메뉴 건너뛰기




Volumn 25, Issue 4, 2008, Pages 304-316

Targeting sarcomas: therapeutic targets and their rational

Author keywords

Cancer stem cells; Drug; Ewing's sarcoma; Sarcomas; Targeted therapy

Indexed keywords

ANTHRACYCLINE; AP 23573; BEVACIZUMAB; BORTEZOMIB; CEDIRANIB; CETUXIMAB; CP 751871; DACARBAZINE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GEFITINIB; GEMCITABINE; HEAT SHOCK PROTEIN 90; IFOSFAMIDE; IMATINIB; IXABEPILONE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; PACLITAXEL; RAPAMYCIN; SEMAXANIB; SOMATOMEDIN C RECEPTOR; STA 4783; STEM CELL FACTOR RECEPTOR; TANESPIMYCIN; TAXANE DERIVATIVE; TEMSIROLIMUS; TOPOTECAN; TRABECTEDIN; TRASTUZUMAB; TYROSINE KINASE RECEPTOR; U 6668; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR;

EID: 53749094926     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2008.07.005     Document Type: Article
Times cited : (12)

References (133)
  • 1
    • 34249723214 scopus 로고    scopus 로고
    • Opportunities for improving the therapeutic ratio for patients with sarcoma
    • Wunder J.S., Nielsen T.O., Maki R.G., et al. Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol 8 (2007) 513-524
    • (2007) Lancet Oncol , vol.8 , pp. 513-524
    • Wunder, J.S.1    Nielsen, T.O.2    Maki, R.G.3
  • 2
    • 47249110359 scopus 로고    scopus 로고
    • New targets for therapy of sarcoma
    • Magenau J.M., and Schuetze S.M. New targets for therapy of sarcoma. Curr Opin Oncol 20 (2008) 400-406
    • (2008) Curr Opin Oncol , vol.20 , pp. 400-406
    • Magenau, J.M.1    Schuetze, S.M.2
  • 3
    • 33846705266 scopus 로고    scopus 로고
    • Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines
    • Hartmann J.T. Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines. Anticancer Drugs 18 (2007) 245-254
    • (2007) Anticancer Drugs , vol.18 , pp. 245-254
    • Hartmann, J.T.1
  • 5
    • 45149090773 scopus 로고    scopus 로고
    • Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Casali P.G., Jost L., Sleijfer S., et al. Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 19 suppl 2 (2008) ii89-ii93
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 2
    • Casali, P.G.1    Jost, L.2    Sleijfer, S.3
  • 6
    • 34447572873 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected]
    • Maki R.G., Wathen J.K., Patel S.R., et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected]. J Clin Oncol 25 (2007) 2755-2763
    • (2007) J Clin Oncol , vol.25 , pp. 2755-2763
    • Maki, R.G.1    Wathen, J.K.2    Patel, S.R.3
  • 7
    • 46749092063 scopus 로고    scopus 로고
    • Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma
    • Schoffski P., Dumez H., Wolter P., et al. Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma. Expert Opin Pharmacother 9 (2008) 1609-1618
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1609-1618
    • Schoffski, P.1    Dumez, H.2    Wolter, P.3
  • 8
    • 33748314666 scopus 로고    scopus 로고
    • Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET-743, NSC 684766
    • Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET-743, NSC 684766. Drugs R D 7 (2006) 317-328
    • (2006) Drugs R D , vol.7 , pp. 317-328
  • 9
    • 2342461682 scopus 로고    scopus 로고
    • Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
    • Garcia-Carbonero R., Supko J.G., Manola J., et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol 22 (2004) 1480-1490
    • (2004) J Clin Oncol , vol.22 , pp. 1480-1490
    • Garcia-Carbonero, R.1    Supko, J.G.2    Manola, J.3
  • 10
    • 34547867058 scopus 로고    scopus 로고
    • Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma
    • Schoffski P., Wolter P., Clement P., et al. Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma. Future Oncol 3 (2007) 381-392
    • (2007) Future Oncol , vol.3 , pp. 381-392
    • Schoffski, P.1    Wolter, P.2    Clement, P.3
  • 11
    • 34347214071 scopus 로고    scopus 로고
    • Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study
    • Grosso F., Jones R.L., Demetri G.D., et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol 8 (2007) 595-602
    • (2007) Lancet Oncol , vol.8 , pp. 595-602
    • Grosso, F.1    Jones, R.L.2    Demetri, G.D.3
  • 12
    • 47249106539 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor 1 receptor in sarcomas
    • Scotlandi K., and Picci P. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr Opin Oncol 20 (2008) 419-427
    • (2008) Curr Opin Oncol , vol.20 , pp. 419-427
    • Scotlandi, K.1    Picci, P.2
  • 13
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins A.S., Mackintosh C., Martin D.H., et al. Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 12 (2006) 3532-3540
    • (2006) Clin Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    Mackintosh, C.2    Martin, D.H.3
  • 14
    • 23644446486 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor as a target for cancer therapy
    • Baserga R. The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets 9 (2005) 753-768
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 753-768
    • Baserga, R.1
  • 15
    • 0036782071 scopus 로고    scopus 로고
