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Volumn 19, Issue 2, 2007, Pages 212-221

Clinical phase I and pharmacology study of gemcitabine (2′, 2′-difluorodeoxycytidine) administered in a two-weekly schedule

Author keywords

Difluorodeoxycytidine; Gemcitabine; Gemcitabine pharmacokinetics; Solid tumors

Indexed keywords

DIFLUORODEOXYURIDINE; FLOXURIDINE; GEMCITABINE; UNCLASSIFIED DRUG;

EID: 34247892237     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2007.19.2.212     Document Type: Article
Times cited : (34)

References (48)
  • 1
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of a (2′,2′-difluoro-2′-deoxycytidine)
    • Hertel LW, Boder GB, Kroin JS, et al. Evaluation of the antitumor activity of a (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50: 4417-4422..
    • (1990) Cancer Res , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 2
    • 0029802507 scopus 로고    scopus 로고
    • Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models
    • Merriman RL, Hertel LW, Schultz RM, et al. Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models. Invest New Drugs 1996; 14: 243-247.
    • (1996) Invest New Drugs , vol.14 , pp. 243-247
    • Merriman, R.L.1    Hertel, L.W.2    Schultz, R.M.3
  • 3
    • 0025977171 scopus 로고
    • Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (Gemcitabine) against head and neck cancer
    • Braakhuis BJ, van Dongen GAMS, Vermorken JB, Snow GB. Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (Gemcitabine) against head and neck cancer. Cancer Res. 1991; 51: 211-214.
    • (1991) Cancer Res , vol.51 , pp. 211-214
    • Braakhuis, B.J.1    van Dongen, G.A.M.S.2    Vermorken, J.B.3    Snow, G.B.4
  • 4
    • 0027263596 scopus 로고
    • The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer
    • Boven E, Schipper H, Erkelens CAM, Hatty SA, Pinedo HM. The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer. Br J Cancer 1993; 68: 52-56.
    • (1993) Br J Cancer , vol.68 , pp. 52-56
    • Boven, E.1    Schipper, H.2    Erkelens, C.A.M.3    Hatty, S.A.4    Pinedo, H.M.5
  • 6
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
    • Heinemann V, Hertel LW, Grindey GB, Plunkett W. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res 1988; 48: 4024-4031.
    • (1988) Cancer Res , vol.48 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 7
    • 0036462584 scopus 로고    scopus 로고
    • Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
    • Bergman AM, Pinedo HM, Peters GJ. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Updat 2002; 5: 19-33.
    • (2002) Drug Resist Updat , vol.5 , pp. 19-33
    • Bergman, A.M.1    Pinedo, H.M.2    Peters, G.J.3
  • 8
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998; 58: 4349-4357.
    • (1998) Cancer Res , vol.58 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3
  • 9
    • 0033520708 scopus 로고    scopus 로고
    • Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters
    • Mackey JR, Yao SY, Smith KM, et al. Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 1999; 91: 1876-1881.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1876-1881
    • Mackey, J.R.1    Yao, S.Y.2    Smith, K.M.3
  • 10
    • 0033981386 scopus 로고    scopus 로고
    • Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines
    • Van Moorsel CJ, Bergman AM, Veerman G, et al. Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines. Biochim Biophys Acta 2000; 1474: 5-12.
    • (2000) Biochim Biophys Acta , vol.1474 , pp. 5-12
    • Van Moorsel, C.J.1    Bergman, A.M.2    Veerman, G.3
  • 11
    • 0032898341 scopus 로고    scopus 로고
    • Decreased resistance to gemcitabine (2′,2′-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: Role of altered activity and substrate specificity of deoxycytidine kinase
    • Bergman AM, Pinedo HM, Jongsma AP, et al. Decreased resistance to gemcitabine (2′,2′-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase. Biochem Pharmacol 1999; 57: 397-406.
    • (1999) Biochem Pharmacol , vol.57 , pp. 397-406
    • Bergman, A.M.1    Pinedo, H.M.2    Jongsma, A.P.3
