-
1
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
Postic C., and Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 118 (2008) 829-838
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
2
-
-
17844401704
-
Anatomy and regulation of the central melanocortin system
-
Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8 (2005) 571-578
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 571-578
-
-
Cone, R.D.1
-
3
-
-
34250612718
-
The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics
-
Oswal A., and Yeo G.S.H. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obes. Rev. 8 (2007) 293-306
-
(2007)
Obes. Rev.
, vol.8
, pp. 293-306
-
-
Oswal, A.1
Yeo, G.S.H.2
-
4
-
-
0017115523
-
Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice
-
Yen T.T., Allan J.A., Yu P.L., Acton M.A., and Pearson D.V. Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice. Biochim. Biophys. Acta 441 (1976) 213-220
-
(1976)
Biochim. Biophys. Acta
, vol.441
, pp. 213-220
-
-
Yen, T.T.1
Allan, J.A.2
Yu, P.L.3
Acton, M.A.4
Pearson, D.V.5
-
5
-
-
1042275338
-
Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice
-
Albarado D.C., McClaine J., Stephens J.M., Mynatt R.L., Ye J., Bannon A.W., Richards W.G., and Butler A.A. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology 145 (2004) 243-252
-
(2004)
Endocrinology
, vol.145
, pp. 243-252
-
-
Albarado, D.C.1
McClaine, J.2
Stephens, J.M.3
Mynatt, R.L.4
Ye, J.5
Bannon, A.W.6
Richards, W.G.7
Butler, A.A.8
-
6
-
-
0030062529
-
Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity
-
Jones B.H., Kim J.H., Zemel M.B., Woychik R.P., Michaud E.J., Wilkison W.O., and Moustaid N. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am. J. Physiol. 270 (1996) E192-E196
-
(1996)
Am. J. Physiol.
, vol.270
-
-
Jones, B.H.1
Kim, J.H.2
Zemel, M.B.3
Woychik, R.P.4
Michaud, E.J.5
Wilkison, W.O.6
Moustaid, N.7
-
7
-
-
0242331290
-
CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression
-
Lin J., Choi Y.H., Hartzell D.L., Li C., Della-Fera M.A., and Baile C.A. CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Biochem. Biophys. Res. Commun. 311 (2003) 324-328
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.311
, pp. 324-328
-
-
Lin, J.1
Choi, Y.H.2
Hartzell, D.L.3
Li, C.4
Della-Fera, M.A.5
Baile, C.A.6
-
8
-
-
0242300570
-
Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
-
Mizuno T.M., Kelley K.A., Pasinetti G.M., Roberts J.L., and Mobbs C.V. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52 (2003) 2675-2683
-
(2003)
Diabetes
, vol.52
, pp. 2675-2683
-
-
Mizuno, T.M.1
Kelley, K.A.2
Pasinetti, G.M.3
Roberts, J.L.4
Mobbs, C.V.5
-
9
-
-
34547103515
-
Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss
-
Li G., Zhang Y., Rodrigues E., Zheng D., Matheny M., Cheng K.Y., and Scarpace P.J. Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss. Am. J. Physiol. Endocrinol. Metab. 293 (2007) E252-E258
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Li, G.1
Zhang, Y.2
Rodrigues, E.3
Zheng, D.4
Matheny, M.5
Cheng, K.Y.6
Scarpace, P.J.7
-
10
-
-
0035873079
-
Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats
-
Adage T., Scheurink A.J., de Boer S.F., de Vries K., Konsman J.P., Kuipers F., Adan R.A., Baskin D.G., Schwartz M.W., and van Dijk G. Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats. J. Neurosci. 21 (2001) 3639-3645
-
(2001)
