
    • 0030984232 scopus 로고    scopus 로고
    • Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease
    • Kim C, Kang T. 1997. Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease. Am J Respir Crit Care Med 155:899-905.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 899-905
    • Kim, C.1    Kang, T.2
  • 31
    • 0004206646 scopus 로고    scopus 로고
    • Analysis of the National Human Activity Pattern Survey (NHAPS) Respondents from a Standpoint of Exposure Assessment
    • EPA/600/R-96/074. Washington, DC:U.S. Environmental Protection Agency
    • Klepeis, NE, Tsang, AM, and Behar, JV. 1996. Analysis of the National Human Activity Pattern Survey (NHAPS) Respondents from a Standpoint of Exposure Assessment. EPA/600/R-96/074. Washington, DC:U.S. Environmental Protection Agency.
    • (1996)
    • Klepeis, N.E.1    Tsang, A.M.2    Behar, J.V.3
  • 32
    • 0005958360 scopus 로고    scopus 로고
    • Reactive oxygen species and antioxidant homeostasis in neurotoxicology
    • (Tilson HA, Harry G, eds). Target Organ Toxicology Series. Philadelphia:Taylor and Francis
    • Kodavanti PRS. 1999. Reactive oxygen species and antioxidant homeostasis in neurotoxicology. In: Neurotoxicology (Tilson HA, Harry G, eds). Target Organ Toxicology Series. Philadelphia:Taylor and Francis, 157-178.
    • (1999) Neurotoxicology , pp. 157-178
    • Kodavanti, P.R.S.1
  • 33
    • 0038691960 scopus 로고    scopus 로고
    • The U.S. Environmental Protection Agency particulate matter health effects research centers program: A midcourse report of status, progress, and plans
    • Lippman M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutradis P, et al. 2003. The U.S. Environmental Protection Agency particulate matter health effects research centers program: a midcourse report of status, progress, and plans. Environ Health Perspect 111:1074-1092.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1074-1092
    • Lippman, M.1    Frampton, M.2    Schwartz, J.3    Dockery, D.4    Schlesinger, R.5    Koutradis, P.6
  • 34
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the aging human brain
    • Lu T, Pan Y, Kao S-Y, Li C, Kohane I, Chan J, et al. 2004. Gene regulation and DNA damage in the aging human brain. Nature 429:883-891.
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.-Y.3    Li, C.4    Kohane, I.5    Chan, J.6
  • 35
    • 0028652406 scopus 로고
    • Pharmacokinetics in the elderly
    • Mayersohn M. 1994. Pharmacokinetics in the elderly. Environ Health Perspect 102:119-124.
    • (1994) Environ. Health Perspect. , vol.102 , pp. 119-124
    • Mayersohn, M.1
  • 36
    • 0346242527 scopus 로고    scopus 로고
    • Oxidative stress related disease - Overview
    • (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific
    • McCord J. 2003. Oxidative stress related disease - overview. In: Critical Reviews of Oxidative Stress and Aging (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific, 883-895.
    • (2003) Critical Reviews of Oxidative Stress and Aging , pp. 883-895
    • McCord, J.1
  • 37
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean AJ, LeCouteur DG. 2004. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56:163-184.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 163-184
    • McLean, A.J.1    LeCouteur, D.G.2
  • 38
    • 0025551594 scopus 로고
    • Age-related differences in the recovery rate of brain cholinesterases, choline acetyltransferase and muscarinic acetylcholine receptor sites after a subacute intoxication of rats with the anticholinesterase agent, isofluorophate
    • Michalek H, Fortuna S, Volpe MT, Pintor A. 1990. Age-related differences in the recovery rate of brain cholinesterases, choline acetyltransferase and muscarinic acetylcholine receptor sites after a subacute intoxication of rats with the anticholinesterase agent, isofluorophate. ACTA Neurobiol Exp 50:237-249.
    • (1990) Acta Neurobiol. Exp. , vol.50 , pp. 237-249
    • Michalek, H.1    Fortuna, S.2    Volpe, M.T.3    Pintor, A.4
  • 39
    • 0030890905 scopus 로고    scopus 로고
    • Central nervous system complications of diabetes milletus - A perspective from the blood-brain barrier
    • Mooradian A. 1997. Central nervous system complications of diabetes milletus - a perspective from the blood-brain barrier. Brain Res Rev 23:210-218.
