Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and γ-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9443-9449

  Yadav, Mange Ram ^a   Pawar, Vijay P ^a   Marvaniya, Sejal M ^a   Halen, Parmeshwari K ^a   Giridhar, Rajani ^a   Mishra, Anil K ^b  

^a Faculty of Technology and Engineering   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Imaging studies; Anti inflammatory activity; NSAIDs; Site specific delivery; Tropinol

Indexed keywords

6 METHOXY 2 NAPHTHYLACETIC ACID; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 ACETATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 2 (2 FLUORO 4 BIPHENYL)PROPIONATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 2 (3 BENZOYLPHENYL)PROPIONATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 2 (4 ISOBUTYLPHENYL)PROPIONATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 2 (6 METHOXY 2 NAPHTHYL)PROPIONATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 4 BIPHENYLACETATE METHIODIDE; 8 METHYL 8 AZABICYCLO[3,2,1]OCTAN 3 YL 6 METHOXY 2 NAPHTHYLACETATE METHIODIDE; DRUG METABOLITE; ESTER DERIVATIVE; FELBINAC; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; KETOPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; QUATERNARY AMMONIUM DERIVATIVE; TECHNETIUM 99M; TROPINOL ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; IMAGING; ISOTOPE LABELING; NONHUMAN; RAT; SCINTIGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CARRAGEENAN; EDEMA; ESTERS; GAMMA CAMERAS; HUMANS; INFLAMMATION; KNEE JOINT; MAGNETIC RESONANCE SPECTROSCOPY; MALE; ORGANOTECHNETIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

RODENTIA;

EID: 53749088838     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.050     Document Type: Article

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