Selectivity determinants of inhibitor binding to human 20α- hydroxysteroid dehydrogenase: Crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4844-4848

  Dhagat, Urmi ^a   Endo, Satoshi ^b   Sumii, Rie ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3,5 DICHLOROSALICYLIC ACID; ANTINEOPLASTIC AGENT; HISTIDINE; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; COENZYME; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; MUTAGENESIS;

20-ALPHA-HYDROXYSTEROID DEHYDROGENASE; BINDING SITES; COENZYMES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SALICYLIC ACIDS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 49449097049     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8003575     Document Type: Article

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