    • (1997) Brain Res. Rev. , vol.23 , pp. 210-218
    • Mooradian, A.1
  • 40
    • 25844495346 scopus 로고    scopus 로고
    • Differential Susceptibility of Older Persons to Environmental Hazards
    • NAS. Washington, DC:National Academy of Sciences. Available: [accessed 15 February 2005]
    • NAS. 2003. Differential Susceptibility of Older Persons to Environmental Hazards. Washington, DC:National Academy of Sciences. Available: http://www.epa.gov/aging/agenda/index.htm [accessed 15 February 2005].
    • (2003)
  • 41
    • 0344567413 scopus 로고
    • National Research Council. Washington, DC:National Academy Press
    • National Research Council. 1987. Aging in Today's Environment. Washington, DC:National Academy Press.
    • (1987) Aging in Today's Environment
  • 42
    • 0038023103 scopus 로고    scopus 로고
    • The elderly and waterborne Cryptosporidium infection: Gastroenteritis hospitalizations before and during the 1993 Milwaukee outbreak
    • Naumova E, Egorov A, Morris R, Griffiths J. 2003. The elderly and waterborne Cryptosporidium infection: gastroenteritis hospitalizations before and during the 1993 Milwaukee outbreak. Emerg Infect Dis 9:418-425.
    • (2003) Emerg. Infect. Dis. , vol.9 , pp. 418-425
    • Naumova, E.1    Egorov, A.2    Morris, R.3    Griffiths, J.4
  • 43
    • 0012642273 scopus 로고    scopus 로고
    • Pharmacokinetics
    • (Crome P, Ford G, eds). London:Imperial College Press
    • O'Mahoney S. 2000. Pharmacokinetics. In: Drugs and the Older Population (Crome P, Ford G, eds). London:Imperial College Press, 58-89
    • (2000) Drugs and the Older Population , pp. 58-89
    • O'Mahoney, S.1
  • 44
    • 25844432858 scopus 로고    scopus 로고
    • The aging mind: An overview
    • Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 15 February 2005]
    • Park DC. 2002. The aging mind: an overview. In: Differential Susceptibility of Older Persons to Environmental Hazards. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/aging/agenda/index.htm [accessed 15 February 2005].
    • (2002) Differential Susceptibility of Older Persons to Environmental Hazards
    • Park, D.C.1
  • 45
    • 33947643460 scopus 로고    scopus 로고
    • Polypharmacy in the elderly: Clinical challenges in emergency practice: Part I: Overview, etiology, and drug interactions
    • Available: [accessed 5 January 2004]
    • Prybys KM, Melville KA, Hanna JR, Gee A, Chyka PA. 2002 Polypharmacy in the elderly: clinical challenges in emergency practice: part I: overview, etiology, and drug interactions. Emerg Med Rep 23(11). Available: http://www.ahcpub.com/ahc_online/emr.html [accessed 5 January 2004].
    • (2002) Emerg. Med. Rep. , vol.23 , Issue.11
    • Prybys, K.M.1    Melville, K.A.2    Hanna, J.R.3    Gee, A.4    Chyka, P.A.5
  • 46
    • 0034849917 scopus 로고    scopus 로고
    • The influence of human activity patterns on personal PM exposure: A comparative analysis of filter-based and continuous particle measurements
    • Rea A, Zufall M, Williams R, Sheldon L, Howard-Reed C. 2001. The influence of human activity patterns on personal PM exposure: a comparative analysis of filter-based and continuous particle measurements. J Air Waste Manage Assoc 51:1271-1279.
    • (2001) J. Air Waste Manage. Assoc. , vol.51 , pp. 1271-1279
    • Rea, A.1    Zufall, M.2    Williams, R.3    Sheldon, L.4    Howard-Reed, C.5
  • 47
    • 25844439302 scopus 로고    scopus 로고
    • Roles of oxidative stress and other novel risk factors in cardiovascular disease
    • (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific
    • Reaven P. 2003. Roles of oxidative stress and other novel risk factors in cardiovascular disease. In: Critical Reviews of Oxidative Stress and Aging (Cutler R, Rodriguez H, eds). Hackensack, NJ:World Scientific, 896-924.