    • Structural biology of insulin and IGF1 receptors: implications for drug design
    • De Meyts P., and Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 1 (2002) 769-783
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 769-783
    • De Meyts, P.1    Whittaker, J.2
  • 16
    • 34548078061 scopus 로고    scopus 로고
    • Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma
    • Savage S.A., Woodson K., Walk E., et al. Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. Cancer Epidemiol Biomarkers Prev 16 (2007) 1667-1674
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 1667-1674
    • Savage, S.A.1    Woodson, K.2    Walk, E.3
  • 17
    • 39549120036 scopus 로고    scopus 로고
    • Monoclonal antibodies against components of the IGF system for cancer treatment
    • Feng Y., and Dimitrov D.S. Monoclonal antibodies against components of the IGF system for cancer treatment. Curr Opin Drug Discov Dev 11 (2008) 178-185
    • (2008) Curr Opin Drug Discov Dev , vol.11 , pp. 178-185
    • Feng, Y.1    Dimitrov, D.S.2
  • 18
    • 33847348574 scopus 로고    scopus 로고
    • Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas
    • Do I., Araujo E.S., Kalil R.K., et al. Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas. Pathol Res Pract 203 (2007) 127-134
    • (2007) Pathol Res Pract , vol.203 , pp. 127-134
    • Do, I.1    Araujo, E.S.2    Kalil, R.K.3
  • 19
    • 10744222923 scopus 로고    scopus 로고
    • Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis
    • Gonzalez I., Andreu E.J., Panizo A., et al. Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis. Clin Cancer Res 10 (2004) 751-761
    • (2004) Clin Cancer Res , vol.10 , pp. 751-761
    • Gonzalez, I.1    Andreu, E.J.2    Panizo, A.3
  • 20
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study
    • Bond M., Bernstein M.L., Pappo A., et al. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer 50 (2008) 254-258
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 254-258
    • Bond, M.1    Bernstein, M.L.2    Pappo, A.3
  • 21
    • 14144256775 scopus 로고    scopus 로고
    • Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225
    • McArthur G.A., Demetri G.D., van Oosterom A., et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. J Clin Oncol 23 (2005) 866-873
    • (2005) J Clin Oncol , vol.23 , pp. 866-873
    • McArthur, G.A.1    Demetri, G.D.2    van Oosterom, A.3
  • 23
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo D.R., Anderson S.E., Albritton K., et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol 23 (2005) 7135-7142
    • (2005) J Clin Oncol , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 24
    • 4444250452 scopus 로고    scopus 로고
    • Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    • Heymach J.V., Desai J., Manola J., et al. Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. Clin Cancer Res 10 (2004) 5732-5740
    • (2004) Clin Cancer Res , vol.10 , pp. 5732-5740
    • Heymach, J.V.1    Desai, J.2    Manola, J.3
  • 25
    • 46149092748 scopus 로고    scopus 로고
    • Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
    • (in press)
    • Jiang B.H., and Liu L.Z. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat (2008) (in press)
    • (2008) Drug Resist Updat
    • Jiang, B.H.1    Liu, L.Z.2
  • 26
    • 34548427415 scopus 로고    scopus 로고
    • The biology behind mTOR inhibition in sarcoma
    • Wan X., and Helman L.J. The biology behind mTOR inhibition in sarcoma. Oncologist 12 (2007) 1007-1018
    • (2007) Oncologist , vol.12 , pp. 1007-1018
    • Wan, X.1    Helman, L.J.2
  • 27
    • 39049091952 scopus 로고    scopus 로고
    • Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells
    • Vojtechova M., Tureckova J., Kucerova D., et al. Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells. Neoplasia 10 (2008) 99-107
    • (2008) Neoplasia , vol.10 , pp. 99-107
    • Vojtechova, M.1    Tureckova, J.2    Kucerova, D.3
  • 28
    • 0037070754 scopus 로고    scopus 로고
    • Molecular characterisation of soft tissue tumours: a gene expression study
    • Nielsen T.O., West R.B., Linn S.C., et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet 359 (2002) 1301-1307
    • (2002) Lancet , vol.359 , pp. 1301-1307
    • Nielsen, T.O.1    West, R.B.2    Linn, S.C.3
  • 30
    • 0141648453 scopus 로고    scopus 로고
    • Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology
    • Nielsen T.O., Hsu F.D., O'Connell J.X., et al. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am J Pathol 163 (2003) 1449-1456
    • (2003) Am J Pathol , vol.163 , pp. 1449-1456
    • Nielsen, T.O.1    Hsu, F.D.2    O'Connell, J.X.3
  • 31
    • 33745134735 scopus 로고    scopus 로고
    • Drug evaluation: STA-4783-enhancing taxane efficacy by induction of Hsp70
    • Gehrmann M. Drug evaluation: STA-4783-enhancing taxane efficacy by induction of Hsp70. Curr Opin Invest Drugs 7 (2006) 574-580
    • (2006) Curr Opin Invest Drugs , vol.7 , pp. 574-580
    • Gehrmann, M.1
  • 32
    • 33846856501 scopus 로고    scopus 로고
    • Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
