Drosophila mars is required for organizing kinetochore microtubules during mitosis

Experimental Cell Research

Volumn 314, Issue 17, 2008, Pages 3209-3220

  Yang, Ching Po ^a   Fan, Seng Sheen ^a  

^a TUNGHAI UNIVERSITY   (Taiwan)

Author keywords

Drosophila; Kinetochore; Mars; Mitosis; Mitotic spindle

Indexed keywords

DROSOPHILA PROTEIN; MARS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CELLULAR DISTRIBUTION; CENTROMERE; CHROMOSOME; CONTROLLED STUDY; DROSOPHILA; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE;

EID: 53049088142     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.08.004     Document Type: Article

References (39)

1. Cleveland D.W., Mao Y., and Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112 (2003) 407-421
2. Mitchison T., and Kirschner M. Dynamic instability of microtubule growth. Nature 312 (1984) 237-242
3. Hayden J.H., Bowser S.S., and Rieder C.L. Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells. J. Cell Biol. 111 (1990) 1039-1045
4. Rieder C.L., and Alexander S.P. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 110 (1990) 81-95
5. Lüders J., and Stearns T. Microtubule-organizing centres: a re-evaluation. Nat. Rev. Mol. Cell Biol. 8 (2007) 161-167
6. O'Connell C.B., and Khodjakov A.L. Cooperative mechanisms of mitotic spindle formation. J. Cell Sci. 120 (2007) 1717-1722
7. Karsenti E., Newport J., and Kirschner M. Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase. J. Cell Biol. 99 (1984) 47s-54s
8. Maiato H., Rieder C.L., and Khodjakov A. Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J. Cell Biol. 167 (2004) 831-840
9. Heald R., Tournebize R., Blank T., Sandaltzopoulos R., Becker P., Hyman A., and Karsenti E. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382 (1996) 420-425
10. Matthies H.J., McDonald H.B., Goldstein L.S., and Theurkauf W.E. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J. Cell Biol. 134 (1996) 455-464
11. Khodjakov A., Cole R.W., Oakley B.R., and Rieder C.L. Centrosome-independent mitotic spindle formation in vertebrates. Curr. Biol. 10 (2000) 59-67
12. Carazo-Salas R.E., Guarguaglini G., Gruss O.J., Segref A., Karsenti E., and Mattaj I.W. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400 (1999) 178-181
13. Ohba T., Nakamura M., Nishitani H., and Nishimoto T. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science 284 (1999) 1356-1358
14. Wilde A., and Zheng Y. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science 284 (1999) 1359-1362
15. Hetzer M., Gruss O.J., and Mattaj I.W. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat. Cell Biol. 4 (2002) 177-184
16. Tsou A.P., Yang C.W., Huang C.Y., Yu R.C., Lee Y.C., Chang C.W., Chen B.R., Chung Y.F., Fann M.J., Chi C.W., Chiu J.H., and Chou C.K. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22 (2003) 298-307
17. Kim E., Naisbitt S., Hsueh Y.P., Rao A., Rothschild A., Craig A.M., and Sheng M. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J. Cell Biol. 136 (1997) 669-678
18. Crane R., Gadea B., Littlepage L., Wu H., and Ruderman J.V. Aurora A, meiosis and mitosis. Biol. Cell 96 (2004) 215-229
19. Ducat D., and Zheng Y. Aurora kinases in spindle assembly and chromosome segregation. Exp. Cell Res. 301 (2004) 60-67
20. Yu C.T., Hsu J.M., Lee Y.C., Tsou A.P., Chou C.K., and Huang C.Y. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell Biol. 25 (2005) 5789-5800
21. Koffa M.D., Casanova C.M., Santarella R., Köcher T., Wilm M., and Mattaj I.W. HURP is part of a Ran-dependent complex involved in spindle formation. Curr. Biol. 16 (2006) 743-754
22. Silljé H.H., Nagel S., Körner R., and Nigg E.A. HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr. Biol. 16 (2006) 731-742
23. Wong J., and Fang G. HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J. Cell Biol. 173 (2006) 879-891
24. Wong J., Lerrigo R., Jang C.Y., and Fang G. Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol. Biol Cell. 19 (2008) 2083-2091
25. Bennett D., and Alphey L. Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila. Gene Expr. Patterns 4 (2004) 529-535
26. Yang C.P., Chen M.S., Liaw G.J., Chen S.F., Chou G., and Fan S.S. Using Drosophila eye as a model system to characterize the function of mars gene in cell-cycle regulation. Exp. Cell Res. 307 (2005) 183-193
27. Tan S., Lyulcheva E., Dean J., and Bennett D. Mars promotes dTACC dephosphorylation on mitotic spindle to ensure spindle stability. J. Cell Biol. 182 (2008) 27-33
28. Cullen C.F., Deák P., Glover D.M., and Ohkura H. Mini spindles: a gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila. J. Cell Biol. 146 (1999) 1005-1018
29. Rieder C.L. The structure of the cold-stable kinetochore fiber in metaphase PtK1 cells. Chromosoma 84 (1981) 145-158
30. Blower M.D., and Karpen G.H. The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat. Cell Biol. 3 (2001) 730-739
31. Przewloka M.R., Zhang W., Costa P., Archambault V., D'Avino P.P., Lilley K.S., Laue E.D., McAinsh A.D., and Glover D.M. Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster. PLoS ONE 2 (2007) e478
32. Lüders J., Patel U.K., and Stearns T. GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. Nat. Cell Biol. 8 (2006) 137-147
33. Buster D.W., Zhang D., and Sharp D.J. Poleward tubulin flux in spindles: regulation and function in mitotic cells. Mol. Cell Biol 18 (2007) 3094-3104
34. Vardy L., and Toda T. The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint. EMBO J. 19 (2000) 6098-6111
35. Kalab P., Pu R.T., and Dasso M. The ran GTPase regulates mitotic spindle assembly. Curr. Biol. 9 (1999) 481-484
36. Schiebel E. gamma-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Curr. Opin. Cell Biol. 12 (2000) 113-118
37. Zhou J., Yao J., and Joshi H.C. Attachment and tension in the spindle assembly checkpoint. J. Cell Sci. 115 (2002) 3547-3555
38. Liu S.T., Hittle J.C., Jablonski S.A., Campbell M.S., Yoda K., and Yen T.J. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat. Cell Biol. 5 (2003) 341-345
39. Xiao H., Verdier-Pinard P., Fernandez-Fuentes N., Burd B., Angeletti R., Fiser A., Horwitz S.B., and Orr G.A. Insights into the mechanism of microtubule stabilization by Taxol. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 10166-10173