    • (2003) Critical Reviews of Oxidative Stress and Aging , pp. 896-924
    • Reaven, P.1
  • 48
    • 0034857281 scopus 로고    scopus 로고
    • Neuroendocrinology of ageing
    • Rehman H, Masson E. 2001. Neuroendocrinology of ageing. Age Ageing 30:279-287.
    • (2001) Age Ageing , vol.30 , pp. 279-287
    • Rehman, H.1    Masson, E.2
  • 49
    • 0034982956 scopus 로고    scopus 로고
    • The relationships between PM exposures for elderly populations and indoor and outdoor concentrations for three retirement center scenarios
    • Rodes C, Lawless P, Evans G, Sheldon L, Williams R, Vette A, et al. 2001. The relationships between PM exposures for elderly populations and indoor and outdoor concentrations for three retirement center scenarios. J Expo Anal Environ Epidemiol 11:103-115.
    • (2001) J. Expo. Anal. Environ. Epidemiol. , vol.11 , pp. 103-115
    • Rodes, C.1    Lawless, P.2    Evans, G.3    Sheldon, L.4    Williams, R.5    Vette, A.6
  • 50
    • 0028303820 scopus 로고
    • Plasma protein binding displacement interactions - Why are they still regarded as clinically important?
    • Rolan RE. 1994. Plasma protein binding displacement interactions - why are they still regarded as clinically important? Br J Clin Pharmacol 37:125-128.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 125-128
    • Rolan, R.E.1
  • 51
    • 0344862056 scopus 로고    scopus 로고
    • Exposure of population and microenvironmental distributions of volatile organic compound concentrations in the EXPOLIS study
    • Saarela K, Tirkkonen T, Laine-Ylijoki J, Jurvelin J, Nieuwenhuijsen M, Jantunen M. 2003. Exposure of population and microenvironmental distributions of volatile organic compound concentrations in the EXPOLIS study. Atmosph Environ 37:5563-5575.
    • (2003) Atmosph. Environ. , vol.37 , pp. 5563-5575
    • Saarela, K.1    Tirkkonen, T.2    Laine-Ylijoki, J.3    Jurvelin, J.4    Nieuwenhuijsen, M.5    Jantunen, M.6
  • 52
    • 25844474565 scopus 로고
    • Safe Drinking Water Act of 1974. 42 U.S.C. s/s 300f et seq. Public law 93-523. Available: [accessed 18 July 2005]
    • Safe Drinking Water Act of 1974. 1974. 42 U.S.C. s/s 300f et seq. Public law 93-523. Available: http://www.epa.gov/epahome/laws.htm [accessed 18 July 2005].
    • (1974)
  • 53
    • 0034674894 scopus 로고    scopus 로고
    • Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes
    • Sams C, Mason H, Rawbone R. 2000. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol Lett 116:217-221.
    • (2000) Toxicol. Lett. , vol.116 , pp. 217-221
    • Sams, C.1    Mason, H.2    Rawbone, R.3
  • 54
    • 0022197022 scopus 로고
    • Aging and drug disposition: An update
    • Schmucker D. 1985. Aging and drug disposition: an update. Pharmacol Rev 37:133-148.
    • (1985) Pharmacol. Rev. , vol.37 , pp. 133-148
    • Schmucker, D.1
  • 56
    • 0035695389 scopus 로고    scopus 로고
    • Liver function and phase I drug metabolism in the elderly
    • Schmucker D. 2001. Liver function and phase I drug metabolism in the elderly. Drugs Aging 18:837-851.
    • (2001) Drugs Aging , vol.18 , pp. 837-851
    • Schmucker, D.1
  • 58
    • 0030812065 scopus 로고    scopus 로고
    • Age-related changes in the blood-brain barrier
    • Shah G, Mooradian A. 1997. Age-related changes in the blood-brain barrier. Exp Geronotol 32:501-519.
    • (1997) Exp. Geronotol. , vol.32 , pp. 501-519
    • Shah, G.1    Mooradian, A.2
  • 59
    • 0028237729 scopus 로고
    • Interindividual variations in human live cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich F. 1994. Interindividual variations in human live cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.5
  • 60
    • 17044380815 scopus 로고    scopus 로고
    • Molecular endocrinology and physiology of the aging central nervous system
    • Smith RG, Betancourt L, Sun Y. 2005. Molecular endocrinology and physiology of the aging central nervous system. Endocr Rev 26:203-250.
