Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenovus laevis

Developmental Dynamics

Volumn 236, Issue 9, 2007, Pages 2475-2484

  Bartlett, Heather L ^a   Sutherland, Lillian ^a,b   Kolker, Sandra J ^a,c   Welp, Chelsea ^a   Tajchman, Urszula ^a,d   Desmarais, Vera ^a,e   Weeks, Daniel L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d Bend Memorial Clinic   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Heart development; Nkx2 5; Xenopus

Indexed keywords

HOMEODOMAIN PROTEIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR NKX2.5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CANAL; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DISEASE SEVERITY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC CONSERVATION; HEART ATRIUM SEPTUM; HEART CONTRACTION; HEART DEVELOPMENT; HEART MUSCLE CONDUCTION DISTURBANCE; HOMOZYGOSITY; MALE; NKX2 5 GENE; NONHUMAN; PRIORITY JOURNAL; TINMAN GENE; XENOPUS LAEVIS;

ANIMALS; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; HOMEODOMAIN PROTEINS; HOMOZYGOTE; HUMANS; MICROSCOPY, VIDEO; MODELS, GENETIC; MUTATION; MYOCARDIAL CONTRACTION; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

MUS;

EID: 34548818514     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21244     Document Type: Article

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