메뉴 건너뛰기




Volumn 25, Issue 5, 2003, Pages 552-557

An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography

Author keywords

2 ,2 difluorodeoxyuridine; Gemcitabine; HPLC; Ion pair; Plasma

Indexed keywords

FLOXURIDINE; GEMCITABINE; LY 198791; LY 264368;

EID: 0141923077     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200310000-00003     Document Type: Article
Times cited : (28)

References (12)
  • 1
    • 0032813135 scopus 로고    scopus 로고
    • Gemcitabine: A pharmacologic and clinical overview
    • Barton-Burke M. Gemcitabine: A pharmacologic and clinical overview. Cancer Nurs. 1999;22:176-183.
    • (1999) Cancer Nurs , vol.22 , pp. 176-183
    • Barton-Burke, M.1
  • 2
    • 0028105119 scopus 로고
    • Schedule dependence of sensitivity to 2′,2′ -difluorodeoxycytidine(gemeitabine) in relation to accumulation and retention of its triphosphate in solid tumor-cell lines and solid tumors
    • Vanhaperen VWTR, Veerman G, Boven E, et al. Schedule dependence of sensitivity to 2′,2′-difluorodeoxycytidine(gemeitabine) in relation to accumulation and retention of its triphosphate in solid tumor-cell lines and solid tumors. Biochem Pharmacol. 1994;48: 1327-1339.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1327-1339
    • Vanhaperen, V.W.T.R.1    Veerman, G.2    Boven, E.3
  • 3
    • 0025978216 scopus 로고
    • A phase-I clinical, plasma, and cellular pharmacology study of gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA, et al. A phase-I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol. 1991;9:491-498.
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 4
    • 0026550270 scopus 로고
    • Gemcitabine in leukemia-A phase-I clinical, plasma, and cellular pharmacology study
    • Grunewald R, Kantarjian H, Du M, et al. Gemcitabine in leukemia-A phase-I clinical, plasma, and cellular pharmacology study. J Clin Oncol. 1992;10:406-413.
    • (1992) J Clin Oncol , vol.10 , pp. 406-413
    • Grunewald, R.1    Kantarjian, H.2    Du, M.3
  • 5
    • 0029666336 scopus 로고    scopus 로고
    • Antitumor activity of prolonged as compared with bolus administration of 2′,2′-difluorodeoxycytidine in vivo against murine colon tumors
    • Veerman G, vanHaperen VWTR, Vermorken JB, et al. Antitumor activity of prolonged as compared with bolus administration of 2′,2′ -difluorodeoxycytidine in vivo against murine colon tumors. Cancer Chemoth Pharmacol. 1996;38:335-342.
    • (1996) Cancer Chemoth Pharmacol , vol.38 , pp. 335-342
    • Veerman, G.1    VanHaperen, V.W.T.R.2    Vermorken, J.B.3
  • 6
    • 0027495526 scopus 로고
    • Determination of the antimetabolite gemcitabine (2′,2′ -difluoro-2′-deoxycytine) and of 2′2′-difluoro-2′ -deoxyuridine by F-19 nuclear-magnetic-resonance spectroscopy
    • Edzes HT, Peters GJ, Noordhuis P, et al. Determination of the antimetabolite gemcitabine (2′,2′-difluoro-2′-deoxycytine) and of 2′2′-difluoro-2′-deoxyuridine by F-19 nuclear-magnetic-resonance spectroscopy. Anal Biochem. 1993;214:25-30.
    • (1993) Anal Biochem , vol.214 , pp. 25-30
    • Edzes, H.T.1    Peters, G.J.2    Noordhuis, P.3
  • 7
    • 0034905403 scopus 로고    scopus 로고
    • Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model
    • Guo PG, Ma JG, Li SL, et al. Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. Cancer Chemother Pharmacol. 2001; 48:169-176.
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 169-176
    • Guo, P.G.1    Ma, J.G.2    Li, S.L.3
  • 8
    • 18344416952 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and leukemia group B 9565
    • Venook AP, Egorin MJ, Rosner GL, et al. Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and leukemia group B 9565. J Clin Oncol. 2000; 18:2780-2787.
    • (2000) J Clin Oncol , vol.18 , pp. 2780-2787
    • Venook, A.P.1    Egorin, M.J.2    Rosner, G.L.3
  • 9
    • 0032983664 scopus 로고    scopus 로고
    • Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer
    • Kroep JR, Giaccone G, Voorn DA, et al. Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer. J Clin Oncol. 1999;17: 2190-2197.
    • (1999) J Clin Oncol , vol.17 , pp. 2190-2197
    • Kroep, J.R.1    Giaccone, G.2    Voorn, D.A.3
  • 10
    • 0028962811 scopus 로고
    • Validated assay for the determination of gemcitabine in human plasma and urine using high-performance chromatography with ultraviolet detection
    • Freeman KB, Anliker S, Hamilton M, et al. Validated assay for the determination of gemcitabine in human plasma and urine using high-performance chromatography with ultraviolet detection. J Chromatogr B. 1995;665:171-181.
    • (1995) J Chromatogr B , vol.665 , pp. 171-181
    • Freeman, K.B.1    Anliker, S.2    Hamilton, M.3
  • 11
    • 84988175795 scopus 로고
    • Analytical methods validation-bioavailability, bioequivalence, and pharmacokinetic studies
    • Shah VP, Midha KK, Dighe S, et al. Analytical methods validation-bioavailability, bioequivalence, and pharmacokinetic studies. J Pharml Sci. 1992;81(3):309-312.
    • (1992) J Pharml Sci , vol.81 , Issue.3 , pp. 309-312
    • Shah, V.P.1    Midha, K.K.2    Dighe, S.3
  • 12
    • 0033812959 scopus 로고    scopus 로고
    • The degradation of the antitumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products
    • Jansen PJ, Akers MJ, Amos RM, et al. The degradation of the antitumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products. J Pharml Sci. 2000;89:885-891.
    • (2000) J Pharml Sci , vol.89 , pp. 885-891
    • Jansen, P.J.1    Akers, M.J.2    Amos, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.