메뉴 건너뛰기




Volumn 322, Issue 2, 2008, Pages 314-321

Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number

Author keywords

Atrium; Chamber morphogenesis; Heart development; Heart tube assembly; nkx2.5; nkx2.7; Ventricle; Zebrafish

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR NKX2.7; UNCLASSIFIED DRUG;

EID: 53249113134     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.07.037     Document Type: Article
Times cited : (80)

References (48)
  • 1
    • 0031805094 scopus 로고    scopus 로고
    • Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning
    • Alexander J., et al. Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Dev. Genet. 22 (1998) 288-299
    • (1998) Dev. Genet. , vol.22 , pp. 288-299
    • Alexander, J.1
  • 2
    • 33750004852 scopus 로고    scopus 로고
    • Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart
    • Allen B.G., et al. Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech. Dev. 123 (2006) 719-729
    • (2006) Mech. Dev. , vol.123 , pp. 719-729
    • Allen, B.G.1
  • 3
    • 0027237596 scopus 로고
    • tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
    • Azpiazu N., and Frasch M. tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7 (1993) 1325-1340
    • (1993) Genes Dev. , vol.7 , pp. 1325-1340
    • Azpiazu, N.1    Frasch, M.2
  • 4
    • 0034710920 scopus 로고    scopus 로고
    • Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral
    • Baird G.S., et al. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 11984-11989
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11984-11989
    • Baird, G.S.1
  • 5
    • 34548818514 scopus 로고    scopus 로고
    • Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis
    • Bartlett H.L., et al. Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis. Dev. Dyn. 236 (2007) 2475-2484
    • (2007) Dev. Dyn. , vol.236 , pp. 2475-2484
    • Bartlett, H.L.1
  • 6
    • 0033430230 scopus 로고    scopus 로고
    • Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
    • Benson D.W., et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J. Clin. Invest. 104 (1999) 1567-1573
    • (1999) J. Clin. Invest. , vol.104 , pp. 1567-1573
    • Benson, D.W.1
  • 7
    • 0346602694 scopus 로고    scopus 로고
    • Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    • Berdougo E., et al. Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130 (2003) 6121-6129
    • (2003) Development , vol.130 , pp. 6121-6129
    • Berdougo, E.1
  • 8
    • 0036138545 scopus 로고    scopus 로고
    • Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed)
    • Bevis B.J., and Glick B.S. Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed). Nat. Biotechnol. 20 (2002) 83-87
    • (2002) Nat. Biotechnol. , vol.20 , pp. 83-87
    • Bevis, B.J.1    Glick, B.S.2
  • 9
    • 0034634279 scopus 로고    scopus 로고
    • Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5
    • Biben C., et al. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Circ. Res. 87 (2000) 888-895
    • (2000) Circ. Res. , vol.87 , pp. 888-895
    • Biben, C.1
  • 10
    • 0032796828 scopus 로고    scopus 로고
    • Regulation of midline development by antagonism of lefty and nodal signaling
    • Bisgrove B.W., et al. Regulation of midline development by antagonism of lefty and nodal signaling. Development 126 (1999) 3253-3262
    • (1999) Development , vol.126 , pp. 3253-3262
    • Bisgrove, B.W.1
  • 11
    • 0027282774 scopus 로고
    • The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    • Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118 (1993) 719-729
    • (1993) Development , vol.118 , pp. 719-729
    • Bodmer, R.1
  • 12
    • 39749191367 scopus 로고    scopus 로고
    • The developmental genetics of congenital heart disease
    • Bruneau B.G. The developmental genetics of congenital heart disease. Nature 451 (2008) 943-948
    • (2008) Nature , vol.451 , pp. 943-948
    • Bruneau, B.G.1
  • 13
    • 33644680809 scopus 로고    scopus 로고
    • Building the mammalian heart from two sources of myocardial cells
    • Buckingham M., et al. Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 6 (2005) 826-835
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 826-835
    • Buckingham, M.1
  • 14
    • 0030465318 scopus 로고    scopus 로고
    • Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
    • Chen J.N., and Fishman M.C. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122 (1996) 3809-3816
    • (1996) Development , vol.122 , pp. 3809-3816
    • Chen, J.N.1    Fishman, M.C.2
  • 15
    • 0034904642 scopus 로고    scopus 로고
    • Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown
    • Draper B.W., et al. Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown. Genesis 30 (2001) 154-156
    • (2001) Genesis , vol.30 , pp. 154-156
    • Draper, B.W.1
  • 16