    • Berkenblit A., Eder Jr. J.P., Ryan D.P., et al. Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors. Clin Cancer Res 13 (2007) 584-590
    • (2007) Clin Cancer Res , vol.13 , pp. 584-590
    • Berkenblit, A.1    Eder Jr., J.P.2    Ryan, D.P.3
  • 33
    • 27644481943 scopus 로고    scopus 로고
    • Thrombospondin 1, thrombospondin 2 and the eye
    • Hiscott P., Paraoan L., Choudhary A., et al. Thrombospondin 1, thrombospondin 2 and the eye. Prog Retin Eye Res 25 (2006) 1-18
    • (2006) Prog Retin Eye Res , vol.25 , pp. 1-18
    • Hiscott, P.1    Paraoan, L.2    Choudhary, A.3
  • 34
    • 33646967516 scopus 로고    scopus 로고
    • Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma
    • Ordonez J.L., Paraoan L., Hiscott P., et al. Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. Melanoma Res 15 (2005) 495-502
    • (2005) Melanoma Res , vol.15 , pp. 495-502
    • Ordonez, J.L.1    Paraoan, L.2    Hiscott, P.3
  • 35
    • 45949093196 scopus 로고    scopus 로고
    • Potential combination chemotherapy approaches for advanced adult-type soft-tissue sarcoma
    • Kopp H.G., Patel S., Brucher B., et al. Potential combination chemotherapy approaches for advanced adult-type soft-tissue sarcoma. Am J Clin Dermatol 9 (2008) 207-217
    • (2008) Am J Clin Dermatol , vol.9 , pp. 207-217
    • Kopp, H.G.1    Patel, S.2    Brucher, B.3
  • 36
    • 33846228382 scopus 로고    scopus 로고
    • Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics. ABT-526 and ABT-510, in companion dogs with naturally occurring cancers
    • Rusk A., McKeegan E., Haviv F., et al. Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics. ABT-526 and ABT-510, in companion dogs with naturally occurring cancers. Clin Cancer Res 12 (2006) 7444-7455
    • (2006) Clin Cancer Res , vol.12 , pp. 7444-7455
    • Rusk, A.1    McKeegan, E.2    Haviv, F.3
  • 37
    • 41849086234 scopus 로고    scopus 로고
    • Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma
    • Bersani F., Taulli R., Accornero P., et al. Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma. Eur J Cancer 44 (2008) 876-884
    • (2008) Eur J Cancer , vol.44 , pp. 876-884
    • Bersani, F.1    Taulli, R.2    Accornero, P.3
  • 38
    • 45349092269 scopus 로고    scopus 로고
    • Proteasome inhibitor Bortezomib induces cell-cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL
    • Lu G., Punj V., and Chaudhary P.M. Proteasome inhibitor Bortezomib induces cell-cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL. Cancer Biol Ther 7 (2008) 603-608
    • (2008) Cancer Biol Ther , vol.7 , pp. 603-608
    • Lu, G.1    Punj, V.2    Chaudhary, P.M.3
  • 39
    • 15744364211 scopus 로고    scopus 로고
    • A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas
    • Maki R.G., Kraft A.S., Scheu K., et al. A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas. Cancer 103 (2005) 1431-1438
    • (2005) Cancer , vol.103 , pp. 1431-1438
    • Maki, R.G.1    Kraft, A.S.2    Scheu, K.3
  • 40
    • 35848931009 scopus 로고    scopus 로고
    • The mechanism of cross-resistance to proteasome inhibitor bortezomib and overcoming resistance in Ewing's family tumor cells
    • Nakamura T., Tanaka K., Matsunobu T., et al. The mechanism of cross-resistance to proteasome inhibitor bortezomib and overcoming resistance in Ewing's family tumor cells. Int J Oncol 31 (2007) 803-811
    • (2007) Int J Oncol , vol.31 , pp. 803-811
    • Nakamura, T.1    Tanaka, K.2    Matsunobu, T.3
  • 41
    • 0028209984 scopus 로고
    • DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
    • Bailly R.A., Bosselut R., Zucman J., et al. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 14 (1994) 3230-3241
    • (1994) Mol Cell Biol , vol.14 , pp. 3230-3241
    • Bailly, R.A.1    Bosselut, R.2    Zucman, J.3
  • 42
    • 0027230568 scopus 로고
    • Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
    • May W.A., Gishizky M.L., Lessnick S.L., et al. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A 90 (1993) 5752-5756
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3
  • 43
    • 0027362619 scopus 로고
    • The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
    • May W.A., Lessnick S.L., Braun B.S., et al. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 13 (1993) 7393-7398
    • (1993) Mol Cell Biol , vol.13 , pp. 7393-7398
    • May, W.A.1    Lessnick, S.L.2    Braun, B.S.3
  • 44
    • 0027932782 scopus 로고
    • The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts
    • Delattre O., Zucman J., Melot T., et al. The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 331 (1994) 294-299
    • (1994) N Engl J Med , vol.331 , pp. 294-299
    • Delattre, O.1    Zucman, J.2    Melot, T.3
  • 45
    • 0031924824 scopus 로고    scopus 로고
    • EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma
    • de Alava E., Kawai A., Healey J.H., et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 16 (1998) 1248-1255
    • (1998) J Clin Oncol , vol.16 , pp. 1248-1255
    • de Alava, E.1    Kawai, A.2    Healey, J.H.3
  • 46
    • 9244236526 scopus 로고    scopus 로고
    • Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?
