Pyrazino[1,2-b]isoquinolines: Synthesis and study of their cytostatic and cytotoxic properties

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 9065-9078

  Ortín, Irene ^a   González, Juan Francisco ^a   Cuesta, Elena de la ^a   Manguan García, Cristina ^b   Perona, Rosario ^b,c   Avendaño, Carmen ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Antitumor agents; Apoptosis; Cell cycle transitions; DNA interaction; Tetrahydroisoquinolines

Indexed keywords

6 BENZYLOXYMETHYL 2 ISOPROPYLOXYCARBONYL 7,8,10 TRIMETHOXY 9 METHYL 1,2,3,6,11,11A HEXAHYDROPYRAZINO[1,2 B]ISOQUINOLIN 4 ONE; ISOQUINOLINE DERIVATIVE; PYRAZINO[1,2 B]ISOQUINOLINE DERIVATIVE; TRABECTEDIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CYTOSTASIS; DNA DAMAGE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LC 50; REACTION ANALYSIS;

ADENOCARCINOMA; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CYTOSTATIC AGENTS; DNA DAMAGE; G1 PHASE; G2 PHASE; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; S PHASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949137871     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.083     Document Type: Article

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