Overview of toxicological aspects of polybrominated diphenyl ethers: A flame-retardant additive in several consumer products

Environmental Research

Volumn 108, Issue 2, 2008, Pages 158-167

  Talsness, Chris E ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Neurobehavior; Plastic; Polybrominated diphenyl ethers (PBDEs); Polychlorinated biphenyls (PCBs); Reproduction; Thyroid hormones

Indexed keywords

ENDOCRINE DISRUPTOR; FLAME RETARDANT; LUBRICATING AGENT; PLASTIC; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; THYROID HORMONE;

BEHAVIORAL RESPONSE; BREASTFEEDING; COGNITION; ENDOCRINE DISRUPTOR; EPIDEMIOLOGY; GROWTH RESPONSE; HOMEOSTASIS; HORMONE; METABOLISM; PBDE; PCB; PLASTIC; POLLUTION EFFECT; POLLUTION EXPOSURE; PUBLIC HEALTH; REPRODUCTIVE HEALTH; RODENT; SEXUAL DIMORPHISM; TOXICOLOGY;

ARTICLE; BREAST MILK; CELL METABOLISM; CHEMICAL STRUCTURE; GENITAL SYSTEM; HALF LIFE TIME; NEUROTOXICITY; PERINATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN FUNCTION; TOXICOLOGY;

ANIMALS; CONSUMER PRODUCT SAFETY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; ETHERS; FLAME RETARDANTS; GOVERNMENT REGULATION; HUMANS; POLYBROMINATED BIPHENYLS;

RODENTIA;

EID: 52949096164     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2008.08.008     Document Type: Article

References (127)

1. Ahn M.Y., Filley T.R., Jafvert C.T., Nies L., Hua I., and Bezares-Cruz J. Photodegradation of decabromodiphenyl ether adsorbed onto clay minerals, metal oxides and sediment. Environ. Sci. Technol. 40 (2006) 215-220
2. Alaee M., Arias P., Sjödin A., and Bergman A. An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environ. Int. 29 (2003) 683-689
3. Alm H., Scholz B., Fischer C., Kultima K., Viberg H., Eriksson P., Dencker L., and Stigson M. Proteomic evaluation of neonatal exposure to 2,2′,4,4′,5-pentabromodiphenyl ether. Environ. Health Perspect. 114 (2006) 254-259
4. Alm H., Kultima K., Scholz B., Nilsson A., Andrén P.E., Fex-Svenningsen A., Dencker L., and Stigson M. Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex. Neurotoxicology 29 (2008) 628-637
5. Baldridge M.G., Stahl R.L., Gerstenberger S.L., Tripoli V., and Hutz R.J. Modulation of ovarian follicle maturation in long-evans rats exposed to polychlorinated biphenyls (PCBs) in utero and lactationally. Reprod. Toxicol. 17 (2003) 567-573
6. Bi X., Thomas G.O., Jones K.C., Qu W., Sheng G., Martin F.L., and Fu J. Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in South China. Environ. Sci. Technol. 41 (2007) 5647-5653
7. Bocio A., Llobet J.M., Domingo J.L., Corbella J., Teixido A., and Casas C. Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet. J. Agric. Food Chem. 51 (2003) 3191-3195
8. Boon J.P., Lewis W.E., Tjoen-A-Choy M.R., Allchin C.R., Lasw R.J., De Boer J., Ten Hall Tjabbes C.C., and Zegers B.N. Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food web. Environ. Sci. Technol. 36 (2002) 4025-4032
9. Bull K., Basu N., Zhang S., Martin J.W., Bursian S., Martin P., and Chan L.H. Dietary and in utero exposure of a pentabrominated diphenyl ether mixture did not affect cholinergic parameters in the cerebral cortex of ranch mink (Mustela vison). Toxicol. Sci. 96 (2007) 115-122
10. Cantón R.F., Sanderson J.T., Letcher R.J., Bergmann A., and van den Berg M. Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocorticol carcinoma cells. Toxicol. Sci. 88 (2005) 447-455
11. Ceccatelli R., Faass O., Schlumpf M., and Lichtensteiger W. Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE-99 and PCB. Toxicology 220 (2006) 104-116