    • Zoubek A., Dockhorn-Dworniczak B., Delattre O., et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?. J Clin Oncol 14 (1996) 1245-1251
    • (1996) J Clin Oncol , vol.14 , pp. 1245-1251
    • Zoubek, A.1    Dockhorn-Dworniczak, B.2    Delattre, O.3
  • 47
    • 44349145643 scopus 로고    scopus 로고
    • The EWS/FLI1 oncogenic transcription factor deregulates GLI1
    • Zwerner J.P., Joo J., Warner K.L., et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 27 (2008) 3282-3291
    • (2008) Oncogene , vol.27 , pp. 3282-3291
    • Zwerner, J.P.1    Joo, J.2    Warner, K.L.3
  • 48
    • 1242293672 scopus 로고    scopus 로고
    • The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors
    • Rorie C.J., Thomas V.D., Chen P., et al. The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res 64 (2004) 1266-1277
    • (2004) Cancer Res , vol.64 , pp. 1266-1277
    • Rorie, C.J.1    Thomas, V.D.2    Chen, P.3
  • 49
    • 0035242001 scopus 로고    scopus 로고
    • PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors
    • Zwerner J.P., and May W.A. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. Oncogene 20 (2001) 626-633
    • (2001) Oncogene , vol.20 , pp. 626-633
    • Zwerner, J.P.1    May, W.A.2
  • 50
    • 0035937366 scopus 로고    scopus 로고
    • Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genes
    • Matsumoto Y., Tanaka K., Nakatani F., et al. Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genes. Br J Cancer 84 (2001) 768-775
    • (2001) Br J Cancer , vol.84 , pp. 768-775
    • Matsumoto, Y.1    Tanaka, K.2    Nakatani, F.3
  • 51
    • 0034968428 scopus 로고    scopus 로고
    • Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression
    • Dauphinot L., De Oliveira C., Melot T., et al. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. Oncogene 20 (2001) 3258-3265
    • (2001) Oncogene , vol.20 , pp. 3258-3265
    • Dauphinot, L.1    De Oliveira, C.2    Melot, T.3
  • 52
    • 0032848660 scopus 로고    scopus 로고
    • Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein
    • Hahm K.B., Cho K., Lee C., et al. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet 23 (1999) 222-227
    • (1999) Nat Genet , vol.23 , pp. 222-227
    • Hahm, K.B.1    Cho, K.2    Lee, C.3
  • 53
    • 0342424350 scopus 로고    scopus 로고
    • EWS-FLI1. EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene
    • Im Y.H., Kim H.T., Lee C., et al. EWS-FLI1. EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene. Cancer Res 60 (2000) 1536-1540
    • (2000) Cancer Res , vol.60 , pp. 1536-1540
    • Im, Y.H.1    Kim, H.T.2    Lee, C.3
  • 54
    • 0038689323 scopus 로고    scopus 로고
    • Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein
    • Nakatani F., Tanaka K., Sakimura R., et al. Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein. J Biol Chem 278 (2003) 15105-15115
    • (2003) J Biol Chem , vol.278 , pp. 15105-15115
    • Nakatani, F.1    Tanaka, K.2    Sakimura, R.3
  • 55
    • 0037427070 scopus 로고    scopus 로고
    • Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma
    • Fukuma M., Okita H., Hata J., et al. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene 22 (2003) 1-9
    • (2003) Oncogene , vol.22 , pp. 1-9
    • Fukuma, M.1    Okita, H.2    Hata, J.3
  • 56
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A., Tirode F., Cohen P., et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 24 (2004) 7275-7283
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3
  • 57
    • 33644537353 scopus 로고    scopus 로고
    • The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors
    • Mendiola M., Carrillo J., Garcia E., et al. The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors. Int J Cancer 118 (2006) 1381-1389
    • (2006) Int J Cancer , vol.118 , pp. 1381-1389
    • Mendiola, M.1    Carrillo, J.2    Garcia, E.3
  • 58
    • 0031040025 scopus 로고    scopus 로고
    • Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides
    • Toretsky J.A., Connell Y., Neckers L., et al. Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides. J Neurooncol 31 (1997) 9-16
    • (1997) J Neurooncol , vol.31 , pp. 9-16
    • Toretsky, J.A.1    Connell, Y.2    Neckers, L.3
  • 59
    • 0031025207 scopus 로고    scopus 로고
    • EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells
    • Tanaka K., Iwakuma T., Harimaya K., et al. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 99 (1997) 239-247
    • (1997) J Clin Invest , vol.99 , pp. 239-247
    • Tanaka, K.1    Iwakuma, T.2    Harimaya, K.3
  • 60
    • 41149109010 scopus 로고    scopus 로고
    • Treatment of Ewing's sarcoma using an antisense oligodeoxynucleotide to regulate the cell cycle
    • Asami S., Chin M., Shichino H., et al. Treatment of Ewing's sarcoma using an antisense oligodeoxynucleotide to regulate the cell cycle. Biol Pharm Bull 31 (2008) 391-394
    • (2008) Biol Pharm Bull , vol.31 , pp. 391-394
    • Asami, S.1    Chin, M.2    Shichino, H.3
  • 61
    • 0029829794 scopus 로고    scopus 로고
    • EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro
    • Kovar H., Aryee D.N., Jug G., et al. EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro. Cell Growth Differ 7 (1996) 429-437
    • (1996) Cell Growth Differ , vol.7 , pp. 429-437
    • Kovar, H.1    Aryee, D.N.2    Jug, G.3
  • 62
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S., Heidel J.D., Bartlett D.W., et al. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65 (2005) 8984-8992
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3
  • 63
    • 34247098863 scopus 로고    scopus 로고
    • Evidence for activation of KIT. PDGFRalpha, and PDGFRbeta receptors in the Ewing sarcoma family of tumors
    • Bozzi F., Tamborini E., Negri T., et al. Evidence for activation of KIT. PDGFRalpha, and PDGFRbeta receptors in the Ewing sarcoma family of tumors. Cancer 109 (2007) 1638-1645
    • (2007) Cancer , vol.109 , pp. 1638-1645
    • Bozzi, F.1    Tamborini, E.2    Negri, T.3
  • 64
    • 34247877772 scopus 로고    scopus 로고
    • Cholecystokinin down-regulation by RNA interference impairs Ewing tumor growth
    • Carrillo J., Garcia-Aragoncillo E., Azorin D., et al. Cholecystokinin down-regulation by RNA interference impairs Ewing tumor growth. Clin Cancer Res 13 (2007) 2429-2440
    • (2007) Clin Cancer Res , vol.13 , pp. 2429-2440
