Transcriptional regulation by ergosterol in the yeast Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5427-5432

  Smith, Steven J ^a,b   Crowley, James H ^a   Parks, Leo W ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BETA GALACTOSIDASE; ERGOSTEROL; HEME; OXYGEN;

AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGUS GROWTH; GENE EXPRESSION REGULATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEROL SYNTHESIS; TRANSCRIPTION REGULATION; YEAST;

BACTERIA (MICROORGANISMS); FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0029833459     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5427     Document Type: Article

References (43)

1. Alberts, A. W., J. Chen, G. Kuron, V. Hunt, C. Huff, C. Hoffman, J. Rothrock, M. Lopez, H. Joshua, A. Patchett, R. Monaghan, S. Currie, E. Stapley, G. Albers-Schonberg, J. Hirchfield, K. Hoogsteen, J. Liesch, and J. Springer. 1980. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl CoA reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77:3957-3961.
2. Andreasen, A. A., and T. J. B. Stier. 1953. Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium. J. Cell. Comp. Physiol. 41:23-36.
3. Arthington, B. A., L. G. Bennett, P. L. Skatrud, C. J. Guynn, T. J. Barbuch, C. E. Ubright, and M. Bard. 1991. Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102:39-44.
4. Baloch, R. I., and E. I. Mercer. 1987. Inhibition of sterol 8-7 isomerase and 14 reductase by fenpropimorph, tridemorph, and fenpropidin in cell-free enzyme systems from Saccharomyces cerevisiae. Phytochemistry 26:663-668.
5. Baloch, R. I., E. I. Mercer, T. E. Wiggins, and B. C. Baldwin. 1984. Inhibition of ergosterol biosynthesis in Saccharomyces cerevisiae and Ustilago maydis by tridemorph, fenpropimorph, and fenpropidin. Phytochemistry 23:2219-2226.
6. Becker, D. M., and L. Guarente. 1991. High-efficiency transformation of yeast by electroporation. Methods Enzymol. 194:182-186.
7. Brown, M. S., and J. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47.
8. Brown, T. 1993. Analysis of RNA by Northern and slot Wot hybridization. Curr. Protoc. Mol. Biol. 1:4.9.1-4.9.14.
9. Brown, T. A., and B. L. Trumpower. 1995. Strain-dependent variation in carbon source regulation of nucleus-encoded mitochondrial proteins of Saccharomyces cerevisiae. J. Bacteriol. 117:1380-1382.
10. Burden, R. S., D. T. Cooke, and G. A. Carter. 1989. Inhibitors of sterol biosynthesis and growth in plants and fungi. Phytochemistry 28:1791-1804.
11. Casey, W. M., J. P. Burgess, and L. W. Parks. 1991. Effect of sterol side-chain structure on the feed-back control of sterol biosynthesis in yeast. Biochim. Biophys. Acta 1081:279-284.
12. Casey, W. M., G. A. Keesler, and L. W. Parks. 1992. Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae. J. Bacteriol. 174:7283-7288.
13. Collart, M. A. and S. Oliviero. 1993. Preparation of yeast RNA. Curr. Protoc. Mol. Biol. 2:13.12.1-13.12.5.
14. Dimster-Denk, D., M. K. Thorsness, and J. Rine. 1994. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae. Mol. Biol. Cell 580:655-665.
15. Gaber, R. F., D. M. Copple, B. K. Kennedy, M. Vidal, and M. Bard. 1989. The yeast gene ERG6 is required for normal membrane function by is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 9:3447-3456.
16. Gietz, D., A. St. Jean, R. A. Woods, and R. H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20:1425.
17. Goldstein, J., and M. S. Brown. 1990. Regulation of the mevalonate pathway. Nature (London) 343:425-430.
18. Hanahan, D. 1983. Studies an transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
19. Hill, J. E., A. M. Myers, T. J. Koerner, and A. Tzagoloff. 1986. Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast 2:163-167.
20. Köhrer, K., and H. Domdey. 1991. Preparation of high molecular weight RNA. Methods Enzymol. 194:398-405.
21. Lewis, T. A., G. A. Keesler, G. P. Fenner, and L. W. Parks. 1988. Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism. Yeast 4:93-106.
22. Lorenz, R. T., W. M. Casey, and L. W. Parks. 1989. Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae. J. Bacteriol. 171:6169-6173.
23. Lorenz, R. T., and L. W. Parks. 1990. Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 34:1660-1665.
24. Lorenz, R. T., and L. W. Parks. 1991. Involvement of heme components in sterol metabolism of Saccharomyces cerevisiae. Lipids 26:598-603.
25. Manivasakam, P., S. C. Weber, J. McElver, and R. H. Schiestl. Microhomology mediated PCR targeting in Saccharomyces cerevisiae. Nucleic Acids Res. 23:2799-2800.
26. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y.
27. Myers, A, M., A. Tzagoloff, D. M. Kinney, and C. J. Lusty. 1986. Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45:299-310.
28. Parks, L. W., C. D. K. Bottema, R. J. Rodriguez, and T. A. Lewis. 1985. Yeast sterols: yeast mutants as tools for the study of sterol metabolism. Methods Enzymol. 111:333-346.
29. Parks, L. W., and W. M. Casey. 1995. Physiological implications of sterol biosynthesis in yeast. Annu. Rev. Microbiol. 49:95-116.
30. Parks, L. W., C. McLean-Bowen, F. R. Taylor, and S. Hough. 1978. Sterols in yeast subcellular fractions. Lipids 13:730-735.
31. Parks, L. W., S. J. Smith, and J. H. Crowley. 1995. Biochemical and physiological effects of sterol alterations in yeast - a review. Lipids 30:227-230.
32. Rodriguez, R. J., C. Low, C. D. K. Bottema, and L. W. Parks. 1985. Multiple functions for sterols in Saccharomyces cerevisiae. Biochim. Biophys. Acta 837:336-343.
33. Rose, M. D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N. Y.
34. Ruthstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
35. Sambrook, J., E. R. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
36. Sanchez, H. B., L. Yieh, and T. F. Osborne. 1995. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270:1161-1169.
37. Sheng, Z., H. Otani, M. S. Brown, and J. L. Goldstein. 1995. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 92:935-938.
38. Skaggs, B. A., J. F. Alexander, C. A. Pierson, K. S. Schweitzer, K. T. Chun, C. Koegel, R. Barbuch, and M, Bard. 1996. Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. Gene 169:105-109.
39. Skipski, B. P., A. F. Smolove, R. C. Sullivan, and M. Barclay. 1965. Separation of lipid classes by thin layer chromatography. Biochim. Biophys. Acta 106:386-396.
40. Smith, S. J., and L. W. Parks. 1993. The ERG3 gene in Saccharomyces cerevisiae is required for the utilization of respiratory substrates and in heme-deficient cells. Yeast 9:1177-1187.
41. Thorsness, M., W. Schafer, L. D'ari, and J. Rine. 1989. Positive and negative transcriptional control by heme of genes encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:5702-5712.
42. Ushinsky, S. C., and T. Keng. 1994. A novel allele of HAPI causes uninducible expression of HEM13 in Saccharomyces cerevisiae. Genetics 136:819-831.
43. Vanden Bossohe, H. W. Lauwers, G. Willemsens, P. Marichal, F. Cornelissen, and W. Cools. 1984. Molecular basis for the antimycotic and antibacterial activity of N-substituted imidazoles and triazoles: the inhibition of isoprenoid biosynthesis. Pestic. Sci. 15:188-198.