12. Chan W.Y., and Ng T.B. Effect of hypothyroidism induced by propylthiouracil and thiourea on male and female reproductive systems of neonatal mice. J. Exp. Zool. 273 (1995) 160-169
13. Chao H.R., Wang S.L., Lee W.J., Wang Y.F., and Päpke O. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ. Int. 33 (2007) 239-245
14. Chen G., and Bunce N.J. Polybrominated diphenyl ethers as Ah receptor agonists and antagonists. Toxicol. Sci. 76 (2003) 310-320
15. Chen G., Konstantinov A.D., Chittim B.G., Joyce E.M., Bols N.C., and Bunce N.J. Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway. Environ. Sci. Technol. 35 (2001) 3749-3756
16. Chen Y.C., Guo Y.L., and Hsu C.C. Cognitive development of children prenatally exposed to polychlorinated biphenyls (Yu-Cheng children) and their siblings. J. Formos. Med. Assoc. 91 (1992) 704-707
17. Chevrier J., Eskenazi B., Bradman A., Fenster L., and Barr D.B. Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California. Environ. Health Perspect. 115 (2007) 1490-1496
18. Christensen J.R., MacDuffee M., Macdonald R.W., Whiticar M., and Ross P.S. Persistent organic pollutants in British Columbia grizzly bears: consequence of divergent diets. Environ. Sci. Technol. 39 (2005) 6952-6960
19. Cooke P.S., Porcelli J., and Hess R.A. Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PTU): the critical period. Biol. Reprod. 46 (1992) 146-154
20. Costabeber I., and Emanuelli T. Influence of alimentary habits, age and occupation on polychlorinate biphenyl levels in adipose tissue. Food Chem. Toxicol. 41 (2003) 73-80
21. Dang V.H., Choi K.C., and Jeung E.B. Tetrabromodiphenyl ether (BDE 47) evokes estrogenicity and calbindin-D9k expression through an estrogen receptor-mediated pathway in the uterus of immature rats. Toxicol. Sci. Epub. (2007)
22. Darnerud P.O., Eriksen G.S., Jóhannesson T., Larsen P.B., and Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure and toxicology. Environ. Health Perspect. 109 (2001) 49-68
23. Darnerud P.O., Aune M., Larsson L., and Hallgren S. Plasma PBDE and thyroxine levels in rats exposed to Bromkal or BDE-47. Chemosphere (2007) 10.1016/j.chemosphere.2006.05.133
24. Dijkstra G., de Rooij D.G., de Jong F.H., and van den Hurk R. Effect of hypothyroidism on ovarian follicular development, granulosa cell proliferation and peripheral hormone levels in the prepubertal rat. Eur. J. Endocrinol. 134 (1996) 649-654
25. Dufault C., Poles G., and Driscoll L.L. Brief postnatal PBDE exposure alters learning and the cholinergic modulation of attention in rats. Toxicol. Sci. 88 (2005) 172-180
26. Ellis-Hutchings R.G., Cherr G.N., Hanna L.A., and Keen C.L. Polybrominated diphenyl ether induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. Toxicol. Appl. Pharmacol. 215 (2006) 135-145
27. Eriksson J., Green N., Marsh G., and Bergman A. Photochemical decomposition of 15 polybrominated diphenyl ether congeners in methanol/water. Environ. Sci. Technol. 38 (2004) 3119-3125
28. Eriksson P., Jakobsson E., and Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?. Environ. Health Perspect. 109 (2001) 903-908
29. Eriksson P., Viberg H., Jakobsson E., Örn U., and Fredriksson A. A brominated flame retardant, 2, 2′,4,4′,5-pentabromodiphenyl ether: uptake retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol. Sci. 67 (2002) 98-103
30. Eriksson P., Fischer C., and Fredriksson A. Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects. Toxicol. Sci. 94 (2006) 302-309
31. Fowles J.R., Fairbrother A., Baecher-Steppan L., and Kerkvliet N.I. Immunologic and endocrine effects of the flame retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology 86 (1994) 49-61