  • 12
    • 0028105119 scopus 로고
    • Schedule dependence of sensitivity to 2′,2′- difluorodeocytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours
    • Ruiz van Haperen VWT, Veerman G, Boven E, Noordhuis P, Vermorken JB, Peters GJ. Schedule dependence of sensitivity to 2′,2′- difluorodeocytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours. Biochem Pharmacol 1994; 48: 1327-1339.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1327-1339
    • Ruiz van Haperen, V.W.T.1    Veerman, G.2    Boven, E.3    Noordhuis, P.4    Vermorken, J.B.5    Peters, G.J.6
  • 13
    • 0028240063 scopus 로고
    • Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach DS, Hahn TM, Chang E, Hertel LW, Lawrence TS. Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 1994; 54: 3218-3223.
    • (1994) Cancer Res , vol.54 , pp. 3218-3223
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3    Hertel, L.W.4    Lawrence, T.S.5
  • 16
    • 0025978216 scopus 로고
    • A Phase I clinical, plasma, and cellular pharmacology study of Gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA, et al. A Phase I clinical, plasma, and cellular pharmacology study of Gemcitabine. J Clin Oncol 1991; 9: 491-498.
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 17
    • 0031114142 scopus 로고    scopus 로고
    • Preclinical, pharmacologic, and phase I studies of gemcitabine
    • Storniolo AM, Allerheiligen SR, Pearce HL. Preclinical, pharmacologic, and phase I studies of gemcitabine. Semin Oncol 1997; 24 (2 Suppl 7): 2-7.
    • (1997) Semin Oncol , vol.24 , Issue.2 SUPPL. 7 , pp. 2-7
    • Storniolo, A.M.1    Allerheiligen, S.R.2    Pearce, H.L.3
  • 18
    • 0026101039 scopus 로고
    • Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during a Phase I trial of gemcitabine
    • Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W. Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during a Phase I trial of gemcitabine. Cancer Chemother Pharmacol 1991; 27: 258-262.
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 258-262
    • Grunewald, R.1    Abbruzzese, J.L.2    Tarassoff, P.3    Plunkett, W.4
  • 20
    • 0030813204 scopus 로고    scopus 로고
    • Phase I study of gemcitabine using a once every 2 weeks schedule
    • Vermorken JB, Guastalla JP, Hatty SR, et al. Phase I study of gemcitabine using a once every 2 weeks schedule. Br J Cancer 1997; 76: 1489-1493.
    • (1997) Br J Cancer , vol.76 , pp. 1489-1493
    • Vermorken, J.B.1    Guastalla, J.P.2    Hatty, S.R.3
  • 21
    • 7344264012 scopus 로고    scopus 로고
    • Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors
    • Rothenberg ML, Sharma A, Weiss GR, et al. Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors. Ann Oncol 1998; 9: 733-738.
    • (1998) Ann Oncol , vol.9 , pp. 733-738
    • Rothenberg, M.L.1    Sharma, A.2    Weiss, G.R.3
  • 22
    • 0028962811 scopus 로고
    • Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid chromatography with ultraviolet detection
    • Freeman KB, Anliker S, Hamilton M, et al. Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed 1995; 665: 171-181.
    • (1995) J Chromatogr B Biomed , vol.665 , pp. 171-181
    • Freeman, K.B.1    Anliker, S.2    Hamilton, M.3
  • 24
    • 0027495526 scopus 로고
    • Determination of the antimetabolite Gemcitabine (2′,2′-difluoro-2′-deoxycytidine) and of 2′,2′-difluoro-2′- deoxyuridine by 19F nuclear magnetic resonance spectroscopy
    • Edzes HT, Peters GJ, Noordhuis P, Vermorken JB. Determination of the antimetabolite Gemcitabine (2′,2′-difluoro-2′-deoxycytidine) and of 2′,2′-difluoro-2′- deoxyuridine by 19F nuclear magnetic resonance spectroscopy. Anal Biochem 1993; 214: 25-30.
    • (1993) Anal Biochem , vol.214 , pp. 25-30
    • Edzes, H.T.1    Peters, G.J.2    Noordhuis, P.3    Vermorken, J.B.4
  • 25
    • 0025331551 scopus 로고
    • In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients
    • Peters GJ, Schwartsmann G, Nadal JC, Laurensse EJ, Van Groeningen CJ, Van der Vijgh WJ, Pinedo HM. In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients. Cancer Res 1990; 50: 4644-4649.