    • 0037975739 scopus 로고    scopus 로고
    • Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome
    • Elliott D.A., et al. Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J. Am. Coll. Cardiol. 41 (2003) 2072-2076
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 2072-2076
    • Elliott, D.A.1
  • 17
    • 0028863326 scopus 로고
    • tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman
    • Evans S.M., et al. tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development 121 (1995) 3889-3899
    • (1995) Development , vol.121 , pp. 3889-3899
    • Evans, S.M.1
  • 18
    • 0036920053 scopus 로고    scopus 로고
    • Cardiac development in zebrafish: coordination of form and function
    • Glickman N.S., and Yelon D. Cardiac development in zebrafish: coordination of form and function. Semin. Cell. Dev. Biol. 13 (2002) 507-513
    • (2002) Semin. Cell. Dev. Biol. , vol.13 , pp. 507-513
    • Glickman, N.S.1    Yelon, D.2
  • 19
    • 0032380010 scopus 로고    scopus 로고
    • Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5
    • Grow M.W., and Krieg P.A. Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev. Biol. 204 (1998) 187-196
    • (1998) Dev. Biol. , vol.204 , pp. 187-196
    • Grow, M.W.1    Krieg, P.A.2
  • 20
    • 0029000773 scopus 로고
    • Incidence of congenital heart disease: II. Prenatal incidence
    • Hoffman J.I. Incidence of congenital heart disease: II. Prenatal incidence. Pediatr. Cardiol. 16 (1995) 155-165
    • (1995) Pediatr. Cardiol. , vol.16 , pp. 155-165
    • Hoffman, J.I.1
  • 21
    • 0037134945 scopus 로고    scopus 로고
    • The incidence of congenital heart disease
    • Hoffman J.I., and Kaplan S. The incidence of congenital heart disease. J. Am. Coll. Cardiol. 39 (2002) 1890-1900
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 1890-1900
    • Hoffman, J.I.1    Kaplan, S.2
  • 22
    • 34347349136 scopus 로고    scopus 로고
    • Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    • Holtzman N.G., et al. Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development 134 (2007) 2379-2386
    • (2007) Development , vol.134 , pp. 2379-2386
    • Holtzman, N.G.1
  • 23
    • 0027184211 scopus 로고
    • Csx: a murine homeobox-containing gene specifically expressed in the developing heart
    • Komuro I., and Izumo S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 8145-8149
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 8145-8149
    • Komuro, I.1    Izumo, S.2
  • 24
    • 0030589617 scopus 로고    scopus 로고
    • A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm
    • Lee K.H., et al. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol. 180 (1996) 722-731
    • (1996) Dev. Biol. , vol.180 , pp. 722-731
    • Lee, K.H.1
  • 25
    • 33750483609 scopus 로고    scopus 로고
    • A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration
    • Lepilina A., et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127 (2006) 607-619
    • (2006) Cell , vol.127 , pp. 607-619
    • Lepilina, A.1
  • 26
    • 0027700251 scopus 로고
    • Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
    • Lints T.J., et al. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119 (1993) 419-431
    • (1993) Development , vol.119 , pp. 419-431
    • Lints, T.J.1
  • 27
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    • Lyons I., et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9 (1995) 1654-1666
    • (1995) Genes Dev. , vol.9 , pp. 1654-1666
    • Lyons, I.1
  • 28
    • 0346403347 scopus 로고    scopus 로고
    • heart of glass regulates the concentric growth of the heart in zebrafish
    • Mably J.D., et al. heart of glass regulates the concentric growth of the heart in zebrafish. Curr. Biol. 13 (2003) 2138-2147
    • (2003) Curr. Biol. , vol.13 , pp. 2138-2147
    • Mably, J.D.1
  • 29
    • 0242636701 scopus 로고    scopus 로고
    • NKX2.5 mutations in patients with congenital heart disease
    • McElhinney D.B., et al. NKX2.5 mutations in patients with congenital heart disease. J. Am. Coll. Cardiol. 42 (2003) 1650-1655
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 1650-1655
    • McElhinney, D.B.1
  • 30
    • 2342518098 scopus 로고    scopus 로고
    • The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    • Meilhac S.M., et al. The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev. Cell. 6 (2004) 685-698
    • (2004) Dev. Cell. , vol.6 , pp. 685-698
    • Meilhac, S.M.1
  • 31
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius A., and Ekker S.C. Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26 (2000) 216-220
    • (2000) Nat. Genet. , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 32
    • 0033994198 scopus 로고    scopus 로고
    • Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10