32. Gerecke A.C., Hartmann P.C., Heeb N.V., Kohler H.P., Giger W., Schmid P., Zennegg M., and Kohler M. Anaerobic degradation of decabromodiphenyl ether. Environ. Sci. Technol. 39 (2005) 1078-1083
33. Guo Y.L., Lambert G.H., Hsu C.C., and Hsu M.M. Yucheng: health effects of prenatal exposure to polychlorinated biphenyls and dibenzofurans. Int. Arch. Occup. Environ. Health 77 3 (2004) 153-158
34. Gustafsson K., Björk M., Burreau S., and Gilek M. Bioaccumulation kinetics of brominated flame retardants (polybrominated diphenyl ethers) in blue mussels (Mytilus edulis). Environ. Toxciol. Chem. 18 (1999) 1218-1224
35. Guvenius D.M., Hassanzadeh P., Bergman A., and Noren K. Metabolites of polychlorinated biphenyls in human liver and adipose tissue. Environ. Toxicol. Chem. 21 (2002) 2264-2269
36. Guvenius D.M., Aronsson A., Ekman-Ordeberg G., Bergman A., and Norèn K. Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols and pentachlorophenol. Environ. Health Perspect. 111 (2003) 1235-1241
37. Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 13 (2003) 1021-1028
38. Hale R.C., La Guardia M.J., Harvey E.P., Gaylor M.O., Mainor T.M., and Duff W.H. Persistent pollutants in land-applied sludges. Nature 412 (2001) 140-141
39. Hale R.C., La Guardia M.J., Harvey E.P., Mainor T.M., Duff W.H., and Gaylor M.O. Polybrominated diphenyl ether flame retardants in Virginia freshwater fishes (USA). Environ. Sci. Technol. 35 (2001) 4585-4591
40. Hallgren S., and Darnerud P.O. Polybrominated diphenyl ethers (PBDEs), Polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 177 (2002) 227-243
41. Hallgren S., Sinjari T., Hakansson H., and Darnerud P.O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 75 (2001) 200-208
42. Hamers T., Kamstra J.H., Sonneveld E., Murk A.J., Kester M.H., Andersson P.L., Legler J., and Brouwer A. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicol. Sci. 92 (2006) 157-173
43. Hany J., Lilienthal H., Sarasin A., Roth-Härer A., Fastabend A., and Dunemann L. Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior. Toxicol. Appl. Pharmacol. 158 (1999) 231-243
44. Hardell L., van Bavel B., Lindström G., Eriksson M., and Carlberg M. In utero exposure to persistent organic pollutants in relation to testicular cancer risk. Int. J. Androl. 29 (2005) 228-234
45. Hassanin A., Breivik K., Meijer S.N., Steinnes E., Thomas G.O., and Jones K.C. PBDEs in European background soils: levels and factors controlling their distribution. Environ. Sci. Technol. 38 (2004) 738-745
46. Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 38 (2004) 945-956
47. Huwe J.K., and Smith D.J. Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure. Environ. Sci. Technol. 41 (2007) 2371-2377
48. Ingelido A.M., Ballard T., Dellatte E., di Domenico A., Ferri F., Fulgenti A.R., Herrmann T., Iacovella N., Miniero R., Päpke O., Porpora M.G., and De Felip E. Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in milk from Italian women living in Rome and Venice. Chemosphere (2007) ePrint
49. Jacobs M.N., Covaci A., and Schepens P. Investigation of selected persistent organic pollutants in farmed Atlantic salmon (Salmo salar), salmon aquaculture feed, and fish oil components of the feed. Environ. Sci. Technol. 36 (2002) 2797-2805
50. Jacobson J.L., and Jacobson S.W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N. Engl. J. Med. 335 (1996) 783-789
51. Johnson-Restrepo B., Kurunthachalam K., Rapaport D.P., and Rodan B.D. Polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue from New York. Environ. Sci. Technol. 39 (2005) 5177-5182
