Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 8999-9008

  Álvarez, Concepción ^a   Álvarez, Raquel ^a   Corchete, Purificación ^a   Pérez Melero, Concepción ^a   Peláez, Rafael ^a   Medarde, Manuel ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Analogues; Antimitotic; Combretastatins; Cytotoxic; Docking; Naphthalene; Phenstatins; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; COLCHICINE; HYDRAZONE DERIVATIVE; NAPHTHYLPHENSTATIN DERIVATIVE; OXIME DERIVATIVE; PHENSTATIN; TUBULIN; TUBULIN MODULATOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANTINEOPLASTIC AGENTS; BENZALDEHYDES; BINDING SITES; CELL LINE, TUMOR; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HT29 CELLS; HUMANS; HYDRAZONES; INHIBITORY CONCENTRATION 50; LIGANDS; NAPHTHALENES; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 52949096485     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.040     Document Type: Article

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