Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy

Xenobiotica

Volumn 38, Issue 10, 2008, Pages 1289-1297

  Owen, B M ^a   Van Mil, S W C ^b   Boudjelal, M ^c   McLay, I ^c   Cairns, W ^c   Elias, E ^d   White, R ^a   Williamson, C ^a   Dixon, P H ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c GLAXOSMITHKLINE   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Bile acid; Intrahepatic cholestasis of pregnancy; Pregnane X receptor (PXR); Reporter assay; Single nucleotide polymorphism

Indexed keywords

BILE ACID; DEXAMETHASONE; LITHOCHOLIC ACID; PREGNANE X RECEPTOR; RIFAMPICIN; URSODEOXYCHOLIC ACID;

ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRAHEPATIC CHOLESTASIS; MAJOR CLINICAL STUDY; PREGNANCY; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE SEQUENCE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; MOLECULAR SEQUENCE DATA; PREGNANCY; PREGNANCY COMPLICATIONS; RECEPTORS, STEROID;

EQUUS ASINUS;

EID: 53849117825     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802426114     Document Type: Article

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