52. Jones-Otazo H.A., Clarke J.P., Miriam L.D., Archbold J.A., Ferguson G., Harner T., Richardson G.M., Ryan J.J., and Wilford B. Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs. Environ. Sci. Technol. 39 (2005) 5121-5130
53. Julander A., Karlsson M., Hagström K., Ohlson C.G., Engwall M., Bryngelsson I.-L., Westberg H., and van Bavel B. Polybrominated diphenyl ethers-plasma levels and thyroid status of workers at an electronic recycling facility. Int. Arch. Occup. Environ. Health 78 (2005) 584-592
54. Kierkegaard A., Asplund L., de Wit C.A., McLachlan M.S., Thomas G.O., Sweetman A.J., and Jones K.C. Fate of higher brominated PBDEs in lactating cows. Environ. Sci. Technol. 41 (2007) 417-423
55. 3H]arachadonic acid release in rat cerebellar granule neurons. Toxicol. Sci. 68 (2002) 451-457
56. Kodavanti P.R.S., and Ward T.R. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol. Sci. 85 (2005) 952-962
57. Kodavanti P.R.S., Ward T.R., Ludewig G., Robertson L.W., and Birnbaum L.S. Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships. Toxicol. Sci. 88 (2005) 181-192
58. Krishnamoorthy G., Venkataraman P., Arunkumar A., Vignesh R.C., Aruldhas M.M., and Arunakaran J. Ameliorative effect of vitamins (α-tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm. Reprod. Toxicol. 23 (2007) 239-245
59. Kuriyama S.N., and Chahoud I. In utero exposure to low-dose 2,3′,4,4′,5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Toxicology 202 (2004) 185-197
60. Kuriyama S.N., Talsness C.E., Grote K., and Chahoud I. Developmental exposure to low dose PBDE-99: effects on male fertility and neurobehavior in rat offspring. Environ. Health Perspect. 113 (2005) 149-154
61. Kuriyama S.N., Wanner A., Fidalgo-Neto A.A., Talsness C.E., Koerner W., and Chahoud I. Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels. Toxicology 242 (2007) 80-90
62. La Guardia M.J., Hale R.C., and Harvey E. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures. Environ. Sci. Technol. 40 (2006) 6247-6254
63. Lilienthal H., Hack A., Roth-Härer A., Wichert Grande S., and Talsness C.E. Effects of developmental exposure to 2,2′,4,4′,5-pentabromodipheyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ. Health Perspect. 114 (2006) 194-201
64. Lindberg P., Sellstrom U., Haggberg L., and de Wit C.A. Higher brominated diphenyl ethers and hexabromocyclododecane found in eggs of peregrine (falcons peregrinus) breeding in Sweden. Environ. Sci. Technol. 38 (2004) 93-96
65. Lorber M. Exposure of Americans to polybrominated diphenyl ethers. J. Expo. Sci. Environ. Epidemiol. 18 (2008) 2-19
66. Main K.M., Kiviranta H., Virtanen H.E., Sundqvist E., Tuomisto J.T., Tuomisto J., Vartiainen T., Skakkebaek N.E., and Toppari J. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environ. Health Perspect. 115 (2007) 1519-1526
67. Marsh G., Bergman A., Bladh L.-G., Gillner M., and Jakobsson E. Synthesis of p-hydroxybromodiphenyl ethers and binding to the thyroid hormone receptor. Organohalogen Compd. 37 (1998) 305-308
68. Matsuura N., Uchiyama T., Tada H., Nakamura Y., Kondo N., Morita M., and Fukushi M. Effects of dioxins and polychlorianted biphenyls (PCBs) on thyroid function in infants born in Japan-the second report from research on environmental health. Chemosphere 37 (2001) 1789-1793
69. McDonald T.A. Polybrominated diphenylether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs. Integr. Environ. Assess. Manage. 1 (2005) 343-354
70. Meerts I.A., van Zanden J.J., Luijks E.A., van Leeuwen-Bol I., Marsh G., Jakobsson E., Bergman A., and Brouwer A. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol. Sci. 56 1 (2000) 95-104
