MAPK signaling pathways are needed for survival of H9c2 cardiac myoblasts under extracellular alkalosis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Stathopoulou, Konstantina ^a   Beis, Isidoros ^a   Gaitanaki, Catherine ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cardiomyoblast; Cell death; Signal transduction

Indexed keywords

AMMONIUM CHLORIDE; BUFFER; CARIPORIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGONUCLEOTIDE; PROTEIN BCL 2; PROTEIN C JUN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ALKALINIZATION; ALKALOSIS; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; INHIBITION KINETICS; MYOBLAST; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STIMULUS; ANIMAL; BIOSYNTHESIS; CELL FRACTIONATION; DRUG EFFECT; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENETICS; IN VITRO STUDY; LUMINESCENCE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

ALKALOSIS; ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUMINESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOBLASTS; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RATS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTOR AP-1;

EID: 54049128990     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01362.2007     Document Type: Article

References (50)

1. 2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Cell Signal 18: 1801-1812, 2006.
2. + exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits. Cardiovasc Res 63: 273-282, 2004.
3. Befroy DE, Powell T, Radda GK, Clarke K. Osmotic shock: modulation of contractile function, pHi, and ischemic damage in perfused guinea pig heart. Am J Physiol Heart Circ Physiol 276: H1236-H1244, 1999.
4. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 13681-13686, 2001.
5. Bogoyevitch MA. Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular system. Cardiovasc Res 45: 826-842, 2000.
6. Bogoyevitch MA, Kobe B. Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev 70: 1061-1095, 2006.
7. Clerk A, Aggeli IK, Stathopoulou K, Sugden PH. Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes. Cell Signal 18: 225-235, 2006.
8. Dougherty CJ, Kubasiak L, Prentice H, Andreka P, Bishopric NH, Webster KA. Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress. Biochem J 362: 561-571, 2002.
9. Engelbrecht AM, Niesler C, Page C, Lochner A. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res Cardiol 99: 338-350, 2004.
10. Fuller SJ, Gaitanaki CJ, Sugden PH. Effects of increasing extracellular pH on protein synthesis and protein degradation in the perfused working rat heart. Biochem J 259: 173-179, 1989.
11. 1-adrenergic stimulation of cardiac protein synthesis may involve increased intracellular pH and protein kinase activity. Biochem J 273: 347-353, 1991.
12. Gaitanaki CJ, Sugden PH, Fuller SJ. Stimulation of protein synthesis by raised extracellular pH in cardiac myocytes and perfused hearts. FEBS Lett 260: 42-44, 1990.
13. Gaitanaki C, Stathopoulou K, Stavridou C, Beis I. Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart. J Exp Biol 206: 2759-2769, 2003.
14. L- and PKB/AKT-independent fashion. Cell Death Differ 11: 342-353, 2004.
15. Gupta P, Prywes R. ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression. J Biol Chem 277: 50550-50556, 2002.
16. + exchanger NHE1 by sustained intracellular acidosis. J Biol Chem 278: 31676-31684, 2003.
17. Hescheler J, Meyer R, Plant S, Krautwurst D, Rosenthal W, Schultz G. Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res 69: 1476-1486, 1991.
18. + exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene- induced apoptosis. Cancer Res 67: 1696-1705, 2007.
19. Ito T, Deng X, Carr B, May WS. Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272: 11671-11673, 1997.
20. 2+ exchange. Eur J Pharmacol 186: 29-40, 1990.
21. Izumi H, Torigoe T, Ishiguchi H, Uramoto H, Yoshida Y, Tanabe M, Ise T, Murakami T, Yoshida T, Nomoto M, Kohno K. Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev 29: 541-549, 2003.
22. Kefaloyianni E, Gaitanaki C, Beis I. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts. Cell Signal 18: 2238-2251, 2006.
23. Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK. Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol 21: 7545-7557, 2001.
24. + exchanger. Circ Res 68: 269-279, 1991.
25. Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001.
26. Lagadic-Gossmann D, Huc L, Lecureur V. Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell Death Differ 11: 953-961, 2004.
27. + exchanger in human pleural mesothelial cells. Am J Physiol Lung Cell Mol Physiol 274: L665-L672, 1998.
28. Liu G, Zhang Y, Bode AM, Ma YM, Dong Z. Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J Biol Chem 277: 8810-8816, 2002.
29. Miyoshi N, Uchida K, Osawa T, Nakamura Y. A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res 64: 2134-2142, 2004.
30. 2. Endothelium 13: 313-316, 2006.
31. Orchard CH, Kentish JC. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol Cell Physiol 258: C967-C981, 1990.
32. Pechtelidou A, Beis I, Gaitanaki C. Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells. Mol Cell Biochem 309: 177-189, 2008.
33. + exchanger, NHE1. Arch Biochem Biophys 462: 195-201, 2007.
34. Punn A, Mockridge JW, Farooqui S, Marber MS, Heads RJ. Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. Biochem J 350: 891-899, 2000.
35. Roos A, Boron W. Intracellular pH. Physiol Rev 61: 296-434, 1981.
36. Ruvolo PP, Deng X, May WS. Phosphorylation of Bcl-2 and regulation of apoptosis. Leukemia 15: 515-522, 2001.
37. Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U, Wang YM, Kyriakis J, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronovitz M, Tsichlis PN, Bhattacharya S, Force T, Kilter H. c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res 98: 111-118, 2006.
38. 2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism. J Biol Chem 272: 13653-13659, 1997.
39. Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JSC. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J 22: 2788-2797, 2003.
40. Stathopoulou K, Gaitanaki C, Beis I. Extracellular pH changes activate the p38-MAPK signalling pathway in the amphibian heart. J Exp Biol 209: 1344-1354, 2006.
41. Susa S, Wakabayashi I. Extracellular alkalosis activates ERK mitogen-activated protein kinase of vascular smooth muscle cells through NADPH-mediated formation of reactive oxygen species. FEBS Lett 554: 399-402, 2003.
42. Thomas JA, Buchsbaum RN, Zimniak A, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18: 2210-2218, 1979.
43. Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Sbarba PD, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F. Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem 276: 39027-39036, 2001.
44. Venkatakrishnan CD, Tewari AK, Moldovan L, Cardounel AJ, Zweier JL, Kuppusamy P, Ilangovan G. Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27. Am J Physiol Heart Circ Physiol 291: H2680-H2691, 2006.
45. Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D. JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J 22: 3686-3695, 2003.
46. Xiao D, Choi S, Johnson DE, Vogel VG, Johnson CS, Trump DL, Lee YJ, Singh SV. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 23: 5594-5606, 2004.
47. 2/M. Mol Cell Biol 19: 8469-8478, 1999.
48. Yamazaki T, Komuro I, Kudoh S, Zou Y, Nagai R, Aikawa R, Uozumi H, Yazaki Y. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res 82: 430-437, 1998.
49. Yang J, Gillingham AK, Hoel A, Koumanov F, Woodward B, Holman GD. Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes. Am J Physiol Endocrinol Metab 283: E1299-E1307, 2002.
50. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-340, 2004.