    • Carrillo, J.1    Garcia-Aragoncillo, E.2    Azorin, D.3
  • 65
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins. Getting in on the Akt
    • Brazil D.P., Park J., and Hemmings B.A. PKB binding proteins. Getting in on the Akt. Cell 111 (2002) 293-303
    • (2002) Cell , vol.111 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 66
    • 0035990924 scopus 로고    scopus 로고
    • Inhibition of protein kinase B/Akt implications for cancer therapy
    • Hill M.M., and Hemmings B.A. Inhibition of protein kinase B/Akt implications for cancer therapy. Pharmacol Ther 93 (2002) 243-251
    • (2002) Pharmacol Ther , vol.93 , pp. 243-251
    • Hill, M.M.1    Hemmings, B.A.2
  • 67
    • 0034797303 scopus 로고    scopus 로고
    • Analysis of protein kinase B/Akt
    • Hill M.M., and Hemmings B.A. Analysis of protein kinase B/Akt. Methods Enzymol 345 (2002) 448-463
    • (2002) Methods Enzymol , vol.345 , pp. 448-463
    • Hill, M.M.1    Hemmings, B.A.2
  • 68
    • 0032827420 scopus 로고    scopus 로고
    • Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
    • Peruzzi F., Prisco M., Dews M., et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 19 (1999) 7203-7215
    • (1999) Mol Cell Biol , vol.19 , pp. 7203-7215
    • Peruzzi, F.1    Prisco, M.2    Dews, M.3
  • 69
    • 0347626094 scopus 로고    scopus 로고
    • Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects
    • Benini S., Manara M.C., Cerisano V., et al. Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects. Int J Cancer 108 (2004) 358-366
    • (2004) Int J Cancer , vol.108 , pp. 358-366
    • Benini, S.1    Manara, M.C.2    Cerisano, V.3
  • 70
    • 7944223834 scopus 로고    scopus 로고
    • Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
    • Chan S. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer 91 (2004) 1420-1424
    • (2004) Br J Cancer , vol.91 , pp. 1420-1424
    • Chan, S.1
  • 71
    • 33746590349 scopus 로고    scopus 로고
    • Clinical significance of vascular endothelial growth factor-A expression in Ewing's sarcoma
    • Kreuter M., Paulussen M., Boeckeler J., et al. Clinical significance of vascular endothelial growth factor-A expression in Ewing's sarcoma. Eur J Cancer 42 (2006) 1904-1911
    • (2006) Eur J Cancer , vol.42 , pp. 1904-1911
    • Kreuter, M.1    Paulussen, M.2    Boeckeler, J.3
  • 72
    • 17644403503 scopus 로고    scopus 로고
    • A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
    • Guan H., Zhou Z., Wang H., et al. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 11 (2005) 2662-2669
    • (2005) Clin Cancer Res , vol.11 , pp. 2662-2669
    • Guan, H.1    Zhou, Z.2    Wang, H.3
  • 73
    • 16844366948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family
    • Dalal S., Berry A.M., Cullinane C.J., et al. Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family. Clin Cancer Res 11 (2005) 2364-2378
    • (2005) Clin Cancer Res , vol.11 , pp. 2364-2378
    • Dalal, S.1    Berry, A.M.2    Cullinane, C.J.3
  • 74
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A., Gray A., Tam A.W., et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5 (1986) 2503-2512
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3
  • 75
    • 0028024151 scopus 로고
    • cDNA cloning of the rat IGF I receptors: structural analysis of rat and human IGF I and insulin receptors reveals differences in alternative splicing and receptor-specific domain conservation
    • Pedrini M.T., Giorgino F., and Smith R.J. cDNA cloning of the rat IGF I receptors: structural analysis of rat and human IGF I and insulin receptors reveals differences in alternative splicing and receptor-specific domain conservation. Biochem Biophys Res Commun 202 (1994) 1038-1046
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 1038-1046
    • Pedrini, M.T.1    Giorgino, F.2    Smith, R.J.3
  • 76
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target
    • Scotlandi K., Benini S., Sarti M., et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Res 56 (1996) 4570-4574
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3
  • 77
    • 1642540093 scopus 로고    scopus 로고
    • Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation
    • Mateo-Lozano S., Tirado O.M., and Notario V. Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 22 (2003) 9282-9287
    • (2003) Oncogene , vol.22 , pp. 9282-9287
    • Mateo-Lozano, S.1    Tirado, O.M.2    Notario, V.3
  • 78
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    • Mitsiades C.S., Mitsiades N.S., McMullan C.J., et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5 (2004) 221-230
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 79
    • 0346095216 scopus 로고    scopus 로고
    • Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewing's sarcoma cells
    • Strammiello R., Benini S., Manara M.C., et al. Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewing's sarcoma cells. Horm Metab Res 35 (2003) 675-684
    • (2003) Horm Metab Res , vol.35 , pp. 675-684
    • Strammiello, R.1    Benini, S.2    Manara, M.C.3
  • 80
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
    • Garcia-Echeverria C., Pearson M.A., Marti A., et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5 (2004) 231-239
    • (2004) Cancer Cell , vol.5 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3
  • 81
    • 20944447905 scopus 로고    scopus 로고
    • Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
    • Scotlandi K., Manara M.C., Nicoletti G., et al. Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res 65 (2005) 3868-3876
    • (2005) Cancer Res , vol.65 , pp. 3868-3876
    • Scotlandi, K.1    Manara, M.C.2    Nicoletti, G.3
  • 82
    • 14644433735 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor kinase inhibitor. NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
    • Warshamana-Greene G.S., Litz J., Buchdunger E., et al. The insulin-like growth factor-I receptor kinase inhibitor. NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 11 (2005) 1563-1571
    • (2005) Clin Cancer Res , vol.11 , pp. 1563-1571
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3
  • 83
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • Toretsky J.A., Kalebic T., Blakesley V., et al. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem 272 (1997) 30822-30827
