Animal Models for Gender-Based Skeletal Differences

Principles of Gender-Specific Medicine

Volumn 2, Issue , 2004, Pages 1043-1051

  Vanderschueren, Dirk ^a   Venken, Katrien ^a   Bouillon, Roger ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 53549103824     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012440905-7/50370-4     Document Type: Chapter

References (79)

1. Seeman E Clinical review 137: Sexual dimorphism in skeletal size, density, and strength. J Clin Endocrinol Metab 2001, 86:4576-4584.
2. Vidal O, Lindberg MK, Hollberg K, et al. Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A 2000, 97:5474-5479.
3. Frost HM Bone "mass" and the "mechanostat": A proposal. Anat Rec 1987, 219:1-9.
4. Frost HM A determinant of bone architecture. The minimum effective strain. Clin Orthop 1983, 175:286-292.
5. Sheng MH, Baylink DJ, Beamer WG, et al. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 1999, 25:421-429.
6. Sheng MH, Baylink DJ, Beamer WG, et al. Regulation of bone volume is different in the metaphyses of the femur and vertebra of C3H/HeJ and C57BL/6J mice. Bone 2002, 30:486-491.
7. Mosley JR, Lanyon LE Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain. Bone 2002, 30:314-319.
8. Saville PD Changes in skeletal mass and fragility with castration in the rat; a model of osteoporosis. J Am Geriatr Soc 1969, 17:155-166.
9. Zanchetta JR, Plotkin H, Alvarez Filgueira ML Bone mass in children: Normative values for the 2-20-year-old population. Bone 1995, 16:393S-399S.
10. Schiessl H, Frost HM, Jee WS Estrogen and bone-muscle strength and mass relationships. Bone 1998, 22:1-6.
11. Damien E, Price JS, Lanyon LE The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain. J Bone Miner Res 1998, 13:1275-1282.
12. Damien E, Price JS, Lanyon LE Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females. J Bone Miner Res 2000, 15:2169-2177.
13. Turner RT, Hannon KS, Demers LM, et al. Differential effects of gonadal function on bone histomorphometry in male and female rats. J Bone Miner Res 1989, 4:557-563.
14. Rosen HN, Tollin S, Balena R, et al. Bone density is normal in male rats treated with finasteride. Endocrinology 1995, 136:1381-1387.
15. Schoutens A, Verhas M, L'hermite-Baleriaux M, et al. Growth and bone haemodynamic responses to castration in male rats. Reversibility by testosterone. Acta Endocrinol (Copenh) 1984, 107:428-432.
16. Wink CS, Felts WJ Effects of castration on the bone structure of male rats: A model of osteoporosis. Calcif Tissue Int 1980, 32:77-82.
17. Gunness M, Orwoll E Early induction of alterations in cancellous and cortical bone histology after orchiectomy in mature rats. J Bone Miner Res 1995, 10:1735-1744.
18. Turner RT, Wakley GK, Hannon KS Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J Orthop Res 1990, 8:612-617.
19. Vanderschueren D, Van Herck E, Geusens P, et al. Androgen resistance and deficiency have different effects on the growing skeleton of the rat. Calcif Tissue Int. 1994, 55:198-203.
20. Vanderschueren D, Van Herck E, Nijs J, et al. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 1997, 138:2301-2307.
21. Zhang XZ, Kalu DN, Erbas B, et al. The effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific. J Bone Miner Res. 1999, 14:802-809.
22. Gaumet-Meunier N, Coxam V, Robins S, et al. Gonadal steroids and bone metabolism in young castrated male rats. Calcif Tissue Int. 2000, 66:470-475.
23. Wronski TJ, Dann LM, Horner SL Time course of vertebral osteopenia in ovariectomized rats. Bone 1989, 10:295-301.
24. Kalu DN, Liu CC, Hardin RR, Hollis BW The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 1989, 124:7-16.
25. Wronski TJ, Dann LM, Scott KS, Crooke LR Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats. Endocrinology 1989, 125:810-816.
26. Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA Skeletal alterations in ovariectomized rats. Calcif Tissue Int. 1985, 37:324-328.
27. Wronski TJ, Dann LM, Scott KS, Crooke LR Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats. Endocrinology 1989, 125:810-816.
