Activation of the μ opioid receptor involves conformational rearrangements of multiple transmembrane domains

Biochemistry

Volumn 47, Issue 40, 2008, Pages 10576-10586

  Xu, Wei ^a   Sanz, Arantxa ^b   Pardo, Leonardo ^b   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BINDING SITES; CELL MEMBRANES;

CONFORMATIONAL CHANGES; CONFORMATIONAL REARRANGEMENTS; METHANETHIOSULFONATE-ETHYLAMMONIUM; RECEPTOR ACTIVATION; TRANS-MEMBRANE DOMAINS;

YTTRIUM ALLOYS;

AMMONIUM DERIVATIVE; BETA 2 ADRENERGIC RECEPTOR; DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; METHANETHIOSULFONATE ETHYLAMMONIUM; MU OPIATE RECEPTOR; MUTANT PROTEIN; NALOXONE; OPSIN; RHODOPSIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CELL STRAIN HEK293; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DIPRENORPHINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, OPIOID, MU;

RATTUS;

EID: 53249111444     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800381v     Document Type: Article

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