Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS

Journal of Proteome Research

Volumn 5, Issue 10, 2006, Pages 2620-2631

  Kang, Jeong Han ^a   Park, Kwan Kyu ^a   Lee, In Seon ^b   Magae, Junji ^c   Ando, Kunio ^d   Kim, Cheorl Ho ^e   Chang, Young Chae ^a  

^a Catholic University of Daegu   (South Korea)

^b Keimyung University   (South Korea)

^c INSTITUTE OF RESEARCH AND INNOVATION   (Japan)

^d NRL Pharma Inc   (Japan)

^e Sungkyunkwan University   (South Korea)

Author keywords

2 D gel; Ascochlorin; Human osteosarcoma cells; MALDI TOF MS

Indexed keywords

ADENOSINE TRIPHOSPHATE DEPENDENT RNA HELICASE; ASCOCHLORIN; CHOLESTEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIMERASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MINICHROMOSOME MAINTENANCE PROTEIN; MINICHROMOSOME MAINTENANCE PROTEIN 7; MITOGEN ACTIVATED PROTEIN KINASE 1; PHENOL; PRENYLAMINE; PROTEIN; RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN L; RIBULOSE 5 PHOSPHATE EPIMERASE; RNA HELICASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; ASCOCHYTA VICIAE; BIOINFORMATICS; CANCER; CANCER CELL CULTURE; CELL STRAIN U2OS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FUNGUS; HUMAN; HUMAN CELL; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; TUMOR; TWO DIMENSIONAL GEL ELECTROPHORESIS; UNINDEXED SEQUENCE; WESTERN BLOTTING; ZYMOGRAPHY;

ALKENES; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BONE NEOPLASMS; CELL LINE, TUMOR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; NEOPLASM PROTEINS; OSTEOSARCOMA; PHENOLS; PROTEOME; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR MARKERS, BIOLOGICAL;

ASCOCHYTA; FUNGI;

EID: 33750095125     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr060111i     Document Type: Article

References (52)

