Bone has a sexually dimorphic response to aromatase deficiency

Journal of Bone and Mineral Research

Volumn 15, Issue 3, 2000, Pages 507-514

  Öz, Orhan K ^a   Zerwekh, Joseph E ^a   Fisher, Carolyn ^b   Graves, Kathy ^a   Nanu, Lydia ^a   Millsaps, Rita ^a   Simpson, Evan R ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Aromatase; Bone; Estrogen; Mice; Osteoporosis

Indexed keywords

AROMATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE GROWTH; BONE MASS; ESTROGEN DEFICIENCY; FEMALE; FEMUR; HISTOPATHOLOGY; LUMBAR SPINE; MALE; MOUSE; NONHUMAN; OSTEOPOROSIS; SEX DIFFERENCE;

EID: 0034007390     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.3.507     Document Type: Article

References (30)

1. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061.
2. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689-3698.
3. Qin K, Fisher CR, Simpson ER, Serpente S, Faustini-Fustini M, Carani C 1996 Oligospermia and persistent linear growth of a male subject caused by a missense mutation in the gene encoding aromatase. Proceedings of the IVth International Aromatase Conference, Tahoe City, CA, U.S.A.
4. MacGillivray MH, Morishima A, Conte F, Grumbach M, Smith EP 1998 Pediatric endocrinology update: An overview. The essential roles of estrogens in pubertal growth, epiphyseal fusion and bone turnover: Lessons from mutations in the genes for aromatase and the estrogen receptor. Horm Res 49:(Suppl 1):2-8.
5. Bilezikian JP, Morishima A, Bell J, Grumbach MM 1998 Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599-603.
6. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER 1997 Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337:91-95.
7. Anderson FH, Francis RM, Selby PL, Cooper C 1998 Sex hormones and osteoporosis in men. Calcif Tissue Int 62:185-188.
8. Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC 1997 Sex steroids and bone mass in older men: Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100:1755-1759.
9. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L 1998 Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males. Clin Endocrinol 49:803-809.
10. Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274.
11. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA 1996 Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930.
12. Hanstein B, Liu H, Yancisin MC, Brown M 1999 Functional analysis of a novel estrogen receptor-β isoform. Mol Endocrinol 13:129-137.
13. Chu S, Fuller PH 1997 Identification of a splice variant of the rat estrogen receptor beta gene. Mol Cell Endocrinol 132:195-199.
14. Petersen DN, Kalcevic GTT, Koza-Taylor PH, Turi TG, Brown TA 1998 Identification of estrogen receptor beta2 a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology 139:1082-1092.
15. Vanderschueren D, van Herck E, Nijs J, Ederveen AGR, de Coster R, Bouillon R 1993 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 138:2301-2307.
16. Fisher CR, Graves KH, Parlow AF, Simpson ER 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp 19 gene. Proc Natl Acad Sci U S A 95:6965-6970.
17. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ 1996 Genetic variability in adult bone density among inbred strains of mice. Bone 18:397-403.
18. Zerwekh JE, Sakhaee K, Breslau NA, Gottschalk F, Pak CYC 1992 Impaired bone formation in male idiopathic osteoporosis: Further reduction in the presence of concomitant hypercalciuria. Osteoporos Int 2:128-134.
19. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: standardization of nomenclature, symbols and units. J Bone Miner Res 2:595-610.
20. Shozu M, Simpson ER 1998 Aromatase expression of human osteoblast-like cells. Mol Cell Endocrinol 139:117-129.
21. Nawata J, Tanaka S, Tanaka S, Takayanagi R, Sakai Y, Yanase T, lkuyama S, Haji M 1995 Aromatase in bone cell: assocation with osteoporosis in postmenopausal women. J Steroid Biochem Mol Biol 53:165-174.
22. Eyre LJ, Bland R, Bujalska J, Sheppard M, Stewart PM, Hewison M 1998 Characterization of aromatase and 17β-hydroxysteroid dehydrogenase expression in rat osteoblastic cells. J Bone Miner Res 13:996-1004.
23. Shozu M, Zhao Y, Simpson ER 1997 Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene. Endocrinology 138:5125-5135.
24. Schweikert H-U, Wolf L, Romalo G 1995 Oestrogen formation from androstenedione in human bone. Clin Endocrinol 43: 37-42.
25. Sasano H, Uzuki M, Sawai T, Nagura H, Matsunaga G, Kashimoto O, Harada N 1997 Aromatase in human bone tissue. J Bone Miner Res 12:1416-1423.
26. Grazioli V, Massimo A, Stenico A, Casari E 1996 Urinary output of hydroxylysine glycosides and pyridinium cross-links in detecting rat bone collagen turnover rate. FEBS Lett 388:134-138.
27. Taxel P, Raisz LG 1998 The effect of an aromatase inhibitor on bone turnover in older men. Bone 23(Suppl):S178 (abstract).
28. Arjmandi BH, Alekel L, Hollis BW 1996 Dietary soybean protein prevents bone loss in an ovarectomized rat model of osteoporosis. J Nutr 126:161-167.
29. Orwoll ES 1996 Androgens. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology, Academic Press, San Diego, CA, U.S.A., pp. 563-580.
30. Vanderschueren D, Boonen S, Bouilllon R 1998 Action of androgens versus estrogens in male skeletal homeostasis. Bone 23:391-394.