The effects of orbital space flight on bone histomorphometry and messenger ribonucleic acid levels for bone matrix proteins and skeletal signaling peptides in ovariectomized growing rats

Endocrinology

Volumn 138, Issue 4, 1997, Pages 1567-1576

  Cavolina, Jason M ^a   Evans, Glenda L ^a   Harris, Steven A ^a   Zhang, Minzhi ^a   Westerlind, Kim C ^a   Turner, Russell T ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; MESSENGER RNA; BONE MORPHOGENETIC PROTEIN; RIBONUCLEASE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE GROWTH; BONE MATRIX; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; ESTROGEN THERAPY; HORMONE DEFICIENCY; IMMOBILIZATION; MORPHOMETRICS; MUSCULOSKELETAL SYSTEM; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; RAT; SPACE FLIGHT; ANIMAL; BONE; BONE DEVELOPMENT; CYTOLOGY; FEMALE; FISCHER 344 RAT; FLIGHT EXPERIMENT; GENETICS; MANNED; METABOLISM; NASA DISCIPLINE NUMBER 00-00; NASA DISCIPLINE NUMBER 18-10; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NASA PROGRAM FLIGHT; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES; NON-NASA CENTER; NORTHERN BLOTTING; OSTEOLYSIS; OVARIECTOMY; SHORT DURATION; STS-62 SHUTTLE PROJECT; WEIGHTLESSNESS;

NASA DISCIPLINE NUMBER 00-00; NASA DISCIPLINE NUMBER 18-10; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NASA PROGRAM FLIGHT; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES; NON-NASA CENTER;

FLIGHT EXPERIMENT; MANNED; SHORT DURATION; STS-62 SHUTTLE PROJECT;

ANIMALS; BLOTTING, NORTHERN; BONE AND BONES; BONE MORPHOGENETIC PROTEINS; BONE RESORPTION; FEMALE; OSTEOGENESIS; OVARIECTOMY; PROTEIN SORTING SIGNALS; RATS; RATS, INBRED F344; RIBONUCLEASES; RNA, MESSENGER; SPACE FLIGHT; WEIGHTLESSNESS;

EID: 85047680931     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.4.5040     Document Type: Article

References (57)

