Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 2 37-2, 1998, Pages

  Lea, C K ^a   Flanagan, A M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Androstenedione; Arimidex; Bone formation; Bone resorption; Estrogen

Indexed keywords

ANASTROZOLE; ANDROGEN; ANDROSTENEDIONE; BICALUTAMIDE; TESTOSTERONE;

ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCELLOUS BONE; CONTROLLED STUDY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; OSTEOPENIA; OVARIECTOMY; PRIORITY JOURNAL; RAT; TESTOSTERONE BLOOD LEVEL; TIBIA;

EID: 0031888868     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.2.e328     Document Type: Article

References (29)

1. Buchanan, J. R., P. Hospodar, C. Myers, P. Leuenberger, and L. M. Demers. The effect of excess endogenous androgens on bone density in young women. J. Clin. Endocrinol. Metab. 67: 937-943, 1988.
2. Chesnut, C. H., J. L. Iven, H. E. Gruber, M. Mathews, W. B. Nelp, K. Sisom, and D. J. Baylink. Stanozolol in postmenopausal osteoporosis: therapeutic efficacy and possible mechanism of action. Metabolism 32: 571-580, 1983.
3. Christiansen, C., M. S. Christiansen, N.-E. Larsen, and I. Transbol. Pathophysiological mechanism of estrogen effect on bone metabolism: dose-response relationship in early postmenopausal women. J. Clin. Endocrinol. Metab. 55: 1124-1130, 1982.
4. Christiansen, C., B. J. Riis, and P. Rodbro. Prediction of rapid bone loss in postmenopausal women. Lancet 1: 1105-1108, 1987.
5. Colvard, D. S. E., E. F. Eriksen, P. E. Keeting, E. M. Wilson, D. B. Lubahn, F. S. French, B. L. Riggs, and T. C. Spelsberg. Identification of androgen receptors in normal human osteoblast-like cells. Proc. Natl. Acad. Sci. USA 86: 854-857, 1989.
6. Dixon, J. E., A. Rodin, B. Murby, M. G. Chapman, and I. Fogelman. Bone mass in hirsute women with androgen excess. Clin. Endocrinol. 30: 271-277, 1989.
7. Furr, B. J. A. Casodex (ICI 176 334) - a new, pure, peripherally-selective antiandrogen: preclinical studies. Horm. Res. 32: 69-76, 1989.
8. Gallagher, A., T. J. Chambers, and J. H. Tobias. The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats. Endocrinology 133: 2787-2791, 1993.
9. Gallagher, A. C., T. J. Chambers, and J. H. Tobias. Androgens contribute to the stimulation of cancellous bone formation by ovarian hormones in female rats. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E407-E412, 1996.
10. Garnero, P., E. Hausherr, M. C. Chapuy, C. Marcelli, H. Grandjean, C. Muller, C. Cormier, G. Breart, P. J. Meunier, and P. D. Delmas. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J. Bone Miner. Res. 11: 1531-1538, 1996.
11. Judd, H. L., and N. Fournet. Changes of ovarian hormonal function with aging. Exp. Gerontol. 29: 285-298, 1994.
12. Kalu, D. N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15: 175-192, 1991.
13. Kalu, D. N., C.-C. Liu, R. R. Hardin, and B. W. Hollis. The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124: 7-16, 1989.
14. Lea, C., N. Kendall, and A. M. Flanagan. Casodex (a nonsteroidal antiandrogen) reduces cancellous, endosteal and periosteal bone formation in estrogen-replete female rats. Calcif. Tissue Int. 58: 268-272, 1996.
15. Lea, C. K., V. Moxham, M. J. Reed, and A. M. Flanagan. Androstenedione treatment reduces loss of cancellous bone volume in ovariectomised rats in a dose-responsive manner and the effect is not mediated by oestrogens. J. Endocrinol. 156: 331-339, 1998.
16. Lindsay, R., D. M. Hart, J. M. Aitken, E. B. MacDonald, J. B. Anderson, and A. C. Clarke. Long-term prevention of postmenopausal osteoporosis by estrogen. Lancet 1: 1038-1041, 1976.
17. Lips, P., and K. J. Obrant. The pathogenesis and treatment of hip fractures. Osteoporosis 1: 218-231, 1991.
18. Ott, S. M. Attainment of peak bone mass. J. Clin. Endocrinol. Metab. 71: 1082A-1082C, 1990.
19. Oursler, M. J., B. L. Riggs, and T. C. Spelsberg. Androgen action on avian osteoclasts and human giant cell tumours of the bone (Abstract). J. Bone Miner. Res. 8, Suppl. 1: S387, 1993.
20. Parfitt, A. M., C. H. E. Matthews, A. R. Villeneuve, and M. Kleerekoper. Relationships between surface, volume and thickness of iliac trabecular bone in ageing and in osteoporosis. J. Clin. Invest. 72: 1396-1409, 1983.
21. Plourde, P. V., M. Dyroff, and M. Dukes. Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res. Treat. 30: 103-111, 1994.
22. Richelson, L. S., H. W. Heinze, L. J. Melton III, and B. L. Riggs. Relative contributions of ageing and estrogen deficiency to postmenopausal bone loss. N. Engl. J. Med. 311: 1273-1275, 1984.
23. Tobias, J. H., A. Gallagher, and T. J. Chambers. 5α-Dihydrotestosterone partially restores cancellous bone volume in osteopenic ovariectomized rats. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E853-E859, 1994.
24. Turner, R. T., E. T. Lifrak, M. Beckner, G. K. Wakley, K. S. Hannon, and L. N. Parker. Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E673-E677, 1990.
25. Turner, R. T., J. J. Vandersteenhoven, and N. H. Bell. The effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats. J. Bone Miner. Res. 2: 115-122, 1987.
26. Vanderschueren, D., E. Van Herck, A. M. H. Suiker, W. J. Visser, L. P. C. Schot, and R. Bouillon. Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. Endocrinology 130: 2906-2916, 1992.
27. Wakley, G. K., H. D. Schutte, K. S. Hannon, and R. T. Turner. Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J. Bone Miner. Res. 6: 325-329, 1991.
28. Wronski, T. J., M. Cintron, and L. M. Dann. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif. Tissue Int. 43: 179-183, 1988.
29. Wronski, T. J., M. Cintron, A. L. Doherty, and L. M. Dann. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123: 681-686, 1988.