    • (2005) Endocr. Rev. , vol.26 , pp. 203-250
    • Smith, R.G.1    Betancourt, L.2    Sun, Y.3
  • 61
    • 25844518379 scopus 로고
    • Chemical time bombs: Environmental causes of neurodegenerative diseases
    • (Russell R, Flattau P, Pope A, eds). Washington, DC:National Academy Press
    • Spencer PS. 1990. Chemical time bombs: environmental causes of neurodegenerative diseases. In: Behavioral Measures of Neurotoxicity (Russell R, Flattau P, Pope A, eds). Washington, DC:National Academy Press, 268-284.
    • (1990) Behavioral Measures of Neurotoxicity , pp. 268-284
    • Spencer, P.S.1
  • 62
    • 0022107637 scopus 로고
    • Personal exposures to respirable particles and implications for air pollution epidemiology
    • Spengler J, Treitman R, Mage D, Soczek M. 1985. Personal exposures to respirable particles and implications for air pollution epidemiology. Environ Sci Technol 19:700-707.
    • (1985) Environ. Sci. Technol. , vol.19 , pp. 700-707
    • Spengler, J.1    Treitman, R.2    Mage, D.3    Soczek, M.4
  • 64
    • 0042421940 scopus 로고    scopus 로고
    • Age-related irreversible progressive nigrastriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype
    • Thiruchelvam M, McCormack A, Richfield E, Baggs R, Tank A, Di Monte D, et al. 2003. Age-related irreversible progressive nigrastriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur J Neurosci 18:589-600.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 589-600
    • Thiruchelvam, M.1    McCormack, A.2    Richfield, E.3    Baggs, R.4    Tank, A.5    Di Monte, D.6
  • 65
    • 0031748173 scopus 로고    scopus 로고
    • In vitro and in vivo drug interactions involving human CYP3A
    • Thummel K, Wilkinson G. 1998. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 38:389-430.
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 389-430
    • Thummel, K.1    Wilkinson, G.2
  • 66
    • 0003884696 scopus 로고    scopus 로고
    • A Profile of Older Americans: 2003
    • U.S. AoA. Washington, DC:U.S. Administration on Aging. Available: [accessed 16 February 2005]
    • U.S. AoA. 2004. A Profile of Older Americans: 2003. Washington, DC:U.S. Administration on Aging. Available: http://www.aoa.gov/prof/Statistics/profile/2003/2003profile.pdf [accessed 16 February 2005].
    • (2004)
  • 67
    • 0003460177 scopus 로고    scopus 로고
    • Population Projections of the United States by age, sex, race, and Hispanic origin: 1995 to 2050
    • U.S. DoC. Current Population Reports, P25-1130. Washington, DC:U.S. Department of Commerce. Available: [accessed 16 February 2005]
    • U.S. DoC. 1996. Population Projections of the United States by age, sex, race, and Hispanic origin: 1995 to 2050. Current Population Reports, P25-1130. Washington, DC:U.S. Department of Commerce. Available: http://www.consus.gov/prod/1/pop/p25-1130/p251130.pdf [accessed 16 February 2005].
    • (1996)
  • 68
    • 0003432401 scopus 로고    scopus 로고
    • U.S. EPA. EPA/600/P-95/002Fa. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. 1997. Exposure Factors Handbook. EPA/600/P-95/002Fa. Washington, DC:U.S. Environmental Protection Agency.
    • (1997) Exposure Factors Handbook
  • 69
    • 2542446007 scopus 로고    scopus 로고
    • A comparison of indoor and outdoor concentrations of hazardous air pollutants
    • U.S. EPA. EPA/600/N-98/002. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. 1998. A comparison of indoor and outdoor concentrations of hazardous air pollutants. EPA/600/N-98/002. Washington, DC:U.S. Environmental Protection Agency.
    • (1998)
  • 70
    • 0003506609 scopus 로고    scopus 로고
    • U.S. EPA. EPA/600/R-00/068. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development
    • U.S. EPA. 2000. Strategy for Research on Environmental Risks to Children. EPA/600/R-00/068. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development.