1. Tamura, G.; Suzuki, S.; Takatsuki, A.; Ando, K.; Arima, K. Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I). J. Antibiot. (Tokyo) 1968, 21, 539-544.
2. Sawada, M.; Hosokawa, T.; Okutomi, T.; Ando, K.; Hypolipidemic property of ascofuranone. J. Antibiot. (Tokyo) 1973, 26, 681-686.
3. Hosokawa, T.; Ando, K.; Tamura, G.; Effect of oral treatment with a new hypoglycemic agent, AS-6, on the metabolic activities of adipocytes in db/db mice: a comparative study. Biochem. Biophys. Res. Commun. 1985, 126, 471-476.
4. Hosokawa, T.; Sawada, M.; Ando, K.; Tamura, G.; Alteration of cholesterol metabolism by 4-O-methylascochlorin in rats. Lipids 1981, 16, 433-438.
5. Magae, J.; Suzuki, S.; Nagai, K.; Yamasaki, M.; Ando, K.; Tamura, G. In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system. Cancer Res. 1986, 46 (3), 1073-1078.
6. Magae, J.; Hayasaki, J.; Matsuda, Y.; Hotta, M.; Hosokawa, T.; Suzuki, S.; Nagai, K.; Ando, K.; Tamura, G. Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes. J. Antibiot. (Tokyo) 1988, 41 (7), 959-965.
7. Ando, M.; Hirosaki, S.; Tamura, K.; Taya, T. Multiple regression analysis of the cholinesterase activity with certain physiochemical factors. Environ. Res. 1984, 33 (1), 96-105.
8. Overall, C. M.; Wrana, J. L.; Sodek, J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J. Biol. Chem. 1989, 264 (3), 1860-1869.
9. Togashi, M.; Ozawa, S.; Abe, S.; Nishimura, T.; Tsuruga, M.; Ando, K.; Tamura, G.; Kuwahara, S.; Ubukata, M.; Magae, J. Ascochlorin derivatives as ligands for nuclear hormone receptors. J. Med. Chem. 2003, 46 (19), 4113-4123.
10. Takatsuki, A.; Tamura, G.; Arima, K. Antiviral and antitumor antibiotics. XIV. Effects of ascochlorin and other respiration inhibitors on multiplication of Newcastle disease virus in cultured cells. Appl. Microbiol. 1969, 17 (6), 825-982.
11. Magae, J.; Munemura, K.; Ichikawa, C.; Osada, K.; Hanada, T.; Tsuji, R. F.; Yamashita, M.; Hino, A.; Horiuchi, T.; Uramoto, M.; et al. Effects of microbial products on glucose consumption and morphology of macrophages. Biosci., Biotechnol, Biochem. 1993, 57 (10), 1628-1631.
12. Togashi, M.; Masuda, H.; Kawada, T.; Tanaka, M.; Saida, K.; Ando, K.; Tamura, G.; Magae, J. PPARgamma activation and adipocyte differentiation induced by AS-6, a prenyl-phenol antidiabetic antibiotic. J. Antibiot. (Tokyo) 2002, 55, 417-422.
13. MP, L.; Eilber, F. Pediatric Osteosarcoma; Lippincott: Philadelphia, 1989.
14. Ferguson, W. S.; Goorin, A. M. Current treatment of osteosarcoma. Cancer Invest. 2001, 19 (3), 292-315.
15. Marina, N. M.; Pratt, C. B.; Rao, B. N.; Shema, S. J.; Meyer, W. H. Improved prognosis of children with osteosarcoma metastatic to the lung(s) at the time of diagnosis. Cancer 1992, 70 (11), 2722-2727.
16. Bjellqvist, B.; Ek, K.; Righetti, P. G.; Gianazza, E.; Gorg, A.; Westermeier, R.; Postel, W. Isoelectric focusing in immobilized pH gradients: principle, methodology and some applications. J. Biochem. Biophys. Methods 1982, 6 (4), 317-339.
17. Neuhoff, V.; Arold, N.; Taube, D.; Ehrhardt, W. Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250. Electrophoresis 1988, 9 (6), 255-262.
18. Hong, S.; Park, K. K.; Magae, J.; Ando, K.; Lee, T. S.; Kwon, T. K.; Kwak, J. Y.; Kim, C. H.; Chang, Y. C. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK 1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J. Biol. Chem. 2005, 280 (26), 25202-25209.
19. Chung, T. W.; Lee, Y. C.; Kim, C. H. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004, 18 (10), 1123-1125.
20. Graham, D. E.; Xu, H.; White, R. H. A divergent archaeal member of the alkaline phosphatase binuclear metalloenzyme superfamily has phosphoglycerate mutase activity. FEBS Lett. 2002, 517 (1-3), 190-194.
21. Boraldi, P.; Bini, L.; Liberatori, S.; Armini, A.; Pallini, V.; Tiozzo, R.; Pasquali-Ronchetti, I.; Quaglino, D. Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages. Proteomics 2003, 3 (6), 917-929.
22. Rigden, D. J.; Lamani, E.; Mello, L. V.; Littlejohn, J. E.; Jedrzejas, M. J. Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling. J. Mol. Biol. 2003, 328 (4), 909-920.
23. Wattenberg, L. W.; Chemoprevention of cancer. Cancer Res. 1985, 45 (1), 1-8.
24. Durany, N.; Joseph, J.; Jimenez, O. M.; Climent, F.; Fernandez, P. L.; Rivera, P.; Carreras, J. Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma. Br. J. Cancer 2000, 82 (1), 20-27.
25. Fairchild, T. A.; Patejunas, G. Cloning and expression profile of human inorganic pyrophosphatase. Biochim. Biophys. Acta 1999, 1447 (2-3), 133-136.
26. Islam, M. K.; Miyoshi, T.; Kasuga-Aoki, H.; Isobe, T.; Arakawa, T.; Matsumoto, Y.; Tsuji, N. Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites. Eur. J. Biochem. 2003, 270 (13), 2814-2826.
