Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery

Journal of Immunology

Volumn 181, Issue 8, 2008, Pages 5462-5472

  Kawamura, Kazuyuki ^a   Yao, Karen ^a   Shukaliak Quandt, Jacqueline A ^a   Huh, Jaebong ^a   Baig, Mirza ^a   Quigley, Laura ^a   Ito, Naoko ^b   Necker, Antje ^c   McFarland, Henry F ^a   Muraro, Paolo A ^a,d   Martin, Roland ^a,e   Ito, Kouichi ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c BECKMAN COULTER INC   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HD4 1C2 PROTEIN; HLA DR ANTIGEN; LYMPHOCYTE RECEPTOR; MEMBRANE PROTEIN; MS2 3C8 PROTEIN; MYELIN BASIC PROTEIN; MYELIN BASIC PROTEIN[111-129]; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; EPITOPE; HLA-DRB1 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MBP PROTEIN, HUMAN; MBP PROTEIN, MOUSE; NERVE PROTEIN; PEPTIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; IMMUNOASSAY; IMMUNOHISTOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMUS; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; MULTIPLE SCLEROSIS; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; GENE EXPRESSION; HLA-DR ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 54049145487     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.8.5462     Document Type: Article

References (47)

1. Stastny, P. 1978. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298: 869-871. (Pubitemid 8330170)
2. Grasso, M. G., F. Cutrupi, S. Bernardi, S. Trabace, C. Pozzilli, S. Cappellacci, and C. Fieschi. 1992. HLA determinants in familial multiple sclerosis. Neuroepidemiology 11: 85-89.
3. Marrosu, M. G., F. Muntoni, M. R. Murru, G. Spinicci, M. P. Pischedda, F. Goddi, P. Cossu, and M. Pirastu. 1988. Sardinian multiple sclerosis is associated with HLA-DR4: a serologic and molecular analysis. Neurology 38: 1749-1753.
4. Kurdi, A., I. Ayesh, A. Abdallat, and U. Maayta. 1977. Different B lymphocyte alloantigens associated with multiple sclerosis in Arabs and North Europeans. Lancet 1: 1123-1125. (Pubitemid 8111076)
5. Dorfman, J. R., and R. N. Germain. 2002. MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect. 4: 547-554.
6. Ito, K., H. J. Bian, M. Molina, J. Han, J. Magram, E. Saar, C. Belunis, D. R. Bolin, R. Arceo, R. Campbell, et al. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J. Exp. Med. 183: 2635-2644. (Pubitemid 26192372)
7. Touloukian, C. E., W. W. Leitner, S. L. Topalian, Y. F. Li, P. F. Robbins, S. A. Rosenberg, and N. P. Restifo. 2000. Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice. J. Immunol. 164: 3535-3542.
8. Meyer, A. L., C. Trollmo, F. Crawford, P. Marrack, A. C. Steere, B. T. Huber, J. Kappler, and D. A. Hafler. 2000. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc. Natl. Acad. Sci. USA 97: 11433-11438.
9. Forsthuber, T. G., C. L. Shive, W. Wienhold, K. de Graaf, E. G. Spack, R. Sublett, A. Melms, J. Kort, M. K. Racke, and R. Weissert. 2001. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J. Immunol. 167: 7119-7125.
10. Wang, D., J. A. Hill, A. M. Jevnikar, E. Cairns, and D. A. Bell. 2002. Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice. J. Autoimmun. 19: 37-43. (Pubitemid 35205198)
11. Tarcha, E. J., V. Basrur, C. Y. Hung, M. J. Gardner, and G. T. Cole. 2006. Multivalent recombinant protein vaccine against coccidioidomycosis. Infect. Immun. 74: 5802-5813. (Pubitemid 44484566)
12. Quandt, J. A., M. Baig, K. Yao, K. Kawamura, J. Huh, S. K. Ludwin, H. J. Bian, M. Bryant, L. Quigley, Z. A. Nagy, et al. 2004. Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice. J. Exp. Med. 200: 223-234.
13. Muraro, P. A., M. Vergelli, M. Kalbus, D. E. Banks, J. W. Nagle, L. R. Tranquill, G. T. Nepom, W. E. Biddison, H. F. McFarland, and R. Martin. 1997. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J. Clin. Invest. 100: 339-349.
14. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262: 422-424. (Pubitemid 23353384)
15. Casanova, J. L., P. Romero, C. Widmann, P. Kourilsky, and J. L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex- restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174: 1371-1383.
16. Zal, T., S. Weiss, A. Mellor, and B. Stockinger. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93: 9102-9107. (Pubitemid 26282025)
17. Sarukhan, A., C. Garcia, A. Lanoue, and H. von Boehmer. 1998. Allelic inclusion of T cell receptor α genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity 8: 563-570. (Pubitemid 28264747)
