Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity

Archives of Biochemistry and Biophysics

Volumn 479, Issue 1, 2008, Pages 82-87

  Carbone, Vincenzo ^a   Chung, Roland ^a   Endo, Satoshi ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

20 Hydroxysteroid dehydrogenase; 3,5 Dichlorosalicylic acid; Aldehyde reductase; Aldo keto reductase; Enzyme inhibition; Inhibitor selectivity; Molecular modelling; Protein structure; X ray crystallography

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3,5 DICHLOROSALICYLIC ACID; ALDEHYDE REDUCTASE; AMINO ACID; ARGININE; HISTIDINE; HYDROXYSTEROID DEHYDROGENASE; LEUCINE; OXIDOREDUCTASE INHIBITOR; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SALICYLIC ACID DERIVATIVE; TOLRESTAT; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADP; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SALICYLIC ACIDS; SWINE; X-RAY DIFFRACTION;

EID: 53649102652     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.08.014     Document Type: Article

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