5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5541-5544

  Winters, Michael P ^b   Robinson, Darius J ^b   Khine, Hnin Hnin ^a   Pullen, Steven S ^a   Woska Jr , Joseph R ^a   Raymond, Ernest L ^a   Sellati, Rosemarie ^a   Cywin, Charles L ^a   Snow, Roger J ^a   Kashem, Mohammed A ^a   Wolak, John P ^a   King, Josephine ^a   Kaplita, Paul V ^a   Liu, Lisa H ^a   Farrell, Thomas M ^a   DesJarlais, Renee ^b   Roth, Gregory P ^c   Takahashi, Hidenori ^a   Moriarty, Kevin J ^b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c Burnham Institute for Medical Research at Lake Nona   (United States)

Author keywords

Benzimidazole; In vivo mouse model; Itk inhibitor; SAR

Indexed keywords

5 AMINOMETHYL 1H BENZIMIDAZOLE; BENZIMIDAZOLE; INDUCIBLE T CELL KINASE; INTERLEUKIN 2; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CYTOKINE PRODUCTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD3; BENZIMIDAZOLES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MODELS, CHEMICAL; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

MUS;

EID: 53349165531     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.016     Document Type: Article

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