Apoptotic cell death in TrkA-overexpressing cells: Kinetic regulation of ERK phosphorylation and caspase-7 activation

Molecules and Cells

Volumn 26, Issue 1, 2008, Pages 12-17

  Jung, Eun Joo ^a   Kim, Deok Ryong ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Apoptotic cell death; Bax; Caspase 7; Colony formation; ERK; NGF; TrkA

Indexed keywords

CASPASE 7; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P18; PROTEIN TYROSINE KINASE A;

APOPTOSIS; ARTICLE; BINDING ASSAY; CELL FATE; CELL LINE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEGRADATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR MECHANICS; NERVE CELL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; BONE TUMOR; CELL CULTURE; CELL CYCLE G1 PHASE; CLONOGENIC ASSAY; DRUG EFFECT; KINETICS; METABOLISM; NEUROBLASTOMA; OSTEOSARCOMA; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BONE NEOPLASMS; CASPASE 7; COLONY-FORMING UNITS ASSAY; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; G1 PHASE; HUMANS; KINETICS; NERVE GROWTH FACTOR; NEUROBLASTOMA; OSTEOSARCOMA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, TRKA; TUMOR CELLS, CULTURED;

EID: 53449083469     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Cartron, P.F., Oliver, L., Juin, P., Meflah, K., and Vallette, F.M. (2004). The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein. J. Biol. Chem. 279, 11503-11512.
2. Chou, T.T., Trojanowski, J.Q., and Lee, V.M. (2000). A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma. J. Biol. Chem. 275, 565-570.
3. Costantini, C., Scrable, H., and Puglielli, L. (2006). An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. EMBO J. 25, 1997-2006.
4. Cowley, S., Paterson, H., Kemp, P., and Marshall, C.J. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
5. Friedman, W.J., and Greene, L.A. (1999). Neurotrophin signaling via Trks and p75. Exp. Cell. Res. 253, 131-142.
6. Jung, E.J., and Flemington, E.K. (2001). Transfection-mediated cell synchronization: acceleration of G1-S phase transition by gamma irradiation. BioTechniques 31, 1026, 1028, 1031-1024.
7. Klein, R., Jing, S.Q., Nanduri, V., O'Rourke, E., and Barbacid, M. (1991). The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189-197.
8. Kurz, E.U., and Lees-Miller, S.P. (2004). DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair 3, 889-900.
9. Kurz, E.U., Douglas, P., and Lees-Miller, S.P. (2004). Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J. Biol. Chem. 279, 53272-53281.
10. Marshall, C.J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
11. Muragaki, Y., Chou, T.T., Kaplan, D.R., Trojanowski, J.Q., and Lee, V.M. (1997). Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. J. Neurosci. 17, 530-542.
12. Reichardt, L.F. (2006). Neurotrophin-regulated signalling pathways. Phil. Trans. R. Soc. B. 361, 1545-1564.
13. Rong, J., McGuire, J.R., Fang, Z.H., Sheng, G., Shin, J.Y., Li, S.H., and Li, X.J. (2006). Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J. Neurosci. 26, 6019-6030.
14. Schramm, A., Schulte, J.H., Astrahantseff, K., Apostolov, O., Limpt, V., Sieverts, H., Kuhfittig-Kulle, S., Pfeiffer, P., Versteeg, R., and Eggert, A. (2005). Biological effects of TrkA and TrkB receptor signaling in neuroblastoma. Cancer Lett. 228, 143-153.
15. Shikata, A., Shikata, T., Sotozono, Y., Hosoi, H., Matsumura, T., Sugimoto, T., and Sawada, T. (2000). Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma. Med. Pediatr. Oncol. 34, 394-401.
16. Shim, H.Y., Park, J.H., Paik, H.D., Nah, S.Y., Kim, D.S., and Han, Y.S. (2007). Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/ JNK1/2-c-Jun activation. Mol. Cells 24, 95-104.
17. Stephens, R.M., Loeb, D.M., Copeland, T.D., Pawson, T., Greene, L.A., and Kaplan, D.R. (1994). Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12, 691-705.
18. Tacconelli, A., Farina, A.R., Cappabianca, L., Desantis, G., Tessitore, A., Vetuschi, A., Sferra, R., Rucci, N., Argenti, B., Screpanti, I., et al. (2004). TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6, 347-360.
19. Tang, D., Wu, D., Hirao, A., Lahti, J.M., Liu, L., Mazza, B., Kidd, V.J., Mak, T.W., and Ingram, A.J. (2002). ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 277, 12710-12717.
20. Toyota, H., Yanase, N., Yoshimoto, T., Moriyama, M., Sudo, T., and Mizuguchi, J. (2003). Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer Lett. 189, 221-230.
21. Urra, S., Escudero, C.A., Ramos, P., Lisbona, F., Allende, E., Covarrubias, P., Parraguez, J.I., Zampieri, N., Chao, M.V., Annaert, W., et al. (2007). TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J. Biol. Chem. 282, 7606-7615.
22. Woessmann, W., Chen, X., and Borkhardt, A. (2002). Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemother. Pharmacol. 50, 397-404.
23. Wood, D.E., Thomas, A., Devi, L.A., Berman, Y., Beavis, R.C., Reed, J.C., and Newcomb, E.W. (1998). Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene 17, 1069-1078.
24. Yan, C., Liang, Y., Nylander, K.D., and Schor, N.F. (2002). TrkA as a life and death receptor: receptor dose as a mediator of function. Cancer Res. 62, 4867-4875.