NMDA receptor activation limits the number of synaptic connections during hippocampal development

Nature Neuroscience

Volumn 4, Issue 11, 2001, Pages 1102-1107

  Lüthi, Andreas ^a   Schwyzer, Lucia ^a   Mateos, José María ^a   Gähwiler, Beat H ^a   McKinney, R Anne ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CELL STRUCTURE; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NEUROMODULATION; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; SYNAPSE; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; ANIMALS, NEWBORN; CELL SURFACE EXTENSIONS; CELLS, CULTURED; DENDRITES; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HISTOCYTOCHEMISTRY; ION CHANNELS; LYSINE; MICROSCOPY, CONFOCAL; PATCH-CLAMP TECHNIQUES; PIPERAZINES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 0035707110     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn744     Document Type: Article

References (36)

1. Maturation of a central glutamatergic synapse
2. Long-term potentiation and functional synapse induction in developing hippocampus
3. Silent synapses during development of thalamocortical inputs
4. Developmental mechanisms that generate precise patterns of neuronal connectivity
5. LTP and activity-dependent synaptogenesis: The more alike they are, the more different they become
6. A synaptic model of memory: Long-term potentiation in the hippocampus
7. Long-term potentiation - A decade of progress?
8. Involvement of the N-methyl-D-aspartate (NMDA) receptor in synapse elimination during cerebellar development
9. Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex
10. What's critical for the critical period in visual cortex?
11. Regulation of morphological postsynaptic synapses in developing hippocampal neurons
12. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses
13. Assembly of new individual excitatory synapses: Time course and temporal order of synaptic molecule recruitment
14. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity
15. Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between CA3-CA1 cell pairs in vitro
16. Bidirectional associative plasticity of unitary CA3-CA1 EPSPs in the rat hippocampus in vitro
17. Quantal analysis of paired-pulse facilitation in guinea pig hippocampal slices
18. Presynaptic changes during mossy fiber LTP revealed by NMDA receptor-mediated synaptic responses
19. Dendritic spine changes associated with hippocampal long-term plasticity
20. Miniature synaptic events maintain dendritic spines via AMPA receptor activation
21. Postsynaptic calcium/calmodulin-dependent kinase II is required to limit elaboration of presynaptic and postsynaptic neuronal arbors
22. Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors
23. Activity-dependent scaling of quantal amplitude in neocortical neurons
24. A and NMDA receptors in the neonatal hippocampus
25. Developmental profile and synaptic origin of early network oscillations in the CA1 region of rat neonatal hippocampus
26. 2+-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses
27. Synaptic assembly of the brain in the absence of neurotransmitter secretion
28. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp
29. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
30. Evidence for a role of dendritic filopodia in synaptogenesis and spine formation
31. Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: Implications for the maturation of synaptic physiology and long-term potentiation
32. Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures
33. Chronic NMDA receptor blockade from birth increases the sprouting capacity of ipsilateral retinocollicular axons without disrupting their early segregation
34. Lesion-induced sprouting and hyperexcitability in the hippocampus in vitro: Implications for the genesis of posttraumatic epilepsy