    • (1997) J Biol Chem , vol.272 , pp. 30822-30827
    • Toretsky, J.A.1    Kalebic, T.2    Blakesley, V.3
  • 84
    • 4444282902 scopus 로고    scopus 로고
    • The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling
    • Warshamana-Greene G.S., Litz J., Buchdunger E., et al. The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol Cancer Ther 3 (2004) 527-535
    • (2004) Mol Cancer Ther , vol.3 , pp. 527-535
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3
  • 85
    • 2642518825 scopus 로고    scopus 로고
    • Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells
    • Camirand A., and Pollak M. Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br J Cancer 90 (2004) 1825-1829
    • (2004) Br J Cancer , vol.90 , pp. 1825-1829
    • Camirand, A.1    Pollak, M.2
  • 86
    • 49249125421 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor Type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma
    • Lacy M.Q., Alsina M., Fonseca R., et al. Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor Type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma. J Clin Oncol 26 (2008) 3196-3203
    • (2008) J Clin Oncol , vol.26 , pp. 3196-3203
    • Lacy, M.Q.1    Alsina, M.2    Fonseca, R.3
  • 87
    • 47249160783 scopus 로고    scopus 로고
    • Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future
    • Ludwig J.A. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 20 (2008) 412-418
    • (2008) Curr Opin Oncol , vol.20 , pp. 412-418
    • Ludwig, J.A.1
  • 88
    • 0025915426 scopus 로고
    • Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2
    • Fellinger E.J., Garin-Chesa P., Triche T.J., et al. Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2. Am J Pathol 139 (1991) 317-325
    • (1991) Am J Pathol , vol.139 , pp. 317-325
    • Fellinger, E.J.1    Garin-Chesa, P.2    Triche, T.J.3
  • 89
    • 0028215153 scopus 로고
    • Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma
    • Weidner N., and Tjoe J. Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol 18 (1994) 486-494
    • (1994) Am J Surg Pathol , vol.18 , pp. 486-494
    • Weidner, N.1    Tjoe, J.2
  • 90
    • 0034665335 scopus 로고    scopus 로고
    • CD99 engagement: an effective therapeutic strategy for Ewing tumors
    • Scotlandi K., Baldini N., Cerisano V., et al. CD99 engagement: an effective therapeutic strategy for Ewing tumors. Cancer Res 60 (2000) 5134-5142
    • (2000) Cancer Res , vol.60 , pp. 5134-5142
    • Scotlandi, K.1    Baldini, N.2    Cerisano, V.3
  • 91
    • 29144462140 scopus 로고    scopus 로고
    • Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma
    • Scotlandi K., Perdichizzi S., Bernard G., et al. Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma. Eur J Cancer 42 (2006) 91-96
    • (2006) Eur J Cancer , vol.42 , pp. 91-96
    • Scotlandi, K.1    Perdichizzi, S.2    Bernard, G.3
  • 92
    • 3343024743 scopus 로고    scopus 로고
    • Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators
    • Cerisano V., Aalto Y., Perdichizzi S., et al. Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators. Oncogene 23 (2004) 5664-5674
    • (2004) Oncogene , vol.23 , pp. 5664-5674
    • Cerisano, V.1    Aalto, Y.2    Perdichizzi, S.3
  • 93
    • 0032924953 scopus 로고    scopus 로고
    • Hsp90 & Co. - a holding for folding
    • Buchner J. Hsp90 & Co. - a holding for folding. Trends Biochem Sci 24 (1999) 136-141
    • (1999) Trends Biochem Sci , vol.24 , pp. 136-141
    • Buchner, J.1
  • 94
    • 0031018610 scopus 로고    scopus 로고
    • Heat shock response-pathophysiological implications
    • Leppa S., and Sistonen L. Heat shock response-pathophysiological implications. Ann Med 29 (1997) 73-78
    • (1997) Ann Med , vol.29 , pp. 73-78
    • Leppa, S.1    Sistonen, L.2
  • 95
    • 4344674482 scopus 로고    scopus 로고
    • Targeting multiple signal transduction pathways through inhibition of Hsp90
    • Zhang H., and Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med 82 (2004) 488-499
    • (2004) J Mol Med , vol.82 , pp. 488-499
    • Zhang, H.1    Burrows, F.2
  • 96
    • 22144458740 scopus 로고    scopus 로고
    • Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia
    • Thomas X., Campos L., Mounier C., et al. Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia. Leuk Res 29 (2005) 1049-1058
    • (2005) Leuk Res , vol.29 , pp. 1049-1058
    • Thomas, X.1    Campos, L.2    Mounier, C.3
  • 97
    • 0038404927 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
    • Solit D.B., Basso A.D., Olshen A.B., et al. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 63 (2003) 2139-2144
    • (2003) Cancer Res , vol.63 , pp. 2139-2144
    • Solit, D.B.1    Basso, A.D.2    Olshen, A.B.3
  • 98
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L., and Lindquist S.L. HSP90 and the chaperoning of cancer. Nat Rev Cancer 5 (2005) 761-772
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 100
    • 51049098720 scopus 로고    scopus 로고
    • A pivotal role for heat shock protein 90 in Ewing Sarcoma resistance to anti-IGF1R treatment: in vitro and in vivo study
    • Martins A.S., Ordoñez J.L., García-Sánchez A., et al. A pivotal role for heat shock protein 90 in Ewing Sarcoma resistance to anti-IGF1R treatment: in vitro and in vivo study. Cancer Res 68 (2008) 6260-6270
    • (2008) Cancer Res , vol.68 , pp. 6260-6270
    • Martins, A.S.1    Ordoñez, J.L.2    García-Sánchez, A.3
  • 101
    • 34250162501 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study
    • Bagatell R., Gore L., Egorin M.J., et al. Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study. Clin Cancer Res 13 (2007) 1783-1788
    • (2007) Clin Cancer Res , vol.13 , pp. 1783-1788
    • Bagatell, R.1    Gore, L.2    Egorin, M.J.3
  • 102
    • 34250182069 scopus 로고    scopus 로고
    • A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study
    • Weigel B.J., Blaney S.M., Reid J.M., et al. A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study. Clin Cancer Res 13 (2007) 1789-1793
    • (2007) Clin Cancer Res , vol.13 , pp. 1789-1793
    • Weigel, B.J.1    Blaney, S.M.2    Reid, J.M.3
  • 103
    • 50349093362 scopus 로고    scopus 로고
    • A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with Paclitaxel in patients with advanced solid malignancies
