Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion

Biochemical and Biophysical Research Communications

Volumn 376, Issue 3, 2008, Pages 558-562

  Larsson, Sara ^a   Wierup, Nils ^a   Sundler, Frank ^a   Eliasson, Lena ^b   Holm, Cecilia ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cells; Cholesterol; Hormone sensitive lipase; Insulin secretion; Methyl cyclodextrin

Indexed keywords

ABC TRANSPORTER A1; CAVEOLIN 1; CHOLESTEROL; CHOLESTEROL ESTERASE; HORMONE SENSITIVE LIPASE; METHYL BETA CYCLODEXTRIN; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXOCYTOSIS; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; MORPHOMETRICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; BETA-CYCLODEXTRINS; CATIONIC AMINO ACID TRANSPORTER 1; CELL MEMBRANE; CHOLESTEROL; EXOCYTOSIS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; STEROL ESTERASE; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

MUS;

EID: 53149125096     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.09.045     Document Type: Article

References (26)

1. Mulder H., Holst L.S., Svensson H., Degerman E., Sundler F., Ahren B., Rorsman P., and Holm C. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells. Diabetes 48 (1999) 228-232
2. Lindvall H., Nevsten P., Strom K., Wallenberg R., Sundler F., Langin D., Winzell M.S., and Holm C. A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells. J. Biol. Chem. 279 (2004) 3828-3836
3. Fex M., Olofsson C.S., Fransson U., Bacos K., Lindvall H., Sorhede-Winzell M., Rorsman P., Holm C., and Mulder H. Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact. Endocrinology 145 (2004) 3746-3753
4. Orci L., Amherdt M., Montesano R., Vassalli P., and Perrelet A. Topology of morphologically detectable protein and cholesterol in membranes of polypeptide-secreting cells. Philos. Trans. R. Soc. Lond. B Biol. Sci. 296 (1981) 47-54
5. Lang T., Bruns D., Wenzel D., Riedel D., Holroyd P., Thiele C., and Jahn R. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. EMBO J. 20 (2001) 2202-2213
6. Flamez D., Berger V., Kruhoffer M., Orntoft T., Pipeleers D., and Schuit F.C. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes 51 (2002) 2018-2024
7. Macdonald M.J., Dobrzyn A., Ntambi J., and Stoker S.W. The role of rapid lipogenesis in insulin secretion: insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Arch. Biochem. Biophys. 470 (2008) 153-162
8. Nevins A.K., and Thurmond D.C. A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. J. Biol. Chem. 280 (2005) 1944-1952
9. Kowluru A., Seavey S.E., Li G., Sorenson R.L., Weinhaus A.J., Nesher R., Rabaglia M.E., Vadakekalam J., and Metz S.A. Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. J. Clin. Invest. 98 (1996) 540-555
10. Gingras D., Gauthier F., Lamy S., Desrosiers R.R., and Beliveau R. Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains. Biochem. Biophys. Res. Commun. 247 (1998) 888-893
11. Xia F., Gao X., Kwan E., Lam P.P., Chan L., Sy K., Sheu L., Wheeler M.B., Gaisano H.Y., and Tsushima R.G. Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J. Biol. Chem. 279 (2004) 24685-24691
12. Chen H.Q., Tannous M., Veluthakal R., Amin R., and Kowluru A. Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. Biochem. Pharmacol. 66 (2003) 1681-1694
13. Veluthakal R., Chvyrkova I., Tannous M., McDonald P., Amin R., Hadden T., Thurmond D.C., Quon M.J., and Kowluru A. Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+. Diabetes 54 (2005) 2576-2585
14. Chamberlain L.H., Burgoyne R.D., and Gould G.W. SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc. Natl. Acad. Sci. USA 98 (2001) 5619-5624
15. Nevins A.K., and Thurmond D.C. Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells. J. Biol. Chem. 281 (2006) 18961-18972
16. Brunham L.R., Kruit J.K., Pape T.D., Timmins J.M., Reuwer A.Q., Vasanji Z., Marsh B.J., Rodrigues B., Johnson J.D., Parks J.S., Verchere C.B., and Hayden M.R. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13 (2007) 340-347
17. Talts J.F., Brakebusch C., and Fassler R. Integrin gene targeting. Methods Mol. Biol. 129 (1999) 153-187
18. Grober J., Lucas S., Sorhede-Winzell M., Zaghini I., Mairal A., Contreras J.A., Besnard P., Holm C., and Langin D. Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. J. Biol. Chem. 278 (2003) 6510-6515
19. Gamble W., Vaughan M., Kruth H.S., and Avigan J. Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J. Lipid Res. 19 (1978) 1068-1070
20. Wierup N., Richards W.G., Bannon A.W., Kuhar M.J., Ahren B., and Sundler F. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul. Pept. 129 (2005) 203-211
21. Vikman J., Ma X., Hockerman G.H., Rorsman P., and Eliasson L. Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells. J. Mol. Endocrinol. 36 (2006) 503-515
22. Ohara-Imaizumi M., Nishiwaki C., Kikuta T., Kumakura K., Nakamichi Y., and Nagamatsu S. Site of docking and fusion of insulin secretory granules in live MIN6 beta cells analyzed by TAT-conjugated anti-syntaxin 1 antibody and total internal reflection fluorescence microscopy. J. Biol. Chem. 279 (2004) 8403-8408
23. Frank P.G., Cheung M.W., Pavlides S., Llaverias G., Park D.S., and Lisanti M.P. Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H677-H686
24. Mulder H., Yang S., Winzell M.S., Holm C., and Ahren B. Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion. Diabetes 53 (2004) 122-128
25. Kanehara H., Suzuki J., Zenimaru Y., Takahashi S., Oida K., Shen W.J., Kraemer F.B., and Miyamori I. Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway. Diabetes Res. Clin. Pract. 65 (2004) 209-215
26. Fex M., Lucas S., Winzell M.S., Ahren B., Holm C., and Mulder H. {Beta}-cell lipases and insulin secretion. Diabetes 55 Suppl. 2 (2006) S24-S31