Metabolites of polychlorinated biphenyls in human liver and adipose tissue

Environmental Toxicology and Chemistry

Volumn 21, Issue 11, 2002, Pages 2264-2269

  Guvenius, Daiva Meironyté ^a   Hassanzadeh, Pari ^b   Bergman, Åke ^b   Norén, Koidu ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Adipose tissue; Liver; Metabolites; Polychlorinated biphenyls

Indexed keywords

CONCENTRATION (PROCESS); LIPIDS; METABOLITES; TISSUE;

HUMAN LIVER;

POLYCHLORINATED BIPHENYLS;

2,2',3,3',4,5' HEXACHLORO 4' BIPHENYLOL; 2,2',3,4,4',5' HEXACHLORO 3' BIPHENYLOL; MESYLIC ACID DERIVATIVE; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

PCB;

ADIPOSE TISSUE; ARTICLE; BIOACCUMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER; MASS SPECTROMETRY; METABOLITE; PRIORITY JOURNAL; STANDARD;

ADIPOSE TISSUE; AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, GAS; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; POLYCHLORINATED BIPHENYLS;

EID: 0036837882     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620211102     Document Type: Article

References (28)

1. Van den Berg KJ, Raaij JAGM, Bragt PC, Notten WRF. 1991. Interaction of halogenated industrial chemicals with transthyretin and effects in thyroid hormone level in vivo. Arch Toxicol 65:15-19.
2. Darnerud PO, Morse DC, Klasson-Wehler E, Brouwer A. 1996. Binding of a 3,3′,4,4′-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. Toxicology 106:105-114.
3. Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationship. Toxicol Appl Pharmacol 145:111-123.
4. Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. 1997. Examination of the estrogenicity of 2,4,6,2′,6′-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2′,6′-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2′,4′,6′-hexachlorobiphenyl (PCB 155). Environ Health Perspect 105:1238-1248.
5. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ, Klasson-Wehler E, Bergman Å, Visser TJ. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. Toxicol Ind Health 14:59-84.
6. Nagayama J, Okamura K, Iida T, Hirakawa H, Matsueda T, Tsuji H, Hasegawa M, Sato K, Ma H-Y, Yanagawa T, Igarashi H, Fukushige J, Watanabe T 1998. Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants. Chemosphere 37:1789-1793.
7. Kato Y, Haraguchi K, Shibahara T, Yumoto S, Masuda S, Kimura R. 1999. Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats. Toxicol Sci 48:51-54.
8. Meerts IATM. 2001. In vitro and in vivo interactions of organohalogens with the endocrine system - The role of metabolites and implications for human health. PhD thesis. Wageningen University, Wageningen, The Netherlands.
9. Letcher RJ, Klasson-Wehler E, Bergman Å. 2000. Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls. In Paasivirta J, ed, The Handbook of Environmental Chemistry: New Types of Persistent Halogenated Compounds, Vol 3-Part K. Springer-Verlag, Berlin, Germany, pp 315-359.
10. Jansson B, Jensen S, Olsson M, Renberg L, Sundström G, Vaz R. 1975. Identification by GC-MS of phenolic metabolites of PCB and p, p′-DDE isolated from Baltic guillemot and seal. Ambio 4: 93-97.
11. Jensen S, Jansson B. 1976. Anthropogenic substances in seal from the Baltic: Methyl sulfone metabolites of PCB and DDE. Ambio 5:257-260.
12. Bergman Å, Klasson-Wehler E, Kuroki H. 1994. Selective retention of hydroxylated PCB metabolites in blood. Environ Health Perspect 102:464-469.
13. Sandau CD, Ayotte P, Dewailly E, Duffe J, Norstrom RJ. 2000. Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian Inuit. Environ Health Perspect 108:611-616.
14. Hovander L, Malmberg T, Athanasiadou M, Athanassiadis I, Rahm S, Bergman A, Klasson Wehler E. 2002. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch Environ Contam Toxicol 42:105-117.
15. Fängström B, Athanasiadou M, Bergman Å, Grandjean P, Weihe P. 2000. Levels of PCBs and hydroxylated PCB metabolites in blood from pregnant Faroe island women. Proceedings, 20th International Symposium on Halogenated Environmental Organic Pollutants & POPs, Monterey, CA, USA, August 13-17, Vol 48, pp 21-24.
16. Weistrand C, Norén K, Nilsson A. 1997. Organochlorine compounds in blood from potentially exposed workers. PCB, PCN, PCDD/PCDF, HCB and methylsulphonyl metabolites of PCB. Environ Eniroi? Sci Pollut Res Int 4:2-9.
17. Norén K, Lundén Å, Pettersson E, Bergman Å. 1996. Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992. Environ Health Perspect 104:766-772.
18. Weistrand C, Norén K. 1997. Methylsulfonyl metabolites of PCB and DDE in human tissues. Environ Health Perspect 105:644-649.
19. Ballschmiter K, Bacher R, Mennel A, Fischer R, Riele U. 1992. The determination of chlorinated biphenyls, chlorinated dibenzodioxins and chlorinated dibenzofurans by GC/MS. J High Resolut Chromatogr 15:260-270.
20. Bergman Å, Klasson Wehler E, Kuroki H, Nilsson A. 1995. Synthesis and mass spectrometry of some methoxylated PCB. Chemosphere 30:1921-1938.
21. Bergman Å, Wachtmeister CA. 1978. Synthesis of methylthio- and methylsulfonyl-polychlorobiphenyls via nucleophilic aromatic substitution of certain types of polychlorobiphenyls. Chemosphere 12:949-956.
22. Haraguchi K, Kuroki H, Masuda Y. 1987. Synthesis and characterization of tissue-retainable methylsulfonyl polychlorinated biphenyl isomers. J Agric Food Chem 35:178-182.
23. Weistrand C, Norén K. 1998. Polychlorinated naphthalenes and other organochlorine contaminants in human adipose and liver tissue. J Toxicol Environ Health 53:293-311.
24. Bland M. 1996. An Introduction to Medical Statistics, 2nd ed. Oxford University Press, New York, NY, USA.
25. Leighty EG, Fentiman AF Jr, Thompson RM. 1980. Conjugation of fatty acids to DDT in the rat: Possible mechanism for retention. Toxicology 15:77-82.
26. Leighty EG, Fentiman AF Jr. 1982. Conjugation of pentachlorophenol to palmitic acid by liver microsomes. Bull Environ Contam Toxicol 28:329-333.
27. Ansari GAS, Britt SG, Reynolds ES. 1985. Isolation and characterization of palmitoylpentachlorophenol from human fat. Bull Environ Contain Toxicol 34:661-667.
28. Sjödin A, Tullsten AK, Klasson-Wehler E. 1998. Identification of the parent compounds to selectively retained hydroxylated PCB metabolites in rat blood plasma. Proceedings, 18th Symposium on Halogenated Environmental Organic Pollutants, Stockholm, Sweden, August 17-21, Vol 37, pp 365-368.