    • Ramalingam S.S., Egorin M.J., Ramanathan R.K., et al. A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with Paclitaxel in patients with advanced solid malignancies. Clin Cancer Res 14 (2008) 3456-3461
    • (2008) Clin Cancer Res , vol.14 , pp. 3456-3461
    • Ramalingam, S.S.1    Egorin, M.J.2    Ramanathan, R.K.3
  • 104
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG. KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study
    • Modi S., Stopeck A.T., Gordon M.S., et al. Combination of trastuzumab and tanespimycin (17-AAG. KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 25 (2007) 5410-5417
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3
  • 105
    • 27144523169 scopus 로고    scopus 로고
    • Gene expression profiling of human sarcomas: insights into sarcoma biology
    • Baird K., Davis S., Antonescu C.R., et al. Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res 65 (2005) 9226-9235
    • (2005) Cancer Res , vol.65 , pp. 9226-9235
    • Baird, K.1    Davis, S.2    Antonescu, C.R.3
  • 106
    • 25444507396 scopus 로고    scopus 로고
    • Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors
    • Castillero-Trejo Y., Eliazer S., Xiang L., et al. Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors. Cancer Res 65 (2005) 8698-8705
    • (2005) Cancer Res , vol.65 , pp. 8698-8705
    • Castillero-Trejo, Y.1    Eliazer, S.2    Xiang, L.3
  • 107
    • 29244447707 scopus 로고    scopus 로고
    • Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells
    • Riggi N., Cironi L., Provero P., et al. Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res 65 (2005) 11459-11468
    • (2005) Cancer Res , vol.65 , pp. 11459-11468
    • Riggi, N.1    Cironi, L.2    Provero, P.3
  • 108
    • 33746924453 scopus 로고    scopus 로고
    • Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    • Riggi N., Cironi L., Provero P., et al. Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res 66 (2006) 7016-7023
    • (2006) Cancer Res , vol.66 , pp. 7016-7023
    • Riggi, N.1    Cironi, L.2    Provero, P.3
  • 109
    • 42049089299 scopus 로고    scopus 로고
    • EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
    • Riggi N., Suva M.L., Suva D., et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 68 (2008) 2176-2185
    • (2008) Cancer Res , vol.68 , pp. 2176-2185
    • Riggi, N.1    Suva, M.L.2    Suva, D.3
  • 110
    • 34547509586 scopus 로고    scopus 로고
    • Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
    • Funes J.M., Quintero M., Henderson S., et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A 104 (2007) 6223-6228
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6223-6228
    • Funes, J.M.1    Quintero, M.2    Henderson, S.3
  • 111
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • Schatton T., Murphy G.F., Frank N.Y., et al. Identification of cells initiating human melanomas. Nature 451 (2008) 345-349
    • (2008) Nature , vol.451 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 112
    • 3242816121 scopus 로고    scopus 로고
    • Clinical resistance to imatinib: mechanisms and implications
    • Hochhaus A., and Hughes T. Clinical resistance to imatinib: mechanisms and implications. Hematol Oncol Clin North Am 18 (2004) 641-656
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 641-656
    • Hochhaus, A.1    Hughes, T.2
  • 113
    • 36849001255 scopus 로고    scopus 로고
    • Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines
    • Komuro H., Saihara R., Shinya M., et al. Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. J Pediatr Surg 42 (2007) 2040-2045
    • (2007) J Pediatr Surg , vol.42 , pp. 2040-2045
    • Komuro, H.1    Saihara, R.2    Shinya, M.3
  • 114
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R., Holtz M., Niu N., et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101 (2003) 4701-4707
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 115
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: stem cells in cancer
    • Polyak K., and Hahn W.C. Roots and stems: stem cells in cancer. Nat Med 12 (2006) 296-300
    • (2006) Nat Med , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 116
    • 36049042525 scopus 로고    scopus 로고
    • Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
    • Matushansky I., Hernando E., Socci N.D., et al. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest 117 (2007) 3248-3257
    • (2007) J Clin Invest , vol.117 , pp. 3248-3257
    • Matushansky, I.1    Hernando, E.2    Socci, N.D.3
  • 117
    • 35848945105 scopus 로고    scopus 로고
    • Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients
    • Taubert H., Wurl P., Greither T., et al. Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients. Oncogene 26 (2007) 7170-7174
    • (2007) Oncogene , vol.26 , pp. 7170-7174
    • Taubert, H.1    Wurl, P.2    Greither, T.3
  • 118
    • 33845981049 scopus 로고    scopus 로고
    • Successful therapy must eradicate cancer stem cells
    • Dingli D., and Michor F. Successful therapy must eradicate cancer stem cells. Stem Cells 24 (2006) 2603-2610
    • (2006) Stem Cells , vol.24 , pp. 2603-2610
    • Dingli, D.1    Michor, F.2
  • 119
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi S.P., Rochon Y., Franza B.R., et al. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19 (1999) 1720-1730
    • (1999) Mol Cell Biol , vol.19 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3
  • 120
    • 33846165487 scopus 로고    scopus 로고
    • Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
    • Lu P., Vogel C., Wang R., et al. Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat Biotechnol 25 (2007) 117-124
    • (2007) Nat Biotechnol , vol.25 , pp. 117-124
    • Lu, P.1    Vogel, C.2    Wang, R.3
  • 121
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold R., and Mann M. Mass spectrometry-based proteomics. Nature 422 (2003) 198-207
    • (2003) Nature , vol.422 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 122
  • 123
    • 33644524918 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics turns quantitative
    • Ong S.E., and Mann M. Mass spectrometry-based proteomics turns quantitative. Nat Chem Biol 1 (2005) 252-262
    • (2005) Nat Chem Biol , vol.1 , pp. 252-262
    • Ong, S.E.1    Mann, M.2
  • 124
    • 34547572949 scopus 로고    scopus 로고
    • Is proteomics the new genomics?
