Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 9040-9049

  Braud, Emmanuelle ^a,b   Goddard, Mary Lorène ^a,b   Kolb, Stéphanie ^a,b   Brun, Marie Priscille ^a,b   Mondésert, Odile ^c   Quaranta, Muriel ^c   Gresh, Nohad ^a,b   Ducommun, Bernard ^c   Garbay, Christiane ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Cancer; Cell cycle regulation; Phosphatase CDC25; Quinone derivatives

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYCLIN DEPENDENT KINASE; MALONIC ACID DERIVATIVE; NSC 95397; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE REGULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CDC25 PHOSPHATASES; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MALONATES; MOLECULAR MIMICRY; NAPHTHOQUINONES; PHOSPHATES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949133383     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.009     Document Type: Article

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