New naphthylcombretastatins. Modifications on the ethylene bridge

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2097-2107

  Sánchez Maya, Ana B ^a   Pérez Melero, Concepción ^a   Salvador, Nélida ^b   Peláez, Rafael ^a   Caballero, Esther ^a   Medarde, Manuel ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b Instituto Biomar SA   (Spain)

Author keywords

Combretastatin analogues; Cytotoxicity; Heterocycle bridged; Naphthalene; Tubulin polymerization inhibition

Indexed keywords

1 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL) 1,2 ETHANEDIONE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTH 2 YL)PYRAZINE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTH 2 YL)PYRIDO[2,3 B]PYRAZINE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTH 2 YL)QUINOXALINE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTH 2 YL)QUINOXALINE 6 CARBOXYLIC ACID; 2 HYDROXY 2 (3,4,5 TRIMETHOXYPHENYL) 1 (NAPHTH 2 YL)ETHANONE; 2 METHYL 5 (3,4,5 TRIMETHOXYPHENYL) 4 (NAPHTH 2 YL)OXAZOLE; 2 TERT BUTYLDIMETHYLSILYLOXY 2 (3,4,5 TRIMETHOXYPHENYL) 1 (NAPHTH 2 YL)ETHANONE; 2 TERT BUTYLDIMETHYLSILYLOXY 2 (NAPHTH 2 YL)ACETONITRILE; 3 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL)PYRIDO[2,3 B]PYRAZINE; 3 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL)QUINOXALINE 6 CARBOXYLIC ACID; 3 DIMETHYLAMINO 1 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL)PROPENONE; 3 DIMETHYLAMINO 2 (3,4,5 TRIMETHOXYPHENYL) 1 (NAPHTH 2 YL)PROPENONE; 3 [5 METHOXY 3 (NAPHTH 2 YL) 2 (3,4,5 TRIMETHOXYPHENYL) 1H INDOL 1 YL] 1 DIMETHYLAMINOPROPAN 2 OL; 4 (3,4,5 TRIMETHOXYPHENYL) 5 (NAPHTH 2 YL) 1H PYRAZOLE; 4 (3,4,5 TRIMETHOXYPHENYL) 5 (NAPHTH 2 YL)ISOXAZOLE; 4 (3,4,5 TRIMETHOXYPHENYL) 5 (NAPHTH 2 YL)PYRIMIDINE; 5 (3,4,5 TRIMETHOXYPHENYL) 4 (NAPHTH 2 YL) 1H PYRAZOLE; 5 (3,4,5 TRIMETHOXYPHENYL) 4 (NAPHTH 2 YL)ISOXAZOLE; 5 (3,4,5 TRIMETHOXYPHENYL) 4 (NAPHTH 2 YL)PYRIMIDINE; 5 METHOXY 2 (3,4,5 TRIMETHOXYPHENYL) 3 (NAPHTH 2 YL) 1H INDOLE; 5 METHOXY 2 (NAPHTH 2 YL) 3 (3,4,5 TRIMETHOXYPHENYL) 1 (OXIRAN 2 YLMETHYL) 1H INDOLE; 5 METHOXY 3 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL) 1 METHYL 1H INDOLE; 5 METHOXY 3 (3,4,5 TRIMETHOXYPHENYL) 2 (NAPHTH 2 YL) 1H INDOLE; 5 METHOXY 3 (NAPHTH 2 YL) 2 (3,4,5 TRIMETHOXYPHENYL) 1 (OXIRAN 2 YLMETHYL) 1H INDOLE; COMBRETASTATIN A4; ETHYLENE DERIVATIVE; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MICROTUBULE ASSEMBLY;

EID: 13844311800     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.012     Document Type: Article

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