J. Neurosci.
, vol.21
, pp. 3639-3645
-
-
Adage, T.1
Scheurink, A.J.2
de Boer, S.F.3
de Vries, K.4
Konsman, J.P.5
Kuipers, F.6
Adan, R.A.7
Baskin, D.G.8
Schwartz, M.W.9
van Dijk, G.10
-
11
-
-
36048955043
-
The central melanocortin system directly controls peripheral lipid metabolism
-
Nogueiras R., Wiedmer P., Perez-Tilve D., Veyrat-Durebex C., Keogh J.M., Sutton G.M., Pfluger P.T., Castaneda T.R., Neschen S., Hofmann S.M., Howles P.N., Morgan D.A., Benoit S.C., Szanto I., Schrott B., Schurmann A., Joost H.G., Hammond C., Hui D.Y., Woods S.C., Rahmouni K., Butler A.A., Farooqi I.S., O'Rahilly S., Rohner-Jeanrenaud F., and Tschop M.H. The central melanocortin system directly controls peripheral lipid metabolism. J. Clin. Invest. 117 (2007) 3475-3488
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3475-3488
-
-
Nogueiras, R.1
Wiedmer, P.2
Perez-Tilve, D.3
Veyrat-Durebex, C.4
Keogh, J.M.5
Sutton, G.M.6
Pfluger, P.T.7
Castaneda, T.R.8
Neschen, S.9
Hofmann, S.M.10
Howles, P.N.11
Morgan, D.A.12
Benoit, S.C.13
Szanto, I.14
Schrott, B.15
Schurmann, A.16
Joost, H.G.17
Hammond, C.18
Hui, D.Y.19
Woods, S.C.20
Rahmouni, K.21
Butler, A.A.22
Farooqi, I.S.23
O'Rahilly, S.24
Rohner-Jeanrenaud, F.25
Tschop, M.H.26
more..
-
12
-
-
50049131792
-
Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice
-
Kim E.R., Leckstrom A., and Mizuno T.M. Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice. Behav. Brain Res. 194 (2008) 66-71
-
(2008)
Behav. Brain Res.
, vol.194
, pp. 66-71
-
-
Kim, E.R.1
Leckstrom, A.2
Mizuno, T.M.3
-
13
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., and Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115 (2005) 1343-1351
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
14
-
-
14544289119
-
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver
-
Dentin R., Girard J., and Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 87 (2005) 81-86
-
(2005)
Biochimie
, vol.87
, pp. 81-86
-
-
Dentin, R.1
Girard, J.2
Postic, C.3
-
15
-
-
0033544940
-
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
-
Shimano H., Yahagi N., Amemiya-Kudo M., Hasty A.H., Osuga J., Tamura Y., Shionoiri F., Iizuka Y., Ohashi K., Harada K., Gotoda T., Ishibashi S., and Yamada N. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J. Biol. Chem. 274 (1999) 35832-35839
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35832-35839
-
-
Shimano, H.1
Yahagi, N.2
Amemiya-Kudo, M.3
Hasty, A.H.4
Osuga, J.5
Tamura, Y.6
Shionoiri, F.7
Iizuka, Y.8
Ohashi, K.9
Harada, K.10
Gotoda, T.11
Ishibashi, S.12
Yamada, N.13
-
16
-
-
0035979214
-
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
-
Yamashita H., Takenoshita M., Sakurai M., Bruick R.K., Henzel W.J., Shillinglaw W., Arnot D., and Uyeda K. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc. Natl. Acad. Sci. USA 98 (2001) 9116-9121
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9116-9121
-
-
Yamashita, H.1
Takenoshita, M.2
Sakurai, M.3
Bruick, R.K.4
Henzel, W.J.5
Shillinglaw, W.6
Arnot, D.7
Uyeda, K.8
-
17
-
-
8144229872
-
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
-
Ishii S., Iizuka K., Miller B.C., and Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc. Natl. Acad. Sci. USA 101 (2004) 15597-15602
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15597-15602
-
-
Ishii, S.1
Iizuka, K.2
Miller, B.C.3
Uyeda, K.4
-
18
-
-
0037373008
-
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
-
Matsusue K., Haluzik M., Lambert G., Yim S.H., Gavrilova O., Ward J.M., Brewer Jr. B., Reitman M.L., and Gonzalez F.J. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J. Clin. Invest. 111 (2003) 737-747
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 737-747
-
-
Matsusue, K.1
Haluzik, M.2
Lambert, G.3
Yim, S.H.4
Gavrilova, O.5
Ward, J.M.6
Brewer Jr., B.7
Reitman, M.L.8
Gonzalez, F.J.9
-
19
-
-
0141446024
-
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
-
Gavrilova O., Haluzik M., Matsusue K., Cutson J.J., Johnson L., Dietz K.R., Nicol C.J., Vinson C., Gonzalez F.J., and Reitman M.L. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278 (2003) 34268-34276
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34268-34276
-
-
Gavrilova, O.1
Haluzik, M.2
Matsusue, K.3
Cutson, J.J.4
Johnson, L.5
Dietz, K.R.6
Nicol, C.J.7
Vinson, C.8
Gonzalez, F.J.9
Reitman, M.L.10
-
20
-
-
0033695790
-
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
-
Memon R.A., Tecott L.H., Nonogaki K., Beigneux A., Moser A.H., Grunfeld C., and Feingold K.R. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141 (2000) 4021-4031
-
(2000)
Endocrinology
, vol.141
, pp. 4021-4031
-
-
Memon, R.A.1
Tecott, L.H.2
Nonogaki, K.3
Beigneux, A.4
Moser, A.H.5
Grunfeld, C.6
Feingold, K.R.7
-
21
-
-
0034743328
-
Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
-
Bedoucha M., Atzpodien E., and Boelsterli U.A. Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J. Hepatol. 35 (2001) 17-23
-
(2001)