    • (1990) Cancer Res , vol.50 , pp. 4644-4649
    • Peters, G.J.1    Schwartsmann, G.2    Nadal, J.C.3    Laurensse, E.J.4    Van Groeningen, C.J.5    Van der Vijgh, W.J.6    Pinedo, H.M.7
  • 26
    • 0028067217 scopus 로고
    • Development and molecular characterization of a 2′,2′-difluorodeoxycytidine- resistant variant of the human overian carcinoma cell line A2780
    • Ruiz van Haperen VWT, Veerman G, Eriksson S, et al. Development and molecular characterization of a 2′,2′-difluorodeoxycytidine- resistant variant of the human overian carcinoma cell line A2780. Cancer Res 1994; 54: 4138-4143.
    • (1994) Cancer Res , vol.54 , pp. 4138-4143
    • Ruiz van Haperen, V.W.T.1    Veerman, G.2    Eriksson, S.3
  • 27
    • 0024792447 scopus 로고
    • Pharmacokinetics of Brequinar sodium (NSC 368390) in patients with solid tumors during a phase I study
    • Schwartsmann G, Van der Vijgh WJ, Van Hennik MB, et al. Pharmacokinetics of Brequinar sodium (NSC 368390) in patients with solid tumors during a phase I study. Eur J Cancer Clin Oncol 1989; 25 : 1675-1681.
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 1675-1681
    • Schwartsmann, G.1    Van der Vijgh, W.J.2    Van Hennik, M.B.3
  • 30
    • 23044435447 scopus 로고    scopus 로고
    • Prolonged fixed doxe rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma
    • Bengala C, Guarneri V, Giovannetti E, et al. Prolonged fixed doxe rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma. Br J Cancer 2005; 93:35-40.
    • (2005) Br J Cancer , vol.93 , pp. 35-40
    • Bengala, C.1    Guarneri, V.2    Giovannetti, E.3
  • 31
    • 28344451022 scopus 로고    scopus 로고
    • No evidence of gemcitabine accumulation during weekly administration
    • De Lange SM, Van der Born K, Kroep JR, et al. No evidence of gemcitabine accumulation during weekly administration. Eur J Clin Pharmacol 2005; 61: 843-849.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 843-849
    • De Lange, S.M.1    Van der Born, K.2    Kroep, J.R.3
  • 32
    • 0029797913 scopus 로고    scopus 로고
    • NONMEM population pharmacokinetic studies of cytosine arabinoside after high-dose and after loading bolus followed by continuous infusion of the drug in pediatric patients with leukemias
    • Periclou AP, Avramis VI. NONMEM population pharmacokinetic studies of cytosine arabinoside after high-dose and after loading bolus followed by continuous infusion of the drug in pediatric patients with leukemias. Cancer Chemother Pharmacol 1996; 39: 42-50.
    • (1996) Cancer Chemother Pharmacol , vol.39 , pp. 42-50
    • Periclou, A.P.1    Avramis, V.I.2
  • 34
    • 33645692656 scopus 로고    scopus 로고
    • Gemcitabine pharmacogenomics: Cytidine deaminase and deoxycytidylate deaminase gene resequencing and funtional genomics
    • Gilbert JA, Salavaggione OE, Ji Y, et al. Gemcitabine pharmacogenomics: Cytidine deaminase and deoxycytidylate deaminase gene resequencing and funtional genomics. Clin Cancer Res. 2006; 12: 1794-1803.
    • (2006) Clin Cancer Res , vol.12 , pp. 1794-1803
    • Gilbert, J.A.1    Salavaggione, O.E.2    Ji, Y.3
  • 35
    • 0022501789 scopus 로고
    • Phase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patients
    • Van Groeningen CJ, Leyva A, O'Brien AM, Gall HE, Pinedo HM. Phase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patients. Cancer Res 1986; 46: 4831-4836.
    • (1986) Cancer Res , vol.46 , pp. 4831-4836
    • Van Groeningen, C.J.1    Leyva, A.2    O'Brien, A.M.3    Gall, H.E.4    Pinedo, H.M.5
  • 36
    • 0025935563 scopus 로고
    • On the pharmacokinetics of 2-chloro-2′- deoxyadenosine in humans
    • Liliemark J, Juliusson G. On the pharmacokinetics of 2-chloro-2′- deoxyadenosine in humans. Cancer Res 1991; 51: 5570-5572.
    • (1991) Cancer Res , vol.51 , pp. 5570-5572
    • Liliemark, J.1    Juliusson, G.2
  • 37
    • 0033800910 scopus 로고    scopus 로고
    • Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs
    • Bergman AM, Giaccone G, Van Moorsel CJ, Mauritz R, Noordhuis P, Pinedo HM, Peters GJ. Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs. Eur J Cancer 2001; 36: 1974-1983.