71. Meerts I.A.T.M., Letcher R.J., Hoving S., Marsh G., Bergman A., Lemmen J.G., van der Burg B., and Brouwer A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybromiated bisphenol A compounds. Environ. Health Perspect. 109 (2001) 399-407
72. Mercado-Feliciano M., and Bigsby R.M. The polybrominated diphenyl mixture DE-71 is mildly estrogenic. Environ. Health Perspect. 116 (2008) 605-611
73. Mörck A., Hakk H., Orn U., and Klasson Wehler E. Decabromodiphenyl ether in the rat: absroption, distribution, metabolism, and excretion. Drug Metab. Dispos. 31 (2003) 900-9007
74. Noren K., and Meironyté D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40 (2000) 1111-1123
75. Ohta S., Ishizuka D., Nishimura H., Nakao T., Aozasa O., Shimidzu Y., Ochiai F., Kida T., Nishi M., and Miyata H. Comparison of polybrominated diphenyl ethers in fish, vegetables and meats and levels in human milk of nursing women in Japan. Chemosphere 46 (2002) 689-696
76. Pacyniak E.K., Cheng X., Cunningham M., Crofton K., Klaassen C.D., and Guo G.L. The flame retardants, polybrominated diphenyl ethers (PBDE), are pregnane X receptor (PVR) activators. Toxicol. Sci. (2007) epub
77. Patandin S., Koopman-Esseboom C., de Ridder M.A., Weisglas-Kuperus N., and Sauer P.J. Effects of environmental exposure to polychlorinated biphenyls and dioxins on birth size and growth in Dutch children. Pediatr. Res. 44 (1998) 538-545
78. Patandin S., Lanting C.I., Mulder P.G., Boersma E.R., Sauer P.J., and Weisglas-Kuperus N. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J. Pediatr. 134 (1999) 33-41
79. Patel A.J., Hayashi M., and Hunt A. Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life. Brain Res. 422 (1987) 182-185
80. Peters A.K., Nijmeijer S., Gradin K., Backlund M., Bergman A., Poellinger L., Denison M.S., and Van den Berg M. Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathways. Toxicol. Sci. 92 (2006) 133-142
81. Petrik J., Drobna B., Pavuk M., Jursa S., Wimmerova S., and Chovancova J. Serum PCBs and organochlorine pesticides in Slovakia: age, gender, and residence as determinants of organochlorine concentrations. Chemosphere 65 (2006) 410-418
82. Qu W., Bi X., Sheng G., Lu S., Fu J., Yuan J., and Li L. Exposure to polybrominated diphenyl ethers among workers at an electronic waste dismantling region in Guangdong, China. Environ. Int. 33 (2007) 1029-1034
83. Rádiková Z., Tajtáková M., Kocan A., Trnovec T., Seböková E., Klimes I., and Langer P. Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia. Thyroid 18 (2008) 353-362
84. Reistad T., and Mariussen E. A commercial mixture of the brominated flame retardant pentabrominated diphenyl ether (DE-71) induces respiratory burst in human neutrophil granulocytes in vitro. Toxicol. Sci. 87 (2005) 57-65
85. Rice C.P., Chernyak S.M., Begnoche L., Quintal R., and Hickey J. Comparisons of PBDE composition and concentration in fish collected from the Detroit River, MI and Des Plaines River, IL. Chemosphere 49 (2002) 731-737
86. Richardson V.M., Staskal D.F., Ross D.G., Diliberto J.J., DeVito M.J., and Birnbaum L.S. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol. Appl. Pharmacol. 226 (2008) 244-250
87. Sanders J.M., Burka L.T., Smith C.S., Black W., James R., and Cunningham M.L. Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicol. Sci. 88 (2005) 127-133
88. Sandholm A., Emanuelsson B.M., and Wehler E.K. Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat. Xenobiotica 33 (2003) 1149-1158
89. Schecter A., Pavuk M., Päpke O., Ryan J.J., Birnbaum L., and Rosen R. Polybrominated diphenyl ethers (PBDEs) in US mothers' milk. Environ. Health Perspect. 111 (2003) 1723-1729