J. Hepatol.
, vol.35
, pp. 17-23
-
-
Bedoucha, M.1
Atzpodien, E.2
Boelsterli, U.A.3
-
23
-
-
33845984572
-
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
-
Zhang Y.L., Hernandez-Ono A., Siri P., Weisberg S., Conlon D., Graham M.J., Crooke R.M., Huang L.S., and Ginsberg H.N. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J. Biol. Chem. 281 (2006) 37603-37615
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 37603-37615
-
-
Zhang, Y.L.1
Hernandez-Ono, A.2
Siri, P.3
Weisberg, S.4
Conlon, D.5
Graham, M.J.6
Crooke, R.M.7
Huang, L.S.8
Ginsberg, H.N.9
-
24
-
-
33644766913
-
PPARdelta regulates glucose metabolism and insulin sensitivity
-
Lee C.H., Olson P., Hevener A., Mehl I., Chong L.W., Olefsky J.M., Gonzalez F.J., Ham J., Kang H., Peters J.M., and Evans R.M. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc. Natl. Acad. Sci. USA 103 (2006) 3444-3449
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 3444-3449
-
-
Lee, C.H.1
Olson, P.2
Hevener, A.3
Mehl, I.4
Chong, L.W.5
Olefsky, J.M.6
Gonzalez, F.J.7
Ham, J.8
Kang, H.9
Peters, J.M.10
Evans, R.M.11
-
25
-
-
10744228031
-
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice
-
Matsuzaka T., Shimano H., Yahagi N., Amemiya-Kudo M., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Tomita S., Sekiya M., Hasty A., Nakagawa Y., Sone H., Toyoshima H., Ishibashi S., Osuga J., and Yamada N. Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. Diabetes 53 (2004) 560-569
-
(2004)
Diabetes
, vol.53
, pp. 560-569
-
-
Matsuzaka, T.1
Shimano, H.2
Yahagi, N.3
Amemiya-Kudo, M.4
Okazaki, H.5
Tamura, Y.6
Iizuka, Y.7
Ohashi, K.8
Tomita, S.9
Sekiya, M.10
Hasty, A.11
Nakagawa, Y.12
Sone, H.13
Toyoshima, H.14
Ishibashi, S.15
Osuga, J.16
Yamada, N.17
-
26
-
-
0037067570
-
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
-
Cohen P., Miyazaki M., Socci N.D., Hagge-Greenberg A., Liedtke W., Soukas A.A., Sharma R., Hudgins L.C., Ntambi J.M., and Friedman J.M. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297 (2002) 240-243
-
(2002)
Science
, vol.297
, pp. 240-243
-
-
Cohen, P.1
Miyazaki, M.2
Socci, N.D.3
Hagge-Greenberg, A.4
Liedtke, W.5
Soukas, A.A.6
Sharma, R.7
Hudgins, L.C.8
Ntambi, J.M.9
Friedman, J.M.10
-
27
-
-
33747034520
-
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
-
Biddinger S.B., Miyazaki M., Boucher J., Ntambi J.M., and Kahn C.R. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55 (2006) 2032-2041
-
(2006)
Diabetes
, vol.55
, pp. 2032-2041
-
-
Biddinger, S.B.1
Miyazaki, M.2
Boucher, J.3
Ntambi, J.M.4
Kahn, C.R.5
-
28
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., and Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94 (1997) 8878-8883
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-West, J.3
Fidahusein, N.4
Denton, D.A.5
Friedman, J.M.6
-
29
-
-
2542465882
-
Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin
-
da Silva A.A., Kuo J.J., and Hall J.E. Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin. Hypertension 43 (2004) 1312-1317
-
(2004)
Hypertension
, vol.43
, pp. 1312-1317
-
-
da Silva, A.A.1
Kuo, J.J.2
Hall, J.E.3
-
30
-
-
33745986945
-
Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin
-
Tallam L.S., da Silva A.A., and Hall J.E. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 48 (2006) 58-64
-
(2006)
Hypertension
, vol.48
, pp. 58-64
-
-
Tallam, L.S.1
da Silva, A.A.2
Hall, J.E.3
|