A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20α-hydroxysteroid dehydrogenase

Medicinal Chemistry

Volumn 3, Issue 6, 2007, Pages 546-550

  Dhagat, Urmi ^a   Carbone, Vincenzo ^a   Chung, Roland P T ^a   Matsunaga, Toshihiro ^a   Endo, Satoshi ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

20 hydroxysteroid dehydrogenase; Aldo keto reductase; Enzyme inhibitors; Molecular docking; Salicylic acid

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3 PHENYL 4,5 ISOXAZOLEDIONE 4 OXIME; 3',3',5',5' TETRABROMOPHENOLPHTHALEIN; 3,5 DIIODOSALICYLIC ACID; 3,5 DINITRO 4 HYDROXYPHENYLACETIC ACID; 3,5 DINITRO 4 TOLUIC ACID; 4 BENZOYLPYRIDINE; ACETYLSALICYLIC ACID; ANTHRAQUINONE 2 CARBOXYLIC ACID; BENZBROMARONE; ENZYME INHIBITOR; LIGAND; N BENZYL 2,2,2 TRIFLUOROACETAMIDE; OXIDOREDUCTASE INHIBITOR; PREGNANEDIOL; PROGESTERONE; SALICYLIC ACID; SALICYLIC ACID DERIVATIVE; STEROID HORMONE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CARCINOGENESIS; CARDIOVASCULAR DISEASE; CATAMENIAL EPILEPSY; CHEMICAL ANALYSIS; DEPRESSION; DRUG POTENCY; DRUG SCREENING; ENDOMETRIOSIS; ENDOMETRIUM CANCER; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HEADACHE; HORMONE METABOLISM; HUMAN; IC 50; KINETICS; MALIGNANT NEOPLASTIC DISEASE; NEUROLOGIC DISEASE; PREGNANCY TERMINATION; PREMATURITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK REDUCTION;

20-HYDROXYSTEROID DEHYDROGENASES; BINDING SITES; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; PROTEIN BINDING; SALICYLIC ACID;

EID: 37349053079     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607782360399     Document Type: Article

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