Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 46877-46885

  Pu, Lixia ^a   Amoscato, Andrew A ^a   Bier, Mark E ^b   Lazo, John S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; CELLS; CHEMICAL ACTIVATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CELL CYCLE PROGRESSION;

ENZYME INHIBITION;

7 CHLORO 6 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; ANTIMITOTIC AGENT; CYCLIN A; CYCLIN DEPENDENT KINASE 2; ENZYME INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; CDK4 PROTEIN, HUMAN; CDK4 PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; NSC 663284; ONCOPROTEIN; PHOSPHATASE; QUINOLONE DERIVATIVE; QUINONE DERIVATIVE; RECOMBINANT PROTEIN; TRYPSIN;

ANIMAL CELL; ARTICLE; CAPILLARY CHROMATOGRAPHY; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL SYNCHRONIZATION; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ANIMAL; CELL CULTURE; CELL CYCLE; CELL DIVISION; CHEMICAL MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; TEMPERATURE; TIME; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CDC25 PHOSPHATASE; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; HUMANS; MICE; MODELS, CHEMICAL; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; QUINOLONES; QUINONES; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE; TIME FACTORS; TRYPSIN; TUMOR CELLS, CULTURED;

EID: 0037032557     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207902200     Document Type: Article

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