28. Wakley GK, Schutte HD, Hannon KS, Turner RT Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res. 1991, 6:325-330.
29. Wronski TJ, Cintron M, Doherty AL, Dann LM Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 1988, 123:681-686.
30. Vanderschueren D, Van Herck E, Suiker AM, et al. Bone and mineral metabolism in aged male rats: Short and long term effects of androgen deficiency. Endocrinology 1992, 130:2906-2916.
31. Verhas M, Schoutens A, L'hermite-Baleriaux M, et al. The effect of orchidectomy on bone metabolism in aging rats. Calcif Tissue Int. 1986, 39:74-77.
32. Vanderschueren D, Van Herck E, Schot P, et al. The aged male rat as a model for human osteoporosis: Evaluation by nondestructive measurements and biomechanical testing. Calcif Tissue Int. 1993, 53:342-347.
33. Erben RG, Eberle J, Stahr K, Goldberg M Androgen deficiency induces high turnover osteopenia in aged male rats: A sequential histomorphometric study. J Bone Miner Res. 2000, 15:1085-1098.
34. Verhaeghe J, van Bree R, Van Herck E, et al. Effects of recombinant human growth hormone and insulin-like growth factor-I, with or without 17 beta-estradiol, on bone and mineral homeostasis of aged ovariectomized rats. J Bone Miner Res. 1996, 11:1723-1735.
35. Vanderschueren D, Van Herck E, Suiker AM, et al. Bone and mineral metabolism in the androgen-resistant (testicular feminized) male rat. J Bone Miner Res. 1993, 8:801-809.
36. Lindberg MK, Moverare S, Skrtic S, et al. Two different pathways for the maintenance of trabecular bone in adult male mice. J Bone Miner Res. 2002, 17:555-562.
37. Cutler GB The role of estrogen in bone growth and maturation during childhood and adolescence. J Steroid Biochem Mol Biol. 1997, 61:141-144.
38. Turner RT, Lifrak ET, Beckner M, et al. Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats. Am J Physiol. 1990, 258:E673-E677.
39. Turner RT, Evans GL, Wakley GK Spaceflight results in depressed cancellous bone formation in rat humeri. Aviat Space Environ Med. 1995, 66:770-774.
40. Cavolina JM, Evans GL, Harris SA, et al. The effects of orbital spaceflight on bone histomorphometry and messenger ribonucleic acid levels for bone matrix proteins and skeletal signaling peptides in ovariectomized growing rats. Endocrinology 1997, 138:1567-1576.
41. Bikle D, Majumdar S, Laib A, et al. The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res. 2001, 16:2320-2329.
42. Liu JP, Baker J, Perkins AS, et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993, 75:59-72.
43. Powell-Braxton L, Hollingshead P, Warburton C, et al. IGF-I is required for normal embryonic growth in mice. Genes Dev. 1993, 7:2609-2617.
44. Zhou Y, Xu BC, Maheshwari HG, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A 1997, 94:13215-13220.
45. Sjogren K, Bohlooly YM, Olsson B, et al. Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice. Biochem Biophys Res Commun 2000, 267:603-608.
46. Sims NA, Clement-Lacroix P, Da Ponte F, et al. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest. 2000, 106:1095-1103.
47. Jansson JO, Ekberg S, Isaksson OG, Eden S Influence of gonadal steroids on age- and sex-related secretory patterns of growth hormone in the rat. Endocrinology 1984, 114:1287-1294.
48. Jansson JO, Eden S, Isaksson O Sexual dimorphism in the control of growth hormone secretion. Endocr Rev. 1985, 6:128-150.
49. Bouillon R, Bex M, Van Herck E, et al. Influence of age, sex, and insulin on osteoblast function: Osteoblast dysfunction in diabetes mellitus. J Clin Endocrinol Metab 1995, 80:1194-1202.
50. Handelsman DJ, Spaliviero JA, Scott CD, Baxter RC Hormonal regulation of the peripubertal surge of insulin-like growth factor-I in the rat. Endocrinology 1987, 120:491-496.
51. Windahl SH, Hollberg K, Vidal O, et al. Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss. J Bone Miner Res 2001, 16:1388-1398.
52. Lindberg MK, Alatalo SL, Halleen JM, et al. Estrogen receptor specificity in the regulation of the skeleton in female mice. J Endocrinol 2001, 171:229-236.
53. Oz OK, Zerwekh JE, Fisher C, et al. Bone has a sexually dimorphic response to aromatase deficiency. J Bone Miner Res 2000, 15:507-514.