27. Yoshida, C.; Shah, H.; Weinhouse, S. Purification and properties of inorganic pyrophosphatase of rat liver and hepatoma 3924A. Cancer Res. 1982, 42 (9), 3526-3531.
28. Satoh, T.; Samejima, T.; Watanabe, M.; Nogi, S.; Takahashi, Y.; Kaji, H.; Teplyakov, A.; Obmolova, G.; Kuranova, I.; Ishii, K. Molecular cloning, expression, and site-directed mutagenesis of inorganic pyrophosphatase from Thermus thermophilus HB8. J. Biochem. (Tokyo) 1998, 124 (1), 79-88.
29. Flynn, T. G. Aldehyde reductases: monomeric NADPH-dependent oxidoreductases with multifunctional potential. Biochem. Pharmacol. 1982, 31 (17), 2705-2712.
30. Barski, O. A.; Gabbay, K. H.; Grimshaw, C. E.; Bohren, K. M. Mechanism of human aldehyde reductase: characterization of the active site pocket. Biochemistry 1995, 34 (35), 11264-11275.
31. Seliger, B.; Menig, M.; Lichtenfels, R.; Atkins, D.; Bukur, J.; Halder, T. M.; Kersten, M.; Harder, A.; Ackermann, A.; Beck, J.; Muehlenweg, B.; Brenner, W.; Melchior, S.; Kellner, R.; Lottspeich, F. Identification of markers for the selection of patients undergoing renal cell carcinoma-specific immunotherapy. Proteomics 2003, 3 (6), 979-990.
32. Weber, A.; Pennise, C. R.; Babcock, G. G.; Fowler, V. M. Tropomodulin caps the pointed ends of actin filaments. J. Cell. Biol. 1994, 127 (6 Pt 1), 1627-1635.
33. Littlefield, R.; Almenar-Queralt, A.; Fowler, V. M. Actin dynamics at pointed ends regulates thin filament length in striated muscle. Nat. Cell Biol. 2001, 3 (6), 544-551.
34. Droz, D.; Zachar, D.; Charbit, L.; Gogusev, J.; Chretein, Y.; Iris, L.; Expression of the human nephron differentiation molecules in renal cell carcinomas. Am. J. Pathol. 1990, 137 (4), 895-905.
35. Mendelsohn, J.; Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene 2000, 19 (56), 6550-6565.
36. de Bono, J. S.; Rowinsky, E. K. The ErbB receptor family: a therapeutic target for cancer. Trends Mol. Med. 2002, 8 (4 Suppl), S19-26.
37. Woodburn, J. R. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol. Ther. 1999, 82 (2-3), 241-250.
38. Arteaga, C. L. Epidermal growth factor receptor dependence in human tumors: more than just expression? Oncologist 2002, 7 Suppl 4, 31-39.
39. Khazaie, K.; Schirrmacher, V.; Lichtner, R. B. EGF receptor in neoplasia and metastasis. Cancer Metastasis Rev. 1993, 12 (3-4), 255-274.
40. Brabender, J.; Danenberg, K. D.; Metzger, R.; Schneider, P. M.; Park, J.; Salonga, D.; Holscher, A. H.; Danenberg, P. V. Epidermal growth factor receptor and HER2-neu mRNA expression in nonsmall cell lung cancer is correlated with survival. Clin. Cancer Res. 2001, 7 (7), 1850-1855.
41. Ciardiello, F.; Tortora, G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin. Cancer Res. 2001, 7 (10), 2958-2970.
42. Fan, X.; Krahling, S.; Smith, D.; Williamson, P.; Schlegel, R. A. Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. Mol. Biol. Cell 2004, 15 (6), 2863-2872.
43. Sharp, T. V.; Munoz, F.; Bourboulia, D.; Presneau, N.; Darai, E.; Wang, H. W.; Cannon, M.; Butcher, D. N.; Nicholson, A. G.; Klein, G.; Imreh, S.; Boshoff, C. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (47), 16531-16536.
44. Charette, S. J.; Lavoie, J. N.; Lambert, H.; Landry, J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell. Biol. 2000, 20 (20), 7602-7612.
45. Elliott, K.; Sakamuro, D.; Basu, A.; Du, W.; Wunner, W.; Staller, P.; Gaubatz, S.; Zhang, H.; Prochownik, E.; Eilers, M.; Prendergast, G. C. Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene 1999, 18 (24), 3564-3573.
46. Prendergast, G. C.; Mechanisms of apoptosis by c-Myc. Oncogene 1999, 18 (19), 2967-2987.
47. Fusaro, G.; Dasgupta, P.; Rastogi, S.; Joshi, B.; Chellappan, S. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J. Biol. Chem. 2003, 278 (48), 47853-47861.
48. Nagase, H.; Woessner, J. F., Jr. Matrix metalloproteinases. J. Biol. Chem. 1999, 274 (31), 21491-21494.
49. Caraglia, M.; Budillon, A.; Vitale, G.; Lupoli, G.; Tagliaferri, P.; Abbruzzese, A. Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation. Eur. J. Biochem. 2000, 267 (13), 3919-3936.
50. Jin, B. F.; He, K.; Wang, H. X.; Wang, J.; Zhou, T.; Lan, Y.; Hu, M. R.; Wei, K. H.; Yang, S. C.; Shen, B. F.; Zhang, X. M. Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A. Oncogene 2003, 22 (31), 4819-4830.
51. Tsao, C. C.; Geisen, C.; Abraham, R. T. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 2004, 23 (23), 4660-4669.
52. Hosokawa, T.; Ando, K.; Tamura, G. An ascochlorin derivative, AS-6, reduces insulin resistance in the genetically obese diabetic mouse, db/db. Diabetes 1985, 34 (3), 267-274.