New quaternary ammonium oxicam derivatives targeted toward cartilage: Synthesis, pharmacokinetic studies, and antiinflammatory potency

Journal of Medicinal Chemistry

Volumn 42, Issue 25, 1999, Pages 5235-5240

  Nicolas, Colette ^a   Verny, Michel ^a   Giraud, Isabelle ^a   Ollier, Monique ^a   Rapp, Maryse ^a   Maurizis, Jean Claude ^a   Madelmont, Jean Claude ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INDOMETACIN; INTERLEUKIN 1BETA; OXICAM DERIVATIVE; PIROXICAM DERIVATIVE; PROPOXICAM DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTICULAR CARTILAGE; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; DRUG TARGETING; NONHUMAN; PROTEOGLYCAN SYNTHESIS; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CARTILAGE, ARTICULAR; CELLS, CULTURED; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTEOGLYCANS; QUATERNARY AMMONIUM COMPOUNDS; RABBITS; RATS; THIAZINES;

EID: 0033576567     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991120o     Document Type: Article

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