Effect of antiandrogens casodex and epitestosterone on bone composition in mice

Bone

Volumn 20, Issue 5, 1997, Pages 473-475

  Broulik, P D ^a   Starka L ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Antiandrogens; Bone density; Bone mineral content; Casodex; Epitestosterone

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; BICALUTAMIDE; CALCIUM ION; EPITESTOSTERONE; ESTROGEN; LUTEINIZING HORMONE; PHOSPHATE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AROMATIZATION; ARTICLE; BONE DENSITY; BONE MINERAL; BONE STRUCTURE; CALCIUM BLOOD LEVEL; CALCIUM BONE LEVEL; CONTROLLED STUDY; FEMUR; INTRAPERITONEAL DRUG ADMINISTRATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; RECEPTOR BLOCKING; SEMINAL VESICLE; TESTOSTERONE BLOOD LEVEL;

ANDROGEN ANTAGONISTS; ANILIDES; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; EPITESTOSTERONE; HUMANS; LUTEINIZING HORMONE; MALE; MICE; ORCHIECTOMY; ORGAN SIZE; PHOSPHATES; RISK FACTORS; SEMINAL VESICLES; TESTIS; TESTOSTERONE;

EID: 0342617647     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00012-4     Document Type: Article

References (21)

1. Broulik, P. D. and Stárka, L. Effect of antiandrogen cyproterone acetate on the action of testosterone on bone protein. Endocr Exp 10:211-216; 1976.
2. Colvard, D. S., Eriksen, E. P., Keeting, P. E., Wilson, E. M., Lubahn, D. B., French, F. S., Riggs, B. L., and Spelberg, T. C. Identification of androgen receptors in normal human osteoblast-line cells. Proc Natl Acad Sci USA 86:854-857; 1989.
3. Danielsen, C. C., Mosekilde, L., and Andreassen, T. T. Long-term effect of orchidectomy on cortical bone from rat femur bone mass and mechanical properties. Calcif Tissue Int 50:169-174; 1992.
4. Duncan, D. Multiple range and multiple F tests. Biometrics 11:1-4; 1955.
5. Freeman, S. N., Mainwaring, W. I. P., and Furr, B. J. A. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176, 334). Br J Cancer 60:664-668; 1989.
6. Furr, B. J. A. and Tucker, H. The preclinical development of bicalutamide: Pharmacodynamics and mechanism of action. Urology 47:13-25; 1996.
7. Gittelman, H. J. An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem 18:521-531; 1967.
8. Hampl, R., Dvořák, P., Lukešová, S., Kozák, I., Chrpová, M., and Stárka, L. The use of iodinated steroid as radioligand for testosterone radioimmunoassay. J Steroid Biochem 9:771-773; 1978.
9. Hertel, P., Kramer, M., and Neumann, F. Einfluss eines antiandrogen (Cyproteroacetate) auf Knochenwachstum mannlicher ratten. Arzeneimittel-Forschung 11:1777-1789; 1969.
10. Iversen, P., Tveter, K., and Varenhorts, E. Results of a Scandinavian multi-centre open phase III study of casodex versus orchidectomy in the treatment of metastatic prostate cancer. In. Murphy, G., Khoury, S., Chatelain, C., and Denis, L., Eds. Proceedings of the third international symposium on Recent Advances in Urologic Cancer. Diagnosis and treatment. Paris: Zeneca; 1992; 120-125.
11. Kalu, D. N., Hardin, R. R., and Cockerham, R. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology 115:507-511; 1994.
12. Kraml, J. A semiautomated determination of phospholipids. Clin Chim Acta 13:442-448; 1966.
13. Maucher, A., Kager, M., and von Angerer, E. Evaluation of the antitumor activity of coumarin in prostate cancer model. J Cancer Res Clin Oncol 119: 150-154; 1993.
14. Nuck, B. A. and Lucky, A. W. Epitestosterone: A potentional new antiandrogen. J Invest Dermatol 89:209-211; 1987.
15. Rosen, H. N., Tollin, S., Balena, R., Middlebrooks, V. L., Moses, A. C., Yamamoto, M., Zeind, A. J., and Greenspan, S. L. Bone density is normal in male rats treated with finasteride. Endocrinology 136:1381-1387; 1995.
16. Schweikert, H. U., Ruef, W., Niederle, N., Schafer, H. E., Keck, E., and Kruek, F. Testosterone metabolism in human bone. Acta Endocrinol Copenh 95:254-264; 1980.
17. Smith, E., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., and Korach, K. S. Estrogen resistance caused by a mutation in the estrogen receptor gene in a man. N Engl J Med 331: 1056-1061; 1994.
18. Stárka, L. Epitestosterone-a antihormone or not? Endocr Regul 27:43-48; 1993.
19. Stárka, L., Bičiková, M., and Hampl, R. Epitestosterone - an endogenous antiandrogen. J Steroid Biochem 33:1019-1020; 1989.
20. Verhelst, J., Denis, L., Van vliet, P., Van Popel, H., Braeckman, J., van Cangh, P., Mattelaer, J., Hulster, D., and Mahler, C. Endocrine profiles during administration of the new non-steroidal anti-androgen casodex in prostate cancer. Clin Endocr 41:525-530; 1994.
21. Wink, C. S. and Felts, W. J. L. Effects of castration on the new bone structure of male rats: A model of osteoporosis. Calcif Tissue Int 32:77-82; 1980.