1. Turner RT, Evans GL, Wakley GK 1995 Spaceflight results in depressed cancellous bone formation in rat humeri. Aviat Space Environ Med 66:770-774
2. Fowler Jr JF 1991 Physiology changes during spaceflight. Cutis 48:291-295
3. Vico L, Alexandre C 1992 Microgravity and bone adaptation at the tissue level. J Bone Miner Res [Suppl 2] 7:S445-S447 (Review)
4. Morey ER, Baylink DJ 1978 Inhibition of bone formation during spaceflight. Science 201:1138-1141
5. Spengler DM, Morey ER, Carter DR, Turner RT, Baylink DJ 1983 Effects of spaceflight on structural and material strength of growing bone. Proc Soc Exp Biol Med 174:224-228
6. Spengler DM, Morey ER, Carter DR, Turner RT, Baylink DJ 1979 Effects of spaceflight on bone strength. Physiologist 22:S75-S76
7. Wronski TJ, Morey ER 1983 Effects of spaceflight on periosteal bone formation in rats. Am J Physiol 244:R305-R309
8. Vico L, Bourrin S, Genty C, Palle S, Alexandre C 1993 Histomorphometric analysis of cancellous bone from COSMOS 2044 rats. J Appl Physiol 75:2203-2208
9. Wronski TJ, Morey-Holton E, Jee WS 1980 Cosmos 1129: spaceflight and bone changes. Physiologist 23:S79-S82
10. Turner RT, Bell NH, Duvall P, Bobyn JD, Spector M, Holton EM, Baylink DJ 1985 Spaceflight results in formation of defective bone. Proc Soc Exp Biol Med 180:544-549
11. Turner RT 1995 Effects of short term spaceflight and recombinant human growth hormone (rhGH) on bone in young rats. Aviat Space Environ Med 66:163-169
12. Cann CE, Adachi RR 1983 Bone resorption and mineral excretion in rats during spaceflight. Am J Physiol 244:R327-R331
13. Golbus RK, Bickle DD, Morey-Holton E 1986 The temporal response of bone to unloading. Endocrinology 118:733-742
14. Li XJ, Jee WS, Chow SY, Woodbury DM 1990 Adaption of cancellous bone-to aging and immobilization in the rat: a single photon absorptiometry and histomorphametry study. Anat Rec 227:12-24
15. Turner RT, Bell NH 1986 The effects of immobilization on bone histomorphometry in rats. J Bone Miner Res 1:399-407
16. Lin BY, Jee WS, Chen MM, Ma YF, Ke HZ, Li XJ 1994 Mechanical loading modifies ovariectomy-induced cancellous bone loss. Bone Miner 25:199-210
17. Thompson DP, Rodan GA 1988 Indomethacin inhibition of tenotomy-induced bone resorption in rats. J Bone Miner Res 3:409-414
18. Turner RT, Riggs BL, Spelsberg TC 1994 Skeletal effects of estrogen. Endocr Rev 15:275-300
19. Turner RT, Vandersteenhoven JJ, Bell NH 1987 The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 2:115-122
20. Wronski TJ, Cintron M, Dann LM 1988 Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43:179-183
21. Parfitt AM 1979 Quantum concepts of bone remodeling and turnover: implications for the pathogenesis of osteoporosis. Calcif Tissue Int 28:1-5
22. Westerlind KC, Jimenez M, Wronski TJ, Luo ZP, An KN, Bell NH, Turner RT, Estrogen regulates the rate of bone turnover but bone balance is determined by mechanical strain. Transactions of 41st Annual Meeting, Orthopaedic Research Society, p 235. Orlando, FL, 1995 (Abstract)
23. Bagi CM, Miller SC 1994 Comparison of osteopenic changes in cancellous bone induced by ovariectomy and/or immobilization in adult rats. Anat Rec 239:243-254
24. Turner RT, Backup P, Sherman PJ, Hill E, Evans GL, Spelsberg TC 1992 Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity. Endocrinology 131:883-889
25. Westerlind KC, Turner RT 1996 The skeletal effects of spaceflight in growing rats: tissue-specific alterations in mRNA levels for TGF-β. J Bone Miner Res 10:843-848
26. Evans GL, Bryant HU, Magee D, Sato M, Turner RT 1994 The effects of raloxitene on tibia histomorphometry in ovariectomized rats. Endocrinology 134:2283-2288
27. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, volume and thickness of iliac trabecular bone in aging and osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396-1409
28. Turner RT, Evans GL, Wakley GK 1993 Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: inhibition of indices of formation and resorption. J Bone Miner Res 8:359-366
29. Chomczynski P, Sacchi N 1987 Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
30. Celeste AL, Rosen V, Buecker JL, Kritz R, Wang EA, Wozney IM 1986 Isolation of the human gene for the bone gla protein utilizing mouse and rat cDNA clones. EMBO J 5:1885-1890
31. 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry 2:6210-6216
32. Wronski TJ, Dann LM, Scott KS, Cintron M 1989 Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366
33. Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA 1985 Skeletal alterations in ovariectomized rats. Calcif Tissue Int 37:324-328
34. Turner RT, Hannon KS, Demeres LM, Buchanan J, Bell NH 1989 Differential effects of gonadal function on bone histomorphometry in male and female rats. J Bone Miner Res 4:557-563
35. Li M, Wronski TJ 1995 Response of femoral neck to estrogen depletion and parathyroid hormone in aged rats. Bone 16:551-557
36. Westerlind KC, Wronski TJ, Evans GL, Turner RT 1994 The effects of long-term ovarian hormone deficiency on transforming growth factor-β and bone matrix protein mRNA expression in rat femora. Biochem Biophys Res Commun 200:283-289
37. Ikeda T, Shigeno C, Kasai R, Kohno H, Ohta S, Okumura H, Konishi J, Yamamuro T 1993 Ovariectomy decreases the mRNA levels of transforming growth factor-beta 1 and increases the mRNA levels of osteocalcin in rat bone in vivo. Biochem Biophys Res Commun 194:1228-1233
38. Finkelman RD, Bell NH, Strong DD, Demers LM, Baylink DJ 1992 Ovariectomy selectively reduces the concentration of transofrming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss. Proc Natl Acad Sci USA 89:12190-12193
39. Barengolts EI, Kouznetsova T, Segalene A, Lathon P, Odvina C, Kukreja SC, Unterman TG 1996 Effects of progesterone on serum levels of IGF-I and on femur IGF-I mRNA in ovariectomized rats. J Bone Miner Res 11:1406-1412
40. Raab-Cullen DM, Thiede MA, Petersen DN, Kimmel DB, Recker RR 1994 Mechanical loading stimulates rapid changes in periosteal gene expression. Calcif Tissue Int 55:473-478
41. Bikle DD, Harris J, Halloran BP, Morey-Holton E 1994 Skeletal unloading induces resistance to insulin like growth factor 1. J Bone Miner Res 9:1789-1796
42. Lean JM, Jagger CJ, Chambers TJ, Chow JWM 1995 Increased insulin-like growth factor 1 mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 268:E318-E327
43. Backup P, Westerlind K, Harris S, Spelsberg T, Kline B, Turner RT 1994 Spaceflight results in reduced mRNA levels for tissue-specific proteins in the musculoskeletal system. Am J Physiol 266:E567-E573
44. Wakley GK, Portwood JS, Turner RT 1992 Disuse osteoponia is accompanied by downregulation of gene expression for bone proteins in growing rats. Am J Physiol 263:E1029-E1034
45. Turner RT 1994 Cancellous bone turnover in growing rats: time dependent changes in association between calcein label and osteoblasts. J Bone Miner Res 9:1419-1424
46. Navidi M, Wolinsky I, Fung P, Arnavd SB 1995 Effects of excess dietary salt on calcium metabolism and bone mineral in a spaceflight model. J Appl Physiol 78:70-75
47. Tuukkanen J, Peng Z, Vaananen HK 1991 Effects of exercise on osteoporosis induced by ovariectomy in rats. Calcif Tissue Int 49:S80(Abstract)
48. Hymer WC, Grindeland R, Krasnov I, Victorov I, Matter K, Mukherjee P, Shellenberger K, Vasques M 1992 Effects of spaceflight on rat pituitary cell function. J Appl Physiol 73:151S-157S
49. Morrison DR, Chapes SK, Guikema JA, Spooner BS, Lewis ML 1992 Experiments with suspended cells on the space shuttle. Physiologist 35:S31-S34 (Review)
50. Cronin M, Battersby J, Hancock W, Schwall R, Clark R 1992 Delivery of recombinant human growth hormone during exposure to microgravity on NASA space shuttle Discovery. Physiologist 35:S51-S52
51. Amann RP, Deaver DR, Zirkin BR, Grills GS, Sapp WJ, Veeramacherti DN, Clemens JW, Banerjee SD, Folmer J, Gruppi CM, Wolgemuth DJ, Williams S 1992 Effects of microgravity or simulated launch on testicular function. J Appl Physiol 73:174S-185S
52. Rubin CT, Gross TS, McLeod KJ, Bain SD 1995 Morphological stages in lamellar bone formation stimulated by potent mechanical stimulus. J Bone Miner Res 10:488-495
53. Keila S, Pitaru S, Grosskopf A, Weinreb M 1994 Bone marrow from mechanically unloaded rat bones express reduced osteogenic capacity in vitro. J Bone Miner Res 9:321-327
54. Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E 1995 The molecular response of bone to growth hormone during skeletal unloading regional differences. Endocrinology 136:2099-2109
55. Simmons DJ, Grynpas MD, Rosenberg GD 1990 Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887. FASEB J 4:29-33
56. Simmons DJ, Russell JE, Gynpas MD 1986 Bone maturation and quality of bone material in rats flown on the space shuttle "Spncelab-3 Mission." Bone Miner 1:485-493
57. Simmons DJ, Russell JE, Winter F, Tran Van P, Vignery A, Baron R, Rosenberg GD, Walker WV 1983 Effects of spaceflight on the non-weight bearing bones of rat skeleton. Am J Physiol 244:R319-R326