Indole amide derivatives: Synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H1-receptor antagonists

European Journal of Medicinal Chemistry

Volumn 34, Issue 2, 1999, Pages 93-105

  Battaglia, Sandra ^a   Boldrini, Enrico ^b   Da Settimo, Federico ^a   Dondio, Giulio ^c   La Motta, Concettina ^a   Marini, Anna Maria ^a   Primofiore, Giampaolo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Farmigea SpA   (Italy)

^c SmithKline Beecham   (Italy)

Author keywords

Astemizole; Indole derivatives; Non classic H1 antagonists; Structure activity relationships

Indexed keywords

AMIDE; ASTEMIZOLE; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; INDOLE DERIVATIVE; MEPYRAMINE; N (1 BENZYL 3 INDOLECARBONYL) 2 DIMETHYLAMINOETHYLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GUINEA PIG; MALE; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032742725     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80044-0     Document Type: Article

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