    • Cox J., and Mann M. Is proteomics the new genomics?. Cell 130 (2007) 395-398
    • (2007) Cell , vol.130 , pp. 395-398
    • Cox, J.1    Mann, M.2
  • 125
    • 33750095125 scopus 로고    scopus 로고
    • Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS
    • Kang J.H., Park K.K., Lee I.S., et al. Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS. J Proteome Res 5 (2006) 2620-2631
    • (2006) J Proteome Res , vol.5 , pp. 2620-2631
    • Kang, J.H.1    Park, K.K.2    Lee, I.S.3
  • 126
    • 33751080360 scopus 로고    scopus 로고
    • Proteomic analysis of the E2F1 response in p53-negative cancer cells: new aspects in the regulation of cell survival and death
    • Li Z., Kreutzer M., Mikkat S., et al. Proteomic analysis of the E2F1 response in p53-negative cancer cells: new aspects in the regulation of cell survival and death. Proteomics 6 (2006) 5735-5745
    • (2006) Proteomics , vol.6 , pp. 5735-5745
    • Li, Z.1    Kreutzer, M.2    Mikkat, S.3
  • 127
    • 33745633851 scopus 로고    scopus 로고
    • Molecular determinants of differential sensitivity to docetaxel and paclitaxel in human pediatric cancer models
    • Izbicka E., Campos D., Marty J., et al. Molecular determinants of differential sensitivity to docetaxel and paclitaxel in human pediatric cancer models. Anticancer Res 26 (2006) 1983-1988
    • (2006) Anticancer Res , vol.26 , pp. 1983-1988
    • Izbicka, E.1    Campos, D.2    Marty, J.3
  • 128
    • 21644484845 scopus 로고    scopus 로고
    • The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-apoptotic effect of IFNalpha on pleomorphic sarcoma cells
    • Gazziola C., Cordani N., Carta S., et al. The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-apoptotic effect of IFNalpha on pleomorphic sarcoma cells. Int J Oncol 26 (2005) 129-140
    • (2005) Int J Oncol , vol.26 , pp. 129-140
    • Gazziola, C.1    Cordani, N.2    Carta, S.3
  • 129
    • 35448932301 scopus 로고    scopus 로고
    • Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines
    • Zanini C., Giribaldi G., Mandili G., et al. Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. J Neurochem 103 (2007) 1344-1354
    • (2007) J Neurochem , vol.103 , pp. 1344-1354
    • Zanini, C.1    Giribaldi, G.2    Mandili, G.3
  • 130
    • 0026755773 scopus 로고
    • Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids
    • Hosokawa N., Hirayoshi K., Kudo H., et al. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol Cell Biol 12 (1992) 3490-3498
    • (1992) Mol Cell Biol , vol.12 , pp. 3490-3498
    • Hosokawa, N.1    Hirayoshi, K.2    Kudo, H.3
  • 131
    • 0028951778 scopus 로고
    • Quercetin suppresses heat shock response by down regulation of HSF1
    • Nagai N., Nakai A., and Nagata K. Quercetin suppresses heat shock response by down regulation of HSF1. Biochem Biophys Res Commun 208 (1995) 1099-1105
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 1099-1105
    • Nagai, N.1    Nakai, A.2    Nagata, K.3
  • 132
    • 0033063289 scopus 로고    scopus 로고
    • The Ewing family of tumors and the search for the Achilles' heel
    • Kovar H., Aryee D., and Zoubek A. The Ewing family of tumors and the search for the Achilles' heel. Curr Opin Oncol 11 (1999) 275-284
    • (1999) Curr Opin Oncol , vol.11 , pp. 275-284
    • Kovar, H.1    Aryee, D.2    Zoubek, A.3
  • 133
    • 0034383949 scopus 로고    scopus 로고
    • The regulation of protein function by multisite phosphorylation-a 25 year update
    • Cohen P. The regulation of protein function by multisite phosphorylation-a 25 year update. Trends Biochem Sci 25 (2000) 596-601
    • (2000) Trends Biochem Sci , vol.25 , pp. 596-601
    • Cohen, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.