18. McGargill, M. A., J. M. Derbinski, and K. A. Hogquist. 2000. Receptor editing in developing T cells. Nat. Immunol. 1: 336-341.
19. He, X., C. A. Janeway, Jr., M. Levine, E. Robinson, P. Preston-Hurlburt, C. Viret, and K. Bottomly. 2002. Dual receptor T cells extend the immune repertoire for foreign antigens. Nat. Immunol. 3: 127-134. (Pubitemid 34141442)
20. Gebe, J. A., K. A. Unrath, B. A. Falk, K. Ito, L. Wen, T. L. Daniels, A. Lernmark, and G. T. Nepom. 2006. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin. Immunol. 121: 294-304.
21. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8: 403-411.
22. Giacomini, P., A. Ciucci, M. R. Nicotra, C. Nastruzzi, G. Feriotto, E. Appella, R. Gambari, L. Pozzi, and P. G. Natali. 1991. Tissue-specific expression of the HLA-DRA gene in transgenic mice. Immunogenetics 34: 385-391.
23. Fehling, H. J., W. van Ewijk, J. L. Pasquali, C. Waltzinger, M. Le Meur, P. Gerlinger, C. Benoist, and D. Mathis. 1990. Functional consequences of overexpressed Ia antigens in AKα/AKβ transgenic mice. J. Immunol. 144: 2865-2874.
24. Liu, H., A. J. MacKenzie-Graham, K. Palaszynski, S. Liva, and R. R. Voskuhl. 2001. "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages. J. Neuroimmunol. 116: 83-93. (Pubitemid 32322642)
25. + thymocytes and regulates positive selection. Immunity 15: 457-466.
26. Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188: 2301-2311.
27. Beverly, B., S. M. Kang, M. J. Lenardo, and R. H. Schwartz. 1992. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4: 661-671.
28. Schwartz, R. H. 2003. T cell anergy. Annu. Rev. Immunol. 21: 305-334.
29. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell 69: 529-537.
30. Hammer, J., F. Gallazzi, E. Bono, R. W. Karr, J. Guenot, P. Valsasnini, Z. A. Nagy, and F. Sinigaglia. 1995. Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J. Exp. Med. 181: 1847-1855.
31. Fritz, R. B., and I. Kalvakolanu. 1995. Thymic expression of the Golli-myelin basic protein gene in the SJL/J mouse. J. Neuroimmunol. 57: 93-99.
32. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72: 551-560. (Pubitemid 23077743)
33. Lafaille, J. J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78: 399-408.
34. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8: 571-580.
35. Bielekova, B., M. H. Sung, N. Kadom, R. Simon, H. McFarland, and R. Martin. 2004. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J. Immunol. 172: 3893-3904. (Pubitemid 38337977)
36. Williams, C. B., D. L. Engle, G. J. Kersh, J. Michael White, and P. M. Allen. 1999. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J. Exp. Med. 189: 1531-1544.
37. Ernst, B., D. S. Lee, J. M. Chang, J. Sprent, and C. D. Surh. 1999. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11: 173-181. (Pubitemid 29428810)
38. Viret, C., F. S. Wong, and C. A. Janeway, Jr. 1999. Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity 10: 559-568.
39. Beutner, U., and H. R. MacDonald. 1998. TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host. Int. Immunol. 10: 305-310. (Pubitemid 28132716)
40. Takeda, S., H. R. Rodewald, H. Arakawa, H. Bluethmann, and T. Shimizu. 1996. MHC class II molecules are not required for survival of newly generated CD4 T cells, but affect their long-term life span. Immunity 5: 217-228. (Pubitemid 26341365)
41. Kirberg, J., A. Berns, and H. von Boehmer. 1997. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex- encoded molecules. J. Exp. Med. 186: 1269-1275. (Pubitemid 27469022)
42. + thymocytes. Nature 333: 742-746.
43. + T cells. J. Exp. Med. 185: 405-414.
44. Campagnoni, A. T., T. M. Pribyl, C. W. Campagnoni, K. Kampf, S. Amur-Umarjee, C. F. Landry, V. W. Handley, S. L. Newman, B. Garbay, and K. Kitamura. 1993. Structure and developmental regulation of Golli-MBP, a 105- kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J. Biol. Chem. 268: 4930-4938. (Pubitemid 23081614)
45. Golding, H., T. Mizuochi, S. A. McCarthy, C. A. Cleveland, and A. Singer. 1987. Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants. J. Immunol. 138: 10-17. (Pubitemid 17218392)
46. Miller, R. A., and O. Stutman. 1982. Monoclonal antibody to Lyt 2 antigen blocks H-2I- and H-2K- specific mouse cytotoxic T cells. Nature 296: 76-78.
47. Heath, W. R., F. R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J. F. Miller. 1995. Expression of two T cell receptor alpha chains on the surface of normal murine T cells. Eur. J. Immunol. 25: 1617-1623.