    • (2001) Eur J Cancer , vol.36 , pp. 1974-1983
    • Bergman, A.M.1    Giaccone, G.2    Van Moorsel, C.J.3    Mauritz, R.4    Noordhuis, P.5    Pinedo, H.M.6    Peters, G.J.7
  • 38
    • 0032994472 scopus 로고    scopus 로고
    • Human thymidine kinase 2: Molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
    • Wang L, Munch-Petersen B, Herrstrom Sjoberg A, Hellman U, Bergman T, Jornvall H, Eriksson S. Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates. FEBS Lett 1999; 443: 170-174.
    • (1999) FEBS Lett , vol.443 , pp. 170-174
    • Wang, L.1    Munch-Petersen, B.2    Herrstrom Sjoberg, A.3    Hellman, U.4    Bergman, T.5    Jornvall, H.6    Eriksson, S.7
  • 39
    • 0029162556 scopus 로고
    • Mammalian deoxyribonucleoside kinases
    • Arner ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 1995; 67: 155-186.
    • (1995) Pharmacol Ther , vol.67 , pp. 155-186
    • Arner, E.S.1    Eriksson, S.2
  • 40
    • 0029990087 scopus 로고    scopus 로고
    • Regulation of phosphorylation of deoxycytidine and 2′,2′- difluorodeoxycytidine (Gemcitabine); effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine
    • Ruiz van Haperen VWT, Veerman G, Vermorken JB, Pinedo HM, Peters GJ. Regulation of phosphorylation of deoxycytidine and 2′,2′- difluorodeoxycytidine (Gemcitabine); effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine. Biochem Pharmacol 1996; 51: 911-918.
    • (1996) Biochem Pharmacol , vol.51 , pp. 911-918
    • Ruiz van Haperen, V.W.T.1    Veerman, G.2    Vermorken, J.B.3    Pinedo, H.M.4    Peters, G.J.5
  • 41
    • 0027085703 scopus 로고
    • Nucleotide specificity of human deoxycytidine kiinase
    • Shewach DS, Reynolds KK, Hertel L. Nucleotide specificity of human deoxycytidine kiinase. Mol Pharmacol 1992; 42: 518-524.
    • (1992) Mol Pharmacol , vol.42 , pp. 518-524
    • Shewach, D.S.1    Reynolds, K.K.2    Hertel, L.3
  • 42
    • 0032983664 scopus 로고    scopus 로고
    • Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer
    • Kroep JR, Giaccone G, Voorn DA, et al. Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer. J Clin Oncol 1999; 17: 2190-2197.
    • (1999) J Clin Oncol , vol.17 , pp. 2190-2197
    • Kroep, J.R.1    Giaccone, G.2    Voorn, D.A.3
  • 43
    • 0032939255 scopus 로고    scopus 로고
    • Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors
    • Van Moorsel CJ, Kroep JR, Pinedo HM, et al. Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors. Ann Oncol 1999; 10: 441-448.
    • (1999) Ann Oncol , vol.10 , pp. 441-448
    • Van Moorsel, C.J.1    Kroep, J.R.2    Pinedo, H.M.3
  • 44
    • 0020604076 scopus 로고
    • Purine and pyrimidine metabolism in peripheral blood lymphocytes (Review)
    • Peters GJ, Veerkamp JH. Purine and pyrimidine metabolism in peripheral blood lymphocytes (Review). Int J Biochem 1983; 15: 115-123.
    • (1983) Int J Biochem , vol.15 , pp. 115-123
    • Peters, G.J.1    Veerkamp, J.H.2
  • 45
    • 0344443811 scopus 로고    scopus 로고
    • Mammalian 5′-nucleotidases
    • Bianchi V, Spychala J. Mammalian 5′-nucleotidases. J Biol Chem 2003; 278: 46195-46198.
    • (2003) J Biol Chem , vol.278 , pp. 46195-46198
    • Bianchi, V.1    Spychala, J.2
  • 46
    • 0036467995 scopus 로고    scopus 로고
    • Prolonged infusion of gemcitabine: Clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia
    • Gandhi V, Plunkett W, Du M, Ayres M, Estey EH. Prolonged infusion of gemcitabine: clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia. J Clin Oncol 2002; 20: 665-673.
    • (2002) J Clin Oncol , vol.20 , pp. 665-673
    • Gandhi, V.1    Plunkett, W.2    Du, M.3    Ayres, M.4    Estey, E.H.5
  • 47
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz van Haperen V, Hainsworth J, Hochster H, Lenzi R, Abbruzzese J. Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003; 21: 3402-3408.
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz van Haperen, V.3    Hainsworth, J.4    Hochster, H.5    Lenzi, R.6    Abbruzzese, J.7


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