Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Free Radical Biology and Medicine

Volumn 45, Issue 10, 2008, Pages 1395-1402

  Cardoso, Susana ^a   Santos, Renato X ^a   Carvalho, Cristina ^a   Correia, Sónia ^a,b   Pereira, Gonçalo C ^a,b   Pereira, Susana S ^a,b   Oliveira, Paulo J ^a,b   Santos, Maria S ^a,b   Proença, Teresa ^b,c   Moreira, Paula I ^b,d  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Brain; Doxorubicin; Free radicals; Mitochondria; Oxidative stress; Permeability transition pore

Indexed keywords

ACONITATE HYDRATASE; ALPHA TOCOPHEROL; CALCIUM ION; DOXORUBICIN; GLUTATHIONE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BRAIN MITOCHONDRION; BRAIN TOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ANIMALS; ANTIOXIDANTS; BRAIN; CALCIUM; DOXORUBICIN; GLUTATHIONE; MALE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; VITAMIN E;

ANIMALIA; RATTUS;

EID: 54349099428     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.08.008     Document Type: Article

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