    • Newman C.S., et al. Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10. Mech. Dev. 91 (2000) 369-373
    • (2000) Mech. Dev. , vol.91 , pp. 369-373
    • Newman, C.S.1
  • 33
    • 0035992788 scopus 로고    scopus 로고
    • Developmental paradigms in heart disease: insights from tinman
    • Prall O.W., et al. Developmental paradigms in heart disease: insights from tinman. Ann. Med. 34 (2002) 148-156
    • (2002) Ann. Med. , vol.34 , pp. 148-156
    • Prall, O.W.1
  • 34
    • 33847344204 scopus 로고    scopus 로고
    • An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation
    • Prall O.W., et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 (2007) 947-959
    • (2007) Cell , vol.128 , pp. 947-959
    • Prall, O.W.1
  • 35
    • 31644435347 scopus 로고    scopus 로고
    • Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis
    • Rohr S., et al. Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Development 133 (2006) 107-115
    • (2006) Development , vol.133 , pp. 107-115
    • Rohr, S.1
  • 36
    • 41149099651 scopus 로고    scopus 로고
    • Asymmetric involution of the myocardial field drives heart tube formation in zebrafish
    • Rohr S., et al. Asymmetric involution of the myocardial field drives heart tube formation in zebrafish. Circ. Res. 102 (2008) e12-e19
    • (2008) Circ. Res. , vol.102
    • Rohr, S.1
  • 37
    • 34547482623 scopus 로고    scopus 로고
    • Vessel and blood specification override cardiac potential in anterior mesoderm
    • Schoenebeck J.J., et al. Vessel and blood specification override cardiac potential in anterior mesoderm. Dev. Cell. 13 (2007) 254-267
    • (2007) Dev. Cell. , vol.13 , pp. 254-267
    • Schoenebeck, J.J.1
  • 38
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • Schott J.J., et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281 (1998) 108-111
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1
  • 39
    • 0029583152 scopus 로고
    • Induction of avian cardiac myogenesis by anterior endoderm
    • Schultheiss T.M., et al. Induction of avian cardiac myogenesis by anterior endoderm. Development 121 (1995) 4203-4214
    • (1995) Development , vol.121 , pp. 4203-4214
    • Schultheiss, T.M.1
  • 40
    • 38849191869 scopus 로고    scopus 로고
    • Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells
    • Smith K.A., et al. Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell. 14 (2008) 287-297
    • (2008) Dev. Cell. , vol.14 , pp. 287-297
    • Smith, K.A.1
  • 41
    • 0027296431 scopus 로고
    • Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation
    • Stainier D.Y., et al. Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development 119 (1993) 31-40
    • (1993) Development , vol.119 , pp. 31-40
    • Stainier, D.Y.1
  • 42
    • 0036362978 scopus 로고    scopus 로고
    • Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a UTR-ires-Cre allele of the homeobox gene Nkx2-5
    • Stanley E.G., et al. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 46 (2002) 431-439
    • (2002) Int. J. Dev. Biol. , vol.46 , pp. 431-439
    • Stanley, E.G.1
  • 43
    • 0034967610 scopus 로고    scopus 로고
    • Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx
    • Tanaka M., et al. Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol. Cell. Biol. 21 (2001) 4391-4398
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4391-4398
    • Tanaka, M.1
  • 44
    • 0344428124 scopus 로고    scopus 로고
    • Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
    • Tanaka M., et al. Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5. Development 126 (1999) 1439-1450
    • (1999) Development , vol.126 , pp. 1439-1450
    • Tanaka, M.1
  • 45
    • 0034115494 scopus 로고    scopus 로고
    • Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting
    • Tanaka M., et al. Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol. Cell. Biol. 20 (2000) 2874-2879
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2874-2879
    • Tanaka, M.1
  • 46
    • 0030273436 scopus 로고    scopus 로고
    • Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos
    • Ticho B.S., et al. Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. Mech. Dev. 59 (1996) 205-218
    • (1996) Mech. Dev. , vol.59 , pp. 205-218
    • Ticho, B.S.1
  • 47
    • 0028294694 scopus 로고
    • XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development
    • Tonissen K.F., et al. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev. Biol. 162 (1994) 325-328
    • (1994) Dev. Biol. , vol.162 , pp. 325-328
    • Tonissen, K.F.1
  • 48
    • 0033215267 scopus 로고    scopus 로고
    • Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish
    • Yelon D., et al. Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Dev. Biol. 214 (1999) 23-37
    • (1999) Dev. Biol. , vol.214 , pp. 23-37
    • Yelon, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.