54. Miyaura C, Toda K, Inada M, et al. Sex- and age-related response to aromatase deficiency in bone. Biochem Biophys Res Commun 2001, 280:1062-1068.
55. Vanderschueren D, Van Herck E, De Coster R, Bouillon R Aromatization of androgens is important for skeletal maintenance of aged male rats. Calcif Tissue Int 1996, 59:179-183.
56. Vanderschueren D, Boonen S, Ederveen AG, et al. Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model. Bone 2000, 27:611-617.
57. Jones MEE, Thorburn AW, Britt KL, et al. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A 2000, 97:12735-12740.
58. Vandenput L, Ederveen AG, Erben RG, et al. Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice. Biochem Biophys Res Commun 2001, 285:70-76.
59. Sims NA, Dupont S, Krust A, et al. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone 2002, 30:18-25.
60. Kousteni S, Bellido T, Plotkin LI, et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 2001, 104:719-730.
61. Bilezikian JP Sex steroids, mice, and men: When androgens and estrogens get very close to each other. J Bone Miner Res 2002, 17:563-566.
62. Turner RT, Evans GL, Dobnig H The high-affinity estrogen receptor antagonist ICI 182,780 has no effect on bone growth in young male rats. Calcif Tissue Int 2000, 66:461-464.
63. Vandenput L, Swinnen JV, Van Herck E, et al. The estrogen receptor ligand ICI 182,780 does not impair the bone-sparing effects of testosterone in the young orchidectomized rat model. Calcif Tissue Int 2002, 70:170-175.
64. Broulik PD, Starka L Effect of antiandrogens Casodex and epitestosterone on bone composition in mice. Bone 1997, 20:473-475.
65. Keenan BS, Richards GE, Ponder SW, et al. Androgen-stimulated pubertal growth: The effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 1993, 76:996-1001.
66. Kaplowitz HJ, Wild KA, Mueller WH, et al. Serial and parent-child changes in components of body fat distribution and fatness in children from the London Longitudinal Growth Study, ages two to eighteen years. Hum Biol 1988, 60:739-758.
67. Yao W, Jee WS, Chen J, et al. Making rats rise to erect bipedal stance for feeding partially prevented orchidectomy-induced bone loss and added bone to intact rats. J Bone Miner Res 2000, 15:1158-1168.
68. Gallagher A, Chambers TJ, Tobias JH The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats. Endocrinology 1993, 133:2787-2791.
69. Sibonga JD, Dobnig H, Harden RM, Turner RT Effect of the high-affinity estrogen receptor ligand ICI 182,780 on the rat tibia. Endocrinology 1998, 139:3736-3742.
70. Lea CK, Flanagan AM Ovarian androgens protect against bone loss in rats made oestrogen deficient by treatment with ICI 182,780. J Endocrinol 1999, 160:111-117.
71. Vidal O, Lindberg M, Savendahl L, et al. Disproportional body growth in female estrogen receptor-alpha-inactivated mice. Biochem Biophys Res Commun 1999, 265:569-571.
72. Gentile MA, Zhang H, Harada S, et al. Bone response to estrogen replacement in ovx double estrogen receptor-(alpha and beta) knockout mice. J Bone Miner Res 2001, 16:146.
73. Denger S, Reid G, Kos M, et al. ERalpha gene expression in human primary osteoblasts: Evidence for the expression of two receptor proteins. Mol Endocrinol 2001, 15:2064-2077.
74. Windahl SH, Vidal O, Andersson G, et al. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. J Clin Invest 1999, 104:895-901.
75. Lea C, Kendall N, Flanagan AM Casodex (a nonsteroidal antiandrogen) reduces cancellous, endosteal, and periosteal bone formation in estrogen-replete female rats. Calcif Tissue Int 1996, 58:268-272.
76. Goulding A, Gold E Flutamide-mediated androgen blockade evokes osteopenia in the female rat. J Bone Miner Res 1993, 8:763-769.
77. Gallagher A, Chambers TJ, Tobias JH Androgens contribute to the stimulation of cancellous bone formation by ovarian hormones in female rats. Am J Physiol 1996, 270:E407-E412.
78. Lea CK, Flanagan AM Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat. Am J Physiol 1998, 274:E328-E335.
79. Grumbach MM, Auchus RJ Estrogen: Consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 1999, 84:4677-4694.