A novel Ala-3Thr mutation in the signal peptide of human luteinizing hormone β-subunit: Potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathwy by recombinant variant hormone

Molecular Human Reproduction

Volumn 8, Issue 3, 2002, Pages 201-212

  Jiang, Min ^a   Lamminen, Tarja ^a   Pakarinen, Pirjo ^a   Hellman, Jukka ^a   Manna, Pulak ^a   Herrera, Rene J ^b   Huhtaniemi, Ilpo ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

LH variant; Luteinizing hormone; Mutation; PCR; Purification

Indexed keywords

ADENYLATE CYCLASE; ALANINE; AMINO ACID; CYCLIC AMP; DNA; GLYCINE; INOSITOL PHOSPHATE; INOSITOL TRISPHOSPHATE; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROGESTERONE; RECOMBINANT HORMONE; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; THREONINE;

ALPHA CHAIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA POLYMORPHISM; ENZYME SYNTHESIS; EXON; HETEROZYGOSITY; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; IN VITRO STUDY; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN VARIANT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; WILD TYPE;

ADENYLATE CYCLASE; ALANINE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CULTURE MEDIA; CYCLIC AMP; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HUMANS; INOSITOL PHOSPHATES; LUTEINIZING HORMONE; MAP KINASE SIGNALING SYSTEM; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, GENETIC; PROGESTERONE; PROTEIN SORTING SIGNALS; RECEPTORS, LH; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, PROTEIN; THREONINE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036187866     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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