Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 16, 2005, Pages 4871-4879

  Brun, Marie Priscille ^a   Braud, Emmanuelle ^a   Angotti, Delphine ^a   Mondésert, Odile ^b   Quaranta, Muriel ^b   Montes, Matthieu ^a   Miteva, Maria ^a   Gresh, Nohad ^a   Ducommun, Bernard ^b   Garbay, Christiane ^a  

^a CNRS   (France)

^b Université de Toulouse Paul Sabatier   (France)

Author keywords

Cancer; CDC25 phosphatases; Naphthoquinones; Signal transduction

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; MENADIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TYROSINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NAPHTHOQUINONES; RECOMBINANT PROTEINS; VITAMIN K 3;

EUKARYOTA;

EID: 21744440254     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.005     Document Type: Article

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