    • (2000) Strategy for Research on Environmental Risks to Children
  • 71
    • 25844490389 scopus 로고    scopus 로고
    • A national agenda for the environment and the aging: Setting priorities for research and education to address environmental hazards the threaten the health of older persons
    • U.S. EPA
    • U.S. EPA. 2003a. A national agenda for the environment and the aging: setting priorities for research and education to address environmental hazards the threaten the health of older persons. Fed Reg 68(42):10238-10240.
    • (2003) Fed. Reg. , vol.68 , Issue.42 , pp. 10238-10240
  • 72
    • 2642582310 scopus 로고    scopus 로고
    • EPA's Draft Report on the Environment Technical Document
    • U.S. EPA. EPA 600-R-03-050. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development and Office of Environmental Information
    • U.S. EPA. 2003b. EPA's Draft Report on the Environment Technical Document. EPA 600-R-03-050. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development and Office of Environmental Information.
    • (2003)
  • 73
    • 25844432857 scopus 로고    scopus 로고
    • U.S. EPA. EPA/600/R-02/050. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development
    • U.S. EPA. 2003c. Human Health Research Strategy. EPA/600/R-02/050. Washington, DC:U.S. Environmental Protection Agency, Office of Research and Development.
    • (2003) Human Health Research Strategy
  • 74
    • 25844453924 scopus 로고    scopus 로고
    • Aging Initiative: Public Listening Sessions
    • U.S. EPA U.S. Environmental Protection Agency. Available: [accessed 18 July 2005]
    • U.S. EPA 2005a. Aging Initiative: Public Listening Sessions. U.S. Environmental Protection Agency. Available: http://www.epa.gov/aging/listening/index.htm [accessed 18 July 2005].
    • (2005)
  • 76
    • 25844485860 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Washington, DC:U.S. Food and Drug Administration. Available: [accessed 15 February 2005]
    • U.S. Food and Drug Administration. 2002. Preventable Adverse Drug Reactions: A Focus on Drug Interactions. Washington, DC:U.S. Food and Drug Administration. Available: http://www.fda.gov/cder/drug/drugReactions [accessed 15 February 2005].
    • (2002) Preventable Adverse Drug Reactions: A Focus on Drug Interactions
  • 77
    • 0024603310 scopus 로고
    • Aging and determinants of hepatic drug clearance
    • Vestal R. 1989. Aging and determinants of hepatic drug clearance. Hepatology 9:331-334.
    • (1989) Hepatology , vol.9 , pp. 331-334
    • Vestal, R.1
  • 78
    • 0030931530 scopus 로고    scopus 로고
    • Aging and pharmacology
    • Vestal R. 1997. Aging and pharmacology. Cancer 80:1302-1310.
    • (1997) Cancer , vol.80 , pp. 1302-1310
    • Vestal, R.1
  • 79
    • 0006618512 scopus 로고
    • Psychotropic drug metabolism in old age: Principles and problems of assessment
    • (Bloom F, Kupfer D, eds). New York:Raven Press
    • von Moltke L, Greenblatt D, Harmatz J, Shader R. 1995. Psychotropic drug metabolism in old age: principles and problems of assessment. In: Psychopharmacology: The Fourth Generation of Progress (Bloom F, Kupfer D, eds). New York:Raven Press, 1461-1469.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 1461-1469
    • von Moltke, L.1    Greenblatt, D.2    Harmatz, J.3    Shader, R.4
  • 80
    • 0006618512 scopus 로고
    • Psychotropic drug metabolism in old age: Principles and problems of assessment
    • (Bloom F, Kupfer D, eds). New York:Raven Press
    • von Moltke L, Greenblatt D, Harmatz J, Shader R. 1995. Psychotropic drug metabolism in old age: principles and problems of assessment. In: Psychopharmacology: The Fourth Generation of Progress (Bloom F, Kupfer D, eds). New York:Raven Press, 1461-1469.
