Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: Implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis

Journal of the Neurological Sciences

Volumn 189, Issue 1-2, 2001, Pages 65-69

  Tomiyama, Masahiko ^a   Kimura, Tamaki ^a   Maeda, Tetsuya ^a   Tanaka, Hiroyasu ^a   Furusawa, Kenichi ^a   Kurahashi, Kozo ^b   Matsunaga, Muneo ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b AOMORI PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

ALS; Excitotoxicity; In situ hybridization; mGluR; Motor neuron death; Motor neuron disease

Indexed keywords

EXCITOTOXIN; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NEUROPROTECTION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD DORSAL HORN; SPINAL CORD MOTONEURON;

AGED; CELL SIZE; DISEASE SUSCEPTIBILITY; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; MOTOR NEURON DISEASE; MOTOR NEURONS; NERVE TISSUE PROTEINS; PROTEIN ISOFORMS; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER; SPINAL CORD;

EID: 0035881425     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(01)00561-5     Document Type: Article

References (16)

1. Excitotoxicity and motor neuron disease: a review of the evidence
2. Excitotoxicity hypothesis
3. The role of excitotoxicity in ALS-what is the evidence?
4. Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis
5. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
6. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
7. Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons
8. Activation of metabotropic glutamate receptors delays apoptosis of chick embryonic motor neurons in vitro
9. Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat
10. Pharmacology and function of metabotropic glutamate receptors
11. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study
12. Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation-induced peripheral inflammation
13. Distribution and developmental changes in metabotropic glutamate receptors messenger RNA expression in the rat lumbar spinal cord
14. Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization
15. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
16. Differential expression of group I metabotropic glutamate receptors in rat spinal cord somatic and autonomic motoneurons: possible implications for the pathogenesis of amyotrophic lateral sclerosis