α4β1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation

American Journal of Physiology - Cell Physiology

Volumn 295, Issue 1, 2008, Pages

  Dikeman, Dustin A ^a   Rivera Rosado, Leslie A ^a   Horn, Troy A ^a   Alves, Christina S ^b   Konstantopoulos, Konstantinos ^b   Yang, Joy T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

Author keywords

Fibronectin; Lamellipodia; Shear stress

Indexed keywords

PAXILLIN; VERY LATE ACTIVATION ANTIGEN 4; FIBRONECTIN;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CHO CELL; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SHEAR FLOW; ANIMAL; ANISOTROPY; CELL ADHESION; CELL MOTION; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; SHEAR STRENGTH; SIGNAL TRANSDUCTION;

ANIMALS; ANISOTROPY; CELL ADHESION; CELL MOVEMENT; CHO CELLS; CRICETINAE; CRICETULUS; FIBRONECTINS; INTEGRIN ALPHA4BETA1; PAXILLIN; PHOSPHORYLATION; PROTEIN BINDING; RATS; SHEAR STRENGTH; SIGNAL TRANSDUCTION;

EID: 52749091191     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00169.2008     Document Type: Article

References (40)

1. Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 171: 1073-1084, 2005.
2. Arroyo AG, Yang JT, Rayburn H, Hynes RO. Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell 85: 997-1008, 1996.
3. Bloom L, Ingham KC, Hynes RO. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol Biol Cell 10: 1521-1536, 1999.
4. Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 133: 1403-1415, 1996.
5. Del Pozo MA, Kiosses WB, Alderson NB, Meller N, Hahn KM, Schwartz MA. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat Cell Biol 4: 232-239, 2002.
6. Diamond SL, Eskin SG, McIntire LV. Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science 243: 1483-1485, 1989.
7. Dickinson R, Tranquillo R. Optimal estimation of cell movement indices from the statistical analysis of cell tracking data. AIChE J 39: 1995-2010, 1993.
8. Euteneuer U, Schliwa M. Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules. Nature 310: 58-61, 1984.
9. 1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest 115: 1542-1551, 2005.
10. Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol 19: 173-206, 2003.
11. Ginsberg MH, Partridge A, Shattil SJ. Integrin regulation. Curr Opin Cell Biol 17: 509-516, 2005.
12. Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg MH. Spatial restriction of α4 integrin phosphorylation regulates lamellipodial stability and α4β1-dependent cell migration. J Cell Biol 162: 731-741, 2003.
13. Grazioli A, Alves CS, Konstantopoulos K, Yang JT. Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos. Dev Biol 293: 165-177, 2006.
14. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J Biol Chem 276: 40903-40909, 2001.
15. Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K. Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci USA 102: 14010-14015, 2005.
16. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S. Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res 39: 465-476, 2002.
17. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687, 2002.
18. Kil SH, Krull CE, Cann G, Clegg D, Bronner-Fraser M. The alpha4 subunit of integrin is important for neural crest cell migration. Dev Biol 202: 29-42, 1998.
19. Kiosses WB, Shattil SJ, Pampori N, Schwartz MA. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol 3: 316-320, 2001.
20. Kole TP, Tseng Y, Wirtz D. Intracellular microrheology as a tool for the measurement of the local mechanical properties of live cells. Methods Cell Biol 78: 45-64, 2004.
21. Konstantopoulos K, Kukreti S, McIntire LV. Biomechanics of cell interactions in shear fields. Adv Drug Delivery Res 33: 141-164, 1998.
22. Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 84: 359-369, 1996.
23. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci USA 99: 3546-3551, 2002.
24. Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature 402: 676-681, 1999.
25. Manevich E, Grabovsky V, Feigelson SW, Alon R. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. J Biol Chem 282: 25338-25348, 2007.
26. Nishiya N, Kiosses WB, Han J, Ginsberg MH. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol 7: 343-352, 2005.
27. Nishizaka T, Shi Q, Sheetz MP. Position-dependent linkages of fibronectin-integrin-cytoskeleton. Proc Natl Acad Sci USA 97: 692-697, 2000.
28. Pinco KA, He W, Yang JT. alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol Biol Cell 13: 3203-3217, 2002.
29. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112: 453-465, 2003.
30. Sengbusch JK, He W, Pinco KA, Yang JT. Dual functions of α4β1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol 157: 873-882, 2002.
31. Shyy JY, Chien S. Role of integrins in endothelial mechanosensing of shear stress. Circ Res 91: 769-775, 2002.
32. Tseng Y, Kole TP, Wirtz D. Micromechanical mapping of live cells by multiple-particle-tracking microrheology. Biophys J 83: 3162-3176, 2002.
33. Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 21: 6791-6800, 2002.
34. Vicente-Manzanares M, Zareno J, Whitmore L, Choi CK, Horwitz AF. Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J Cell Biol 176: 573-580, 2007.
35. Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells- over and over and over again. Nat Cell Biol 4: E97-E100, 2002.
36. Wojciak-Stothard B, Ridley AJ. Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol 161: 429-439, 2003.
37. Worthylake RA, Lemoine S, Watson JM, Burridge K. RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol 154: 147-160, 2001.
38. Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121: 549-560, 1995.
39. Zaidel-Bar R, Kam Z, Geiger B. Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow. J Cell Sci 118: 3997-4007, 2005.
40. Zwartz GJ, Chigaev A, Dwyer DC, Foutz TD, Edwards BS, Sklar LA. Real-time analysis of very late antigen-4 affinity modulation by shear. J Biol Chem 279: 38277-38286, 2004.