90. Schecter A., Papke O., Joseph J.E., and Tung K.C. Polybrominated diphenyl ethers (PBDEs) in US computers and domestic carpet vacuuming: possible sources of human exposure. J. Toxicol. Environ. Health A 68 (2005) 501-513
91. Schecter A., Päpke O., Harris R., Tung K.C., Musumba A., Olson J., and Birnbaum L. Polybrominated diphenyl ether (PBDE) levels in an expanded market basket survey of US food and estimated PBDE dietary intake by age and sex. Environ. Health Perspect. 114 (2006) 1515-1520
92. Schecter A., Johnson-Welch S., Tung K.C., Harris T.R., Papke O., and Rosen R. Polybrominated diphenyl ether (PBDE) levels in livers of US human fetuses and newborns. J. Toxicol. Environ. Health A 70 (2007) 1-6
93. Schell L.M., Gallo M.V., Denham M., Ravenscroft J., DeCaprio A.P., and Carpenter D.O. Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p′-DDE, and other toxicants in Akwesasne Mohawk Youth. Environ. Health Perspect. 116 (2008) 806-813
94. Schettler T. Toxic threats to neurologic development of children. Environ. Health Perspect. 109 Suppl. 6 (2001) 813-816
95. Schlummer M., Gruber L., Mäurer A., Wolz G., and van Eldik R. Characterization of polymer fractions from waste electrical and electronic equipment (WEEE) and implications for waste management. Chemosphere 67 (2007) 1866-1876
96. Schumacher M., Kiviranta H., Vartiainen T., and Domingo J.L. Concentrations of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in milk of women from Catalonia, Spain. Chemosphere (2007) ePrint
97. She J., Petreas M., Winkler J., Visita P., McKinney M., and Kopec D. PBDEs in the San Francisco Bay Area: measurements in harbour seal blubber and human breast adipose tissue. Chemosphere 46 (2002) 697-707
98. She J., Holden A., Sharp M., Tanner M., Williams-Derry C., and Hooper K. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from the Pacific Northwest. Chemosphere 12 (2007) 12 10.1016/j.chemosphere.2006.05.154
99. Soderstrom G., Sellstrom U., de Wit C.A., and Tysklind M. Photolytic debromination of decabromodiphenyl ether (BDE 209). Environ. Sci. Technol. 38 (2004) 127-132
100. Stapleton H.M., Dodder N.G., Offenberg J.H., Schantz M.M., and Wise S.A. Polybrominated diphenyl ethers in house dust and clothes dryer lint. Environ. Sci. Technol. 39 (2005) 925-931
101. Stoker T.E., Laws S.C., Crofton K.M., Hedge J.M., Ferrell J.M., and Cooper R.L. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicol. Sci. 78 (2004) 144-155
102. Stoker T.E., Cooper R.L., Lambright C.S., Wilson V.S., Furr J., and Gray L.E. In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol. Appl. Pharmacol. 207 (2005) 78-88
103. Takser L., Mergler D., Baldwin M., de Grosbois S., Smargiassi A., and Lafond J. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ. Health Perspect. 113 (2005) 1039-1044
104. Talsness C.E., Shakibaei M., Kuriyama S.N., Grande S.W., Sterner-Kock A., Schnitker P., de Souza C., Grote K., and Chahoud I. Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol. Lett. 157 (2005) 189-202
105. Talsness C.E., Kuriyama S.N., Sterner-Kock A., Schnitker P., Grande S.W., Shakibaei M., Andrade A., Grote K., and Chahoud I. In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring. Environ. Health Perspect. 116 (2008) 308-314
106. Tseng L.H., Lee C.W., Pan M.H., Tsai S.S., Li M.H., Chen J.R., Lay J.J., and Hsu P.C. Postnatal exposure of the male mouse to 2,2′,3,3′,4,4′,6,6′-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology 224 (2006) 33-43
107. Ulbrich B., and Stahlmann R. Developmental toxicity of polychlorinated biphenyls (PCBs): a systematic review of experimental data. Arch. Toxicol. 78 (2004) 252-268