    • (1995) The Fourth Generation of Progress , pp. 1461-1469
    • von Moltke, L.1    Greenblatt, D.2    Harmatz, J.3    Shader, R.4
  • 81
    • 4544383021 scopus 로고    scopus 로고
    • Frailty - The search for underlying causes
    • pe4; dot: 10.1126/sageke.2004.4.pe4 [online 28 January 2004]. Available: [accessed 18 July 2005]
    • Walston J. 2004. Frailty - the search for underlying causes. Sci Aging Knowledge Environ pe4; dot: 10.1126/sageke.2004.4.pe4 [online 28 January 2004]. Available: http://ageke.sciencemag.org/cgi/content/full/2004/4/034 [accessed 18 July 2005].
    • (2004) Sci. Aging Knowledge Environ.
    • Walston, J.1
  • 82
    • 0037111615 scopus 로고    scopus 로고
    • Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities
    • Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, et al. 2002. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities. Arch Intern Med 162:2333-2341.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2333-2341
    • Walston, J.1    McBurnie, M.A.2    Newman, A.3    Tracy, R.P.4    Kop, W.J.5    Hirsch, C.H.6
  • 83
    • 0024987392 scopus 로고
    • Risk Assessment: The insidious nature of neurotoxicity and the aging brain
    • Weiss B. 1990. Risk Assessment: the insidious nature of neurotoxicity and the aging brain. Neurotoxicology 11:305-314.
    • (1990) Neurotoxicology , vol.11 , pp. 305-314
    • Weiss, B.1
  • 84
    • 0034257027 scopus 로고    scopus 로고
    • Indoor, outdoor, and personal exposure monitoring of particulate air pollution: The Baltimore Elderly Epidemiology-Exposure Pilot Study
    • Williams R, Creason J, Zweidinger R, Watts R, Sheldon L, Shy C. 2000a. Indoor, outdoor, and personal exposure monitoring of particulate air pollution: the Baltimore Elderly Epidemiology-Exposure Pilot Study. Atmosph Environ 34:4139-4204.
    • (2000) Atmosph. Environ. , vol.34 , pp. 4139-4204
    • Williams, R.1    Creason, J.2    Zweidinger, R.3    Watts, R.4    Sheldon, L.5    Shy, C.6
  • 85
    • 0034544689 scopus 로고    scopus 로고
    • The 1998 Baltimore Particulate Matter Epidemiology-Exposure Study. Part 2: Personal exposure assessment associated with an elderly study population
    • Williams R, Suggs J, Creason J, Rodes C, Lawless P, Kwok R, et al. 2000b. The 1998 Baltimore Particulate Matter Epidemiology-Exposure Study. Part 2: Personal exposure assessment associated with an elderly study population. J Exp Anal Environ Epidemiol 10:533-543.
    • (2000) J. Exp. Anal. Environ. Epidemiol. , vol.10 , pp. 533-543
    • Williams, R.1    Suggs, J.2    Creason, J.3    Rodes, C.4    Lawless, P.5    Kwok, R.6
  • 88
    • 0036615233 scopus 로고    scopus 로고
    • Alterations in cytokine regulation in aged epidermis: Implications for permeability barrier homeostasis and inflammation. I: IL-1 gene family
    • Ye J, Garg A, Calhoun C, Feingold K, Elias P, Ghadially R. 2002. Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I: IL-1 gene family. Exp Dermatol 11:209-216.
    • (2002) Exp. Dermatol. , vol.11 , pp. 209-216
    • Ye, J.1    Garg, A.2    Calhoun, C.3    Feingold, K.4    Elias, P.5    Ghadially, R.6
  • 89
    • 0032724260 scopus 로고    scopus 로고
    • Biology of sensescent liver peroxisomes: Role in hepatocellular aging and disease
    • Youssef J, Badr M. 1999. Biology of sensescent liver peroxisomes: role in hepatocellular aging and disease. Environ Health Perspect 107:791-797.
    • (1999) Environ. Health Perspect. , vol.107 , pp. 791-797
    • Youssef, J.1    Badr, M.2
  • 90
    • 0033756254 scopus 로고    scopus 로고
    • Are there sensitive subgroups for the effects of airborne particles?
    • Zanobetti A, Schwartz J, Gold D. 2000. Are there sensitive subgroups for the effects of airborne particles? Environ Health Perspect 108:841-845.
    • (2000) Environ. Health Perspect. , vol.108 , pp. 841-845
    • Zanobetti, A.1    Schwartz, J.2    Gold, D.3


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