Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2)

European Journal of Pharmaceutical Sciences

Volumn 35, Issue 4, 2008, Pages 326-334

  Yasunaga, Masa ^a,b   Takemura, Masaaki ^b   Fujita, Kyoko ^a   Yabuuchi, Hikaru ^b   Wada, Morimasa ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b GenoMembrane Inc   (Japan)

Author keywords

ABC transporter; ATPase activity; Cynomolgus monkey; Interspecies difference; MRP2

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COMPLEMENTARY DNA; ESTRADIOL; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 2; PROBENECID; VINBLASTINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME SPECIFICITY; LEPIDOPTERA; MOLECULAR CLONING; MONKEY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPECIES DIFFERENCE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOTTING, NORTHERN; CELL LINE; CELL MEMBRANE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INDICATORS AND REAGENTS; KINETICS; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 53849096672     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.08.001     Document Type: Article

References (32)

1. Bakos E., Evers R., Sinko E., Varadi A., Borst P., and Sarkadi B. Interaction of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol. Pharmacol. 57 (2000) 760-768
2. Borst P., Evers R., Kool M., and Wijnholds J. The multidrug resistance protein family. Biochim. Biophys. Acta 1461 (1999) 347-357
3. Bryan J., and Aguilar-Bryan L. The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle. Curr. Opin. Cell Biol. 9 (1997) 553-559
4. Buchler M., Konig J., Brom M., Kartenbeck J., Spring H., Horie T., and Keppler D. cDNA cloning of the hepatocyte canalicular isoform of multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271 (1996) 15091-15098
5. Cole S.P., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M., and Deeley R.G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell. Science 258 (1992) 1650-1654
6. Conrad S., Viertelhaus A., Orzechowski A., Hoogstraate J., Gjellan K., Schrenk D., and Kauffmann H.M. Sequencing and tissue distribution of canine MRP2 gene compared with MRP1 and MDR1. Toxicology 156 (2001) 81-91
7. Dean M., Pzhetsky A., and Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11 (2001) 1156-1166
8. Fritz F., Chen J., Hayes P., and Siromak F.M. Molecular cloning of the murine cMOAT ATPase. Biochim. Biophys. Acta 492 (2000) 531-536
9. Hashimoto K., Uchiumi T., Konno T., Ebihara T., Nakamura T., Wada M., Sakisaka S., Maniwa F., Amachi T., Ueda K., and Kuwano M. Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. Hepatology 36 (2002) 1236-1245
10. Higgins C.F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8 (1992) 67-113
11. Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A.L., and Karlsson J. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab. Dispos. 35 (2007) 1333-1340
12. Hopper E., Belinsky M.G., Zeng H., Tosolini A., Esta J.R., and Kruth G.D. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Lett. 162 (2001) 181-191
13. Ishizuka H., Konno K., Naganuma H., Sasahara K., Kawahara Y., Niinuma K., Suzuki H., and Sugiyama Y. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR). J. Pharmacol. Exp. Ther. 280 (1997) 1304-1311
14. Ishizuka H., Konno K., Shiina T., Naganuma H., Nishimura K., Ito K., Suzuki H., and Sugiyama Y. Species differences in the transport activity for organic anions across the bile canalicular membrane. J. Pharmacol. Exp. Ther. 290 (1999) 1324-1330
15. Ito K., Suzuki H., Hirohashi T., Kume K., Shimizu T., and Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 272 (1997) G16-G22
16. Klein I., Sarkadi B., and Varadi A. An inventory of the human ABC proteins. Biochim. Biophys. Acta 1461 (1999) 237-262
17. Konig J., Nies A.T., Cui Y., Leier I., and Keppler D. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta 1461 (1999) 377-394
18. Kool M., van der Linden M., de Haas M., Baas F., and Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res. 59 (1999) 175-182
19. Niinuma K., Kato Y., Suzuki H., Tyson C.A., Weizer V., Dabbs J.E., Froehlich R., Green C.E., and Sugiyama Y. Primary active transport of organic anions on bile canalicular membrane in humans. Am. J. Physiol. 276 (1999) G1153-G1164
20. Ninomiya M., Ito K., and Horie T. Functional analysis of dog multidrug resistance-associated protein 2 (MRP2) in comparison with rat Mrp2. Drug Metab. Dispos. 33 (2005) 225-232
21. Ninomiya M., Ito K., Hiramatsu R., and Horie T. Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2). Drug Metab. Dispos. 34 (2006) 2056-2063
22. Paulusma C.C., Bosma P.J., Zaman G.J., Bakker C.T., Otter M., Scheffer R.J., Borst P., and Oude Elferink R.P. Congenital jaundice in rats with mutation in a multidrug resistance-associated protein gene. Science 271 (1996) 1126-1128
23. Paulusma C.C., and Elferink R.P.J.O. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man. J. Mol. Med. 75 (1997) 420-428
24. Rommens J.M., Iannuzzi M.C., Kerem B., Drumm M.L., Meimer G., Dean M., Rozmahel R., Cole J.L., Kennedy D., Hidaka N., Zsiga M., Buchwald M., Riordan J.R., Tsui L.C., and Collins F.S. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245 (1989) 1059-1065
25. Sarkadi B., Orice E.M., Boucher R.C., Germann U.A., and Scarborough G.A. Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J. Biol. Chem. 267 (1992) 4854-4858
26. Suzuki H., and Sugiyama Y. Excretion of GSSG and glutathione conjugate export pump on human kidney proximal tubules and in renal cell carcinoma. Semin. Liver Dis. 18 (1998) 359-376
27. Shilling A.D., Azam F., Kao J., and Leung L. Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. J. Pharmacol. Toxicol. Methods 53 (2006) 186-197
28. Taniguchi K., Wada M., Kohno K., Nakamura T., Kawakami M., Kagotani K., Okumura K., Akiyama S., and Kuwano M. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 56 (1996) 4124-4129
29. Toh S., Wada M., Uchiumi T., Makino Y., Horie Y., Adachi Y., Sakisaka S., and Kuwano M. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am. J. Hum. Genet. 64 (1999) 739-746
30. van Kuijck M.A., van Aubel R.A., Busch A.E., Lang F., Russel F.G., Bindels R.J., van Os C.H., and Deen P.M. Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 5401-5406
31. Wada M., Toh S., Taniguchi K., Nakayama T., Uchiumi T., Kohno K., Yoshida I., Kimura A., Sakisaka S., Adachi Y., and Kuwano M. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum. Mol. Genet. 7 (1998) 203-207
32. Yabuuchi H., Shimizu H., Takayanagi S., and Ishikawa T. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. Biochem. Biophys. Res. Commun. 288 (2001) 933-939