108. Viberg H., Fredriksson A., and Eriksson P. Neonatal exposure to the brominated flame retardant 2,2′,4,4′,5-pentabromdiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol. Sci. 67 (2002) 104-107
109. Viberg H., Fredriksson A., Jakobsson E., Örn U., and Eriksson P. Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol. Sci. 76 (2003) 112-120
110. Viberg H., Fredriksson A., and Eriksson P. Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol. Appl. Pharmacol. 192 (2003) 95-106
111. Viberg H., Fredriksson A., and Eriksson P. Investigations of strain and/or gender differences in developmental neurotoxic effects of polybrominated diphenyl ethers in mice. Toxicol. Sci. 81 (2004) 344-353
112. Viberg H., Johansson N., Fredriksson A., Eriksson J., Marsh G., and Eriksson P. Neonatal exposure to higher brominated diphenyl ethers, heptabromo-(PBDE 183), octabromo-(PBDE 203) or nonabromodiphenyl ether (PBDE 206), impairs spontaneous behaviour, and learning and memory functions of adult mice. Toxicol. Sci. 92 (2006) 211-218
113. Viberg H., Fredriksson A., and Eriksson P. Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to 6 the brominated flame retardant, decabrominated diphenyl ether (PBDE 209). Neuro. Toxicol. 28 (2007) 136-142
114. Viberg H., Mundy W., and Eriksson P. Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis. Neuro. Toxicol. 29 (2008) 152-159
115. Vives I., Grimalt J.O., Lacorte S., Guillamon M., and Barcelo D. Polybromodiphenyl ether flame retardants in fish from lakes in European high mountains and Greenland. Environ. Sci. Technol. 38 (2004) 2338-2344
116. Voorspoels S., Covaci A., Lepom P., Escutenaire S., and Schepens P. Remarkable findings concerning PBDEs in the terrestrial top-predator red fox (Vulpes vulpes). Environ. Sci. Technol. 40 (2006) 2937-2943
117. Vreugdenhil H.J., Lanting C.I., Mulder P.G., Boersma E.R., and Weisglas-Kuperus N. Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age. J. Pediatr. 140 (2002) 48-56
118. Vreugdenhil H.J., Slijper F.M., Mulder P.G., and Weisglas-Kuperus N. Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age. Environ. Health Perspect. 110 (2002) A593-A598
119. Walkowiak J., Wiener J.A., Fastabend A., Heinzow B., Kramer U., Schmidt E., Steingruber H.J., Wundram S., and Winneke G. Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet 358 (2001) 1602-1607
120. Wang S.L., Su P.H., Jong S.B., Guo Y.L., Chou W.L., and Päpke O. In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. Environ. Health Perspect. 113 (2005) 1645-1650
121. Weiss B. Vulnerability of children and the developing brain to neurotoxic hazards. Environ. Health Perspect. 108 Suppl. 3 (2000) 375-381
122. WHO, 1996. Levels of PCBs, PCDDs and PCDFs in human milk. Environmental Health in Europe No. 3.
123. Wilford B.H., Shoeib M., Harner T., Zhu J., and Jones K.C. Polybrominated diphenyl ethers in indoor dust in Ottawa, Canada: implications for sources and exposure. Environ. Sci. Technol. 39 (2005) 7027-7035
124. Winneke G., Bucholski A., Heinzow B., Kramer U., Schmidt E., Walkowiak J., Wiener J.A., and Steingruber H.J. developmental neurotoxicity of polychlorinated biphenyls (PCBS): cognitive and psychomotor functions in 7-month old children. Toxicol. Lett. 102-103 (1998) 423-428
125. Zennegg M., Kohler M., Gerecke A.C., and Schmid P. Polybrominated diphenyl ethers in whitefish from Swiss lakes and farmed rainbow trout. Chemosphere 51 (2003) 545-553
126. Zhou T., Ross D.G., DeVito M.J., and Crofton K.M. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci. 61 (2001) 76-82
127. Zhou T., Taylor M.M., DeVito M.J., and Crofton K.M